Prolonged grief disorder (PGD) is associated with impairments in cognitive functioning, but the neuropsychological correlates of early grief in older adults are poorly understood. This preliminary study cross-sectionally examined neuropsychological functioning in bereaved adults with high and low grief symptoms and a non-bereaved comparison sample and further explored the relationship between multidomain cognitive measures and grief severity. A total of ninety-three nondemented older adults (high grief: n = 44; low grief: n = 49) within 12 months post-bereavement and non-bereaved comparison participants (n = 43) completed neuropsychological battery including global and multiple domain-specific cognitive functioning. Linear regression models were used to analyze differences in multidomain cognitive measures between the groups and specifically examine the associations between cognitive performance and grief severity in the bereaved, after covariate adjustment, including depressive symptoms. Bereaved older adults with higher grief symptoms performed worse than those with lower symptoms and non-bereaved participants on executive functioning and attention and processing speed measures. In the bereaved, poorer executive functioning, attention and processing speed correlated with higher grief severity. Attention/processing speed–grief severity correlation was seen in those with time since loss ≤ 6 months, but not > 6 months. Intense early grief is characterised by poorer executive functioning, attention, and processing speed, resembling findings in PGD. The putative role of poorer cognitive functioning during early grief on the transition to integrated grief or the development of PGD remains to be elucidated.

Since the initial publication of A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals in 2008, the prevention of healthcare-associated infections (HAIs) has continued to be a national priority. Progress in healthcare epidemiology, infection prevention, antimicrobial stewardship, and implementation science research has led to improvements in our understanding of effective strategies for HAI prevention. Despite these advances, HAIs continue to affect ∼1 of every 31 hospitalized patients,1 leading to substantial morbidity, mortality, and excess healthcare expenditures,1 and persistent gaps remain between what is recommended and what is practiced.

The widespread impact of the coronavirus disease 2019 (COVID-19) pandemic on HAI outcomes2 in acute-care hospitals has further highlighted the essential role of infection prevention programs and the critical importance of prioritizing efforts that can be sustained even in the face of resource requirements from COVID-19 and future infectious diseases crises.3

The Compendium: 2022 Updates document provides acute-care hospitals with up-to-date, practical expert guidance to assist in prioritizing and implementing HAI prevention efforts. It is the product of a highly collaborative effort led by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Disease Society of America (IDSA), the Association for Professionals in Infection Control and Epidemiology (APIC), the American Hospital Association (AHA), and The Joint Commission, with major contributions from representatives of organizations and societies with content expertise, including the Centers for Disease Control and Prevention (CDC), the Pediatric Infectious Disease Society (PIDS), the Society for Critical Care Medicine (SCCM), the Society for Hospital Medicine (SHM), the Surgical Infection Society (SIS), and others.

The Hindu Raj region of northern Pakistan is situated between the Karakoram to the east and the Hindu Kush to the west. Both the Karakoram and the Hindu Kush are better studied and have well-documented, distinct geological histories. Investigation of the Hindu Raj region has been mainly limited to reconnaissance exploration and as such little is known about its tectonometamorphic history and whether that history is similar to its neighbouring areas. Analysis of new specimens collected along the Yasin Valley within the Hindu Raj region outline mid-to-Late Cretaceous pluton emplacement (ca. 105 and 95 Ma). Some of those plutonic rocks were metamorphosed to ∼750 ± 30 °C and 0.65 ± 0.05 GPa during the ca. 80–75 Ma docking of the Kohistan arc. A record of this collisional event is well-preserved to the west in the Hindu Kush and variably so to the east in the Hunza Karakoram. A subsequent, ca. 61 Ma, thermal event is partially preserved in Rb–Sr geochronology from the Hindu Raj, which overlaps with sillimanite-grade metamorphism in the Hunza portion of the Karakoram region to the east. Finally, apatite U–Pb and in situ Rb–Sr both record a late Eocene thermal/fluid event likely related to the India-Asia collision. These new data outline a complex geological history within the Hindu Raj, one that shares similarities with both adjacent regions. The information about the tectonometamorphic development of the Hindu Raj is important to gaining a detailed view of the geological characteristics of the southern Asian margin prior to the India-Asia collision.

