All canine hookworms are known to be zoonotic, causing infections ranging from transient skin irritations to prolonged ‘creeping eruptions’, eosinophilic enteritis and even patent intestinal infections. There is little information on canine hookworm species and their public health significance in sub-Saharan Africa. This study determined the prevalence and species of hookworms in dogs from different climatic zones of Kenya. Dog faecal samples were collected from the environment, and hookworm eggs were isolated by zinc chloride flotation and subjected to DNA extraction. Polymerase chain reaction (PCR) assays targeting the internal transcribed spacer (ITS) 1 and 2, 5.8S and 28S ribosomal RNA of Ancylostoma spp. and Uncinaria stenocephala were performed, and hookworm species were identified by PCR-restriction fragment length polymorphism (RFLP) or DNA sequencing. Hookworm eggs were detected by microscopy in 490/1621 (30.23%, 95% CI 28.01–32.54) faecal samples. Estimates of faecal prevalence were high in counties receiving higher rainfall (Narok 46.80%, Meru 44.88%) and low in those with a more arid climate (Isiolo 19.73%, Turkana 11.83%). In a subset of 70 faecal samples, Ancylostoma caninum (n = 59) was the most common species, followed by A. braziliense (n = 10) and A. cf. duodenale (n = 1). This study reports for the first time the detection of A. cf. duodenale in dog faeces and zoonotic hookworm species in Kenyan dogs. These findings emphasize the need for control measures such as enforcing laws for restraining stray dogs, regular deworming of dogs, and public health awareness programmes aimed at informing communities on outdoor use of footwear.

Missing outcome data plague many randomized experiments. Common solutions rely on ignorability assumptions that may not be credible in all applications. We propose a method for confronting missing outcome data that makes fairly weak assumptions but can still yield informative bounds on the average treatment effect. Our approach is based on a combination of the double sampling design and nonparametric worst-case bounds. We derive a worst-case bounds estimator under double sampling and provide analytic expressions for variance estimators and confidence intervals. We also propose a method for covariate adjustment using poststratification and a sensitivity analysis for nonignorable missingness. Finally, we illustrate the utility of our approach using Monte Carlo simulations and a placebo-controlled randomized field experiment on the effects of persuasion on social attitudes with survey-based outcome measures.

Regression discontinuity (RD) designs enable researchers to estimate causal effects using observational data. These causal effects are identified at the point of discontinuity that distinguishes those observations that do or do not receive the treatment. One challenge in applying RD in practice is that data may be sparse in the immediate vicinity of the discontinuity. Expanding the analysis to observations outside this immediate vicinity may improve the statistical precision with which treatment effects are estimated, but including more distant observations also increases the risk of bias. Model specification is another source of uncertainty; as the bandwidth around the cutoff point expands, linear approximations may break down, requiring more flexible functional forms. Using data from a large randomized experiment conducted by Gerber, Green, and Larimer (2008), this study attempts to recover an experimental benchmark using RD and assesses the uncertainty introduced by various aspects of model and bandwidth selection. More generally, we demonstrate how experimental benchmarks can be used to gauge and improve the reliability of RD analyses.

The zoonotic cestode Echinococcus ortleppi (Lopez-Neyra and Soler Planas, 1943) is mainly transmitted between dogs and cattle. It occurs worldwide but is only found sporadically in most regions, with the notable exception of parts of southern Africa and South America. Its epidemiology is little understood and the extent of intraspecific variability is unknown. We have analysed in the present study the genetic diversity among 178 E. ortleppi isolates from sub-Saharan Africa, Europe and South America using the complete mitochondrial cox1 (1608 bp) and nad1 (894 bp) DNA sequences. Genetic polymorphism within the loci revealed 15 cox1 and six nad1 haplotypes, respectively, and 20 haplotypes of the concatenated genes. Presence of most haplotypes was correlated to geographical regions, and only one haplotype had a wider spread in both eastern and southern Africa. Intraspecific microvariance was low in comparison with Echinococcus granulosus sensu stricto, despite the wide geographic range of examined isolates. In addition, the various sub-populations showed only subtle deviation from neutrality and were mostly genetically differentiated. This is the first insight into the population genetics of the enigmatic cattle adapted Echinococcus ortleppi. It, therefore, provides baseline data for biogeographical comparison among E. ortleppi endemic regions and for tracing its translocation paths.

Randomized experiments commonly compare subjects receiving a treatment to subjects receiving a placebo. An alternative design, frequently used in field experimentation, compares subjects assigned to an untreated baseline group to subjects assigned to a treatment group, adjusting statistically for the fact that some members of the treatment group may fail to receive the treatment. This article shows the potential advantages of a three-group design (baseline, placebo, and treatment). We present a maximum likelihood estimator of the treatment effect for this three-group design and illustrate its use with a field experiment that gauges the effect of prerecorded phone calls on voter turnout. The three-group design offers efficiency advantages over two-group designs while at the same time guarding against unanticipated placebo effects (which would undermine the placebo-treatment comparison) and unexpectedly low rates of compliance with the treatment assignment (which would undermine the baseline-treatment comparison).

Instruments for nuclear astrophysics collect photons using geometric optics, quantum optics or wave optics. Despite their disparate aperture systems, hard X- and soft gamma-ray telescopes have in common the way photons are detected, i.e. the non-dispersive spectroscopy performed in their detectors – gaz-filled counters, scintillators, and semiconductor detectors. The objective of the present short review is to focus on the status of these detectors in space-based gamma-ray instruments.

Very high energy gamma-ray astronomy is now bringing an invaluable contribution to the understanding of violent phenomena in the Universe, as well as the search for exotic physics such as indirect detection of dark matter or a test of Lorentz invariance violation. The current Imaging Arrays of Cherenkov Telescopes (IACT) show that this technique is mature. In Europe, the community is gathering around the Cherenkov Telescope Array consortium, to design and build the next generation ground-based array. It should reach an order of magnitude in sensitivity in a wide energy band, ranging from 10 GeV to more than 100 TeV. This goal can be achieved with an array of 50–100 telescopes of various sizes at various spacings. With about 2000 channels per camera, a specific effort has to be made to design front-end electronics with a lower cost and better performances. A gain in cost and performances can be obtained by maximising the integration of the front-end electronics in an ASIC. The amplifiers, analogue memories, digitization and first level buffering can be embedded in the same component. We present here the NECTAr project aiming at building a demonstrator element of a generic camera built around this component.

The fast development of nitrides has given the opportunity to investigate AlGaN as a material for ultraviolet detection. A camera based on such a material presents an extremely low dark current at room temperature. It can compete with technologies based on photocathodes, MCP intensifiers, back thinned CCD or hybrid CMOS focal plane arrays for low flux measurements. First, we will present results on focal plane array of 320 × 256 pixels with a pitch of 30 μm. The peak responsivity is tuned from 260 nm to 360 nm in different cameras. All these results are obtained in a standard SWIR supply chaine and with AlGaN Schottky diodes grown on sapphire. We will present here the first attempts to transfer the standard design Schottky photodiodes on from sapphire to silicon substrates. We will show the capability to remove the silicon substrate, to etch the window layer in order to extend the band width to lower wavelength and to maintain the AlGaN membrane integrity.

This paper concentrates on a first demonstrator, a 23 NbSi superconducting thermometer array, developed in the DCMB collaboration. Firstly, the NbSi thin film alloy is described then the 23 TES array topology is presented. After that, DC and noise cryogenic measurement is reported. The cryogenic readout chain is also presented and finally, the multiplexing scheme developed for the readout of the 23 pixels array is described.

X-ray microcalorimeter arrays are well suited to address key problems in high-energy astrophysics; this microcalorimeter uses thermometers based on technology IDT (Implanted Diffused Thermometer) implemented in silicon-on-insulator (SOI) wafers. This work presents our results on the test (measurements) of the thermometer prototype.

The aim of this paper is to give an overview of CMOS imaging detectors (principles and technologies) and an overview of CNES activities in this domain.

For a variety of scientific, space and defence applications, there is an increasing demand for long-wavelength infrared (LWIR) detector focal plane arrays and compact infrared instruments. In the first part, we present an overview of alternative detectors to standard mercury cadmium telluride photodiodes for LWIR detection, such as the HgCdTe avalanche photodiode, the quantum-well infrared photo-detectors, the superlattice detectors and the carbone nanotubes-based bolometers. In the second part, we focus on new concepts developed to meet the requirement of miniaturization of infrared instruments. Original IRFPA-based micro-optical assemblies have been achieved, demonstrating several optical functions such as imagery, spectral filtering, spectrometry and wavefront sensing.

VIHI: the Visible and Infrared Hyperspectral Imager is one of the three channels of the Simbio-Sys instrument for the BepiColombo mission to Mercury. Its scientific objective is to study the hermean surfaces composition by sensing the photon flux reflected off the planet. VIHI works in the range of 400 to 2000 nm with a spectral resolution around a few hundreds. The particularity of this channel is the use of a single detector matrix (264 × 264) for both visible and infrared wavelengths. Getting the visible part of the detector responsivity is achieved by thinning an infrared HgCdTe matrix because visible light is completely absorbed inside the substrate. The thinning process is well controlled since a long time and was used to increase number of thermal cycle of the hybrid devices. Recently, this process is able to remove completely the substrate and, thus, open the detector to the visible range. The detector is a custom design made by Raytheon Vision System in Goleta (USA). In this paper, we will describe the expected performances of the detector which is designed to work in the very harsh radiation environment of Mercury.