The main cause of mortality in great apes in zoological settings is cardiovascular disease (CVD), affecting all four taxa: chimpanzee (Pan troglodytes), bonobo (Pan paniscus), gorilla (Gorilla spp.) and orangutan (Pongo spp.). Myocardial fibrosis, the most typical histological characterisation of CVD in great apes, is non-specific, making it challenging to understand the aetiopathogenesis. A multifactorial origin of disease is assumed whereby many potential causative factors are directly or indirectly related to the diet, which in wild-living great apes mainly consists of high-fibre, low-carbohydrate and very low-sodium components. Diets of great apes housed in zoological settings are often different compared with the situation in the wild. Moreover, low circulating vitamin D levels have recently been recognised in great apes housed in more northern regions. Evaluation of current supplementation guidelines shows that, despite implementation of different dietary strategies, animals stay vitamin D insufficient. Therefore, recent hypotheses designate vitamin D deficiency as a potential underlying factor in the pathogenesis of myocardial fibrosis. The aim of this literature review is to: (i) examine important differences in nutritional factors between zoological and wild great ape populations; (ii) explain the potential detrimental effects of the highlighted dietary discrepancies on cardiovascular function in great apes; and (iii) elucidate specific nutrition-related pathophysiological mechanisms that may underlie the development of myocardial fibrosis. This information may contribute to understanding the aetiopathogenesis of myocardial fibrosis in great apes and pave the way for future clinical studies and a more preventive approach to great ape CVD management.

This paper surveys five human societal types – mobile foragers, horticulturalists, pre-state agriculturalists, state-based agriculturalists and liberal democracies – from the perspective of three core social problems faced by interacting individuals: coordination problems, social dilemmas and contest problems. We characterise the occurrence of these problems in the different societal types and enquire into the main force keeping societies together given the prevalence of these. To address this, we consider the social problems in light of the theory of repeated games, and delineate the role of intertemporal incentives in sustaining cooperative behaviour through the reciprocity principle. We analyse the population, economic and political structural features of the five societal types, and show that intertemporal incentives have been adapted to the changes in scope and scale of the core social problems as societies have grown in size. In all societies, reciprocity mechanisms appear to solve the social problems by enabling lifetime direct benefits to individuals for cooperation. Our analysis leads us to predict that as societies increase in complexity, they need more of the following four features to enable the scalability and adaptability of the reciprocity principle: nested grouping, decentralised enforcement and local information, centralised enforcement and coercive power, and formal rules.

The understanding of the genetic architecture of psychiatric disorders has made significant advances in the last decade and some scientific findings can now be translated into clinical practice. The rise of genetic testing and the awareness of patients and their families motivate psychiatrists to examine this approach. The COST Action EnGagE (CA17130) is promoting these developments in Europe. Whereas the findings of common variants are the domain of research, screening for rare variants at the genome-wide level is already applicable in clinical practice. It is now possible to return meaningful results to the individual to help him/her understanding the disease and the comorbidities, to guide treatment and to perform genetic counseling. In this presentation, we will give meaningful examples for psychiatric practice. For instance, around one-third of the patients diagnosed with autism spectrum disorder can benefit from a molecular diagnosis (fragile X syndrome, SHANK3 deletion…). Microdeletion or microduplication may explain a fraction of schizophrenic cases (e.g. del22q11). Identification of rare variants causing the disease may decrease the stigma and feeling of guilt often reported by patients and families. This could also help to detect and manage other comorbidities. It is expected that treatment guidelines and clinical trials would be developed in the near future for patients carrying a rare variant, opening the way to personalized psychiatry. Finally, this effort has a huge impact on the family, by enhancing genetic counseling in psychiatry. The rise of psychiatric genetics might align our field more closely with the other medical specialties.