Reliable spatially resolved compositional analysis through atom probe tomography requires an accurate placement of the detected ions within the three-dimensional reconstruction. Unfortunately, for heterogeneous systems, traditional reconstruction protocols are prone to position some ions incorrectly. This stems from the use of simplified projection laws which treat the emitter apex as a spherical cap, although the actual shape may be far more complex. For instance, sampled materials with compositional heterogeneities are known to develop local variations in curvature across the emitter due to their material phase specific evaporation fields. This work provides three pivotal precursors to improve the spatial accuracy of the reconstructed volume in such cases. First, we show scanning probe microscopy enables the determination of the local curvature of heterogeneous emitters, thus providing the essential information for a more advanced reconstruction considering the actual shape. Second, we demonstrate the cyclability between scanning probe characterization and atom probe analysis. This is a key ingredient of more advanced reconstruction protocols whereby the characterization of the emitter topography is executed at multiple stages of the atom probe analysis. Third, we show advances in the development of an electrostatically driven reconstruction protocol which are expected to enable reconstruction based on experimental tip shapes.

The Upper Mustang region of west-central Nepal contains exposures of metamorphosed Tethyan Sedimentary Sequence rocks that have been interpreted to reflect either contact metamorphism related to the nearby Mugu pluton or regional metamorphism associated with the North Himalayan domes. New monazite geochronology results show that the Mugu leucogranite crystallized at c. 21.3 Ma, while the dominant monazite age peaks from the surrounding garnet ± staurolite ± sillimanite schists range between c. 21.7 and 19.4 Ma, generally decreasing in age away from the pluton. Metamorphic temperature estimates based on Ti-in-biotite and garnet–biotite thermometry are highest in the specimens closest to the pluton (648 ± 24°C and 615 ± 25°C, respectively) and lowest in those furthest away (578 ± 24°C and 563 ± 25°C, respectively), while pressure estimates are all within uncertainty of one another, averaging 5.0 ± 0.5 kbar. These results are interpreted to be consistent with contact metamorphism of the rocks in proximity to the Mugu pluton, which was emplaced at c. 18 ± 2 km depth after local movement across the South Tibetan detachment system had ceased. While this new dataset helps to characterize the metamorphic rocks of the Tethyan Sedimentary Sequence and provides new constraints on the thickness of the upper crust, it also emphasizes the importance of careful integration of metamorphic conditions and inferred processes that may affect interpretation of currently proposed Himalayan models.

Some studies found that providing micronutrient powder (MNP) causes adverse health outcomes, but modifying factors are unknown. We aimed to investigate whether Fe status and inherited Hb disorders (IHbD) modify the impact of MNP on growth and diarrhoea among young Lao children. In a double-blind controlled trial, 1704 children of age 6–23 months were randomised to daily MNP (with 6 mg Fe plus fourteen micronutrients) or placebo for about 36 weeks. IHbD, and baseline and final Hb, Fe status and anthropometrics were assessed. Caregivers provided weekly morbidity reports. At enrolment, 55·6 % were anaemic; only 39·3 % had no sign of clinically significant IHbD. MNP had no overall impact on growth and longitudinal diarrhoea prevalence. Baseline Hb modified the effect of MNP on length-for-age (LAZ) (P for interaction = 0·082). Among children who were initially non-anaemic, the final mean LAZ in the MNP group was slightly lower (–1·93 (95 % CI –1·88, –1·97)) v. placebo (–1·88 (95 % CI –1·83, –1·92)), and the opposite occurred among initially anaemic children (final mean LAZ –1·90 (95 % CI –1·86, –1·94) in MNP v. –1·92 (95 % CI –1·88, –1·96) in placebo). IHbD modified the effect on diarrhoea prevalence (P = 0·095). Among children with IHbD, the MNP group had higher diarrhoea prevalence (1·37 (95 % CI 1·17, 1·59) v. 1·21 (95 % CI 1·04, 1·41)), while it was lower among children without IHbD who received MNP (1·15 (95 % CI 0·95, 1·39) v. 1·37 (95 % CI 1·13, 1·64)). In conclusion, there was a small adverse effect of MNP on growth among non-anaemic children and on diarrhoea prevalence among children with IHbD.