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Both transposition of the great arteries (TGA) previously submitted to a Senning/Mustard procedure and congenitally corrected TGA (cc-TGA) have the systemic circulation supported by the morphological right ventricle, thereby rendering these patients to heart failure events risk. The aim of this study was to evaluate cardiopulmonary exercise test parameters for stratifying the risk of heart failure events in TGA patients.
Retrospective evaluation of adult TGA patients with systemic circulation supported by the morphological right ventricle submitted to cardiopulmonary exercise test in a tertiary centre. Patients were followed up for at least 1 year for the primary endpoint of cardiac death or heart failure hospitalisation. Several cardiopulmonary exercise test parameters were analysed as potential predictors of the combined endpoint and their predictive power were compared (area under the curve).
Cardiopulmonary exercise test was performed in 44 TGA patients (8 cc-TGA), with a mean age of 35.1 ± 8.4 years. The primary endpoint was reached by 10 (22.7%) patients, with a mean follow-up of 36.7 ± 26.8 months. Heart rate at anaerobic threshold had the highest area under the curve value (0.864), followed by peak oxygen consumption (pVO2) (0.838). Heart rate at anaerobic threshold ≤95 bpm and pVO2 ≤20 ml/kg/min had a sensitivity of 87.5 and 80.0% and a specificity of 82.4 and 76.5%, respectively, for the primary outcome.
Heart rate at anaerobic threshold ≤95 bpm had the highest predictive power of all cardiopulmonary exercise test parameters analysed for heart failure events in TGA patients with systemic circulation supported by the morphological right ventricle.
Space Infrared Telescope for Cosmology and Astrophysics (SPICA), the cryogenic infrared space telescope recently pre-selected for a ‘Phase A’ concept study as one of the three remaining candidates for European Space Agency (ESA's) fifth medium class (M5) mission, is foreseen to include a far-infrared polarimetric imager [SPICA-POL, now called B-fields with BOlometers and Polarizers (B-BOP)], which would offer a unique opportunity to resolve major issues in our understanding of the nearby, cold magnetised Universe. This paper presents an overview of the main science drivers for B-BOP, including high dynamic range polarimetric imaging of the cold interstellar medium (ISM) in both our Milky Way and nearby galaxies. Thanks to a cooled telescope, B-BOP will deliver wide-field 100–350
m images of linearly polarised dust emission in Stokes Q and U with a resolution, signal-to-noise ratio, and both intensity and spatial dynamic ranges comparable to those achieved by Herschel images of the cold ISM in total intensity (Stokes I). The B-BOP 200
m images will also have a factor
30 higher resolution than Planck polarisation data. This will make B-BOP a unique tool for characterising the statistical properties of the magnetised ISM and probing the role of magnetic fields in the formation and evolution of