The aim of this Research Reflection is to describe the basic rumen function of goats and its modification in response to environmental factors, as well as to discuss similarities and differences when compared to other ruminants. In so doing we shall reveal the adaptive capacity of goats to harsh environments. The basic rumen function in goats is similar to other species of ruminants, as stressed by the opportunity to apply the updates of feeding systems for ruminants to goats. The rumen epithelium acts as a protective barrier between the rumen and the host, but it can be damaged by toxic compounds or acidosis. The rumen also plays an important role in water balance, both for dehydration and rehydration. Recent studies show that the microbiota exhibits a high fractional stability due to functional redundancy and resilience, but this needs more investigation. The microbial community structure differs between goats and cows, which explains the difference in sensitivity to milk fat depression following intake of high lipid diets. Goats also differ from other ruminants by their enhanced ability to feed-sort, but as with cows they can suffer from acidosis. Nevertheless, goats can be considered to be very resistant to environmental factors such as water stress, salt stress or heat stress, and this is especially so in some endogenous breeds. They also are able to detoxify tannins, polyphenols and other secondary metabolites. Some new trials involving feeding behaviour, microbiota and omics or approaches by meta-analyses or modelling will improve our knowledge of rumen function in goats.

Mountain building in the Al-Hajar Mountains (NE Oman) occurred during two major shortening stages, related to the convergence between Africa–Arabia and Eurasia, separated by nearly 30 Ma of tectonic quiescence. Most of the shortening was accommodated during the Late Cretaceous, when northward subduction of the Neo-Tethys Ocean was followed by the ophiolites obduction on top of the former Mesozoic margin. This shortening event lasted until the latest Santonian – early Campanian. Maastrichtian to Eocene carbonates unconformably overlie the eroded nappes and seal the Cretaceous foredeep. These neo-autochthonous post-nappe sedimentary rocks were deformed, along with the underlying Cretaceous tectonic pile, during the second shortening event, itself including two main exhumation stages. In this study we combine remotely sensed structural data, seismic interpretation, field-based structural investigations and apatite (U–Th)/He (AHe) cooling ages to obtain new insights into the Cenozoic deformation stage. Seismic interpretation indicates the occurrence of a late Eocene flexural basin, later deformed by an Oligocene thrusting event, during which the post-nappe succession and the underlying Cretaceous nappes of the internal foredeep were uplifted. This stage was followed by folding of the post-nappe succession during the Miocene. AHe data from detrital siliciclastic deposits in the frontal area of the mountain chain provide cooling ages spanning from 17.3 to 42 Ma, consistent with available data for the structural culminations of Oman. Our work points out how renewal of flexural subsidence in the foredeep and uplift of the mountain belt were coeval processes, followed by layer-parallel shortening preceding final fold amplification.

In this paper, we study the power and limitations of computing effectively generic sequences using effectively random oracles. Previously, it was known that every 2-random sequence computes a 1-generic sequence (as shown by Kautz) and every 2-random sequence forms a minimal pair in the Turing degrees with every 2-generic sequence (as shown by Nies, Stephan, and Terwijn). We strengthen these results by showing that every Demuth random sequence computes a 1-generic sequence and that every Demuth random sequence forms a minimal pair with every pb-generic sequence (where pb-genericity is an effective notion of genericity that is strictly between 1-genericity and 2-genericity). Moreover, we prove that for every comeager ${\cal G} \subseteq {2^\omega }$, there is some weakly 2-random sequence X that computes some $Y \in {\cal G}$, a result that allows us to provide a fairly complete classification as to how various notions of effective randomness interact in the Turing degrees with various notions of effective genericity.

Distributed models and a good knowledge of the catchment studied are required to assess mitigation measures for nitrogen (N) pollution. A set of alternative scenarios (change of crop management practices and different strategies of landscape management, especially different sizes and distribution of set-aside areas) were simulated with a fully distributed model in a small agricultural catchment. The results show that current practices are close to complying with current regulations, which results in a limited effect of the implementation of best crop management practices. The location of set-aside zones is more important than their size in decreasing nitrate fluxes in stream water. The most efficient location is the lower parts of hillslopes, combining the dilution effect due to the decrease of N input per unit of land and the interception of nitrate transferred by sub-surface flows. The main process responsible for the interception effect is probably uptake by grassland and retention in soils since the denitrification load tends to decrease proportionally to N input and, for the scenarios considered, is lower in the interception scenarios than in the corresponding dilution zones.

In the mid-1990s, excellent results from the GRIP and GISP2 deep drilling projects in Greenland opened up funding for continued ice-coring efforts in Antarctica (EPICA) and Greenland (NorthGRIP). The Glaciology Group of the Niels Bohr Institute, University of Copenhagen, was assigned the task of providing drilling capability for these projects, as it had done for the GRIP project. The group decided to further simplify existing deep drill designs for better reliability and ease of handling. The drill design decided upon was successfully tested on Hans Tausen Ice Cap, Peary Land, Greenland, in 1995. The 5.0m long Hans Tausen (HT) drill was a prototype for the ~11m long EPICA and NorthGRIP versions of the drill which were mechanically identical to the HT drill except for a much longer core barrel and chips chamber. These drills could deliver up to 4m long ice cores after some design improvements had been introduced. The Berkner Island (Antarctica) drill is also an extended HT drill capable of drilling 2 m long cores. The success of the mechanical design of the HT drill is manifested by over 12 km of good-quality ice cores drilled by the HT drill and its derivatives since 1995.

The Deep Ice Sheet Coring (DISC) drill developed by Ice Coring and Drilling Services under contract with the US National Science Foundation is an electromechanical ice-drill system designed to take 122mm ice cores to depths of 4000 m. The new drill system was field-tested near Summit camp in central Greenland during the spring/summer of 2006. Testing was conducted to verify the performance of the DISC drill system and its individual components and to determine the modifications required prior to the system’s planned deployment for coring at the WAIS Divide site in Antarctica in the following year. The experiments, results and the drill crew’s experiences with the DISC drill during testing are described and discussed.

In response to the ‘oldest ice’ challenge initiated by the International Partnerships in Ice Core Sciences (IPICS), new rapid-access drilling technologies through glacier ice need to be developed. These will provide the information needed to qualify potential sites on the Antarctic ice sheet where the deepest section could include ice that is >1Ma old and still in good stratigraphic order. Identifying a suitable site will be a prerequisite for deploying a multi-year deep ice-core drilling operation to elucidate the cause and mechanisms of the mid-Pleistocene transition from 40 ka glacial–interglacial cycles to 100 ka cycles. As part of the ICE&LASERS/SUBGLACIOR projects, we have designed an innovative probe, SUBGLACIOR, with the aim of perforating the ice sheet down to the bedrock in a single season and continuously measuring in situ the isotopic composition of the melted water and the methane concentration in trapped gases. Here we present the general concept of the probe, as well as the various technological solutions that we have favored so far to reach this goal.

The Rosenberg Self-Esteem Scale is the most widely used instrument to assess self-esteem. In light of the absence of adaptations in Colombia, this study seeks to validate and adapt this scale in the Colombian population, and perform factorial equivalence with the Spanish version. A total of 1,139 seniors (633 Colombians and 506 Spaniards) were evaluated; the individuals answered the Rosenberg Self-Esteem Scale and sexual self-esteem scale. The average score of the items was similar to the questionnaire’s theoretical average, and standard deviations were close to one. The psychometric properties of the items are generally adequate with alphas of .83 and .86 and significant (CI = .95) and correlations with the sexual self-esteem scale ranging from .31 and .41. Factorial equivalence was confirmed by means of a structural equation model (CFI = .912 and RMSEA = .079), thus showing a strong level of invariance.

A set of infinite binary sequences ${\cal C} \subseteq 2$ℕ is negligible if there is no partial probabilistic algorithm that produces an element of this set with positive probability. The study of negligibility is of particular interest in the context of ${\rm{\Pi }}_1^0 $ classes. In this paper, we introduce the notion of depth for ${\rm{\Pi }}_1^0 $ classes, which is a stronger form of negligibility. Whereas a negligible ${\rm{\Pi }}_1^0 $ class ${\cal C}$ has the property that one cannot probabilistically compute a member of ${\cal C}$ with positive probability, a deep ${\rm{\Pi }}_1^0 $ class ${\cal C}$ has the property that one cannot probabilistically compute an initial segment of a member of ${\cal C}$ with high probability. That is, the probability of computing a length n initial segment of a deep ${\rm{\Pi }}_1^0 $ class converges to 0 effectively in n.

We prove a number of basic results about depth, negligibility, and a variant of negligibility that we call tt-negligibility. We provide a number of examples of deep ${\rm{\Pi }}_1^0 $ classes that occur naturally in computability theory and algorithmic randomness. We also study deep classes in the context of mass problems, examine the relationship between deep classes and certain lowness notions in algorithmic randomness, and establish a relationship between members of deep classes and the amount of mutual information with Chaitin’s Ω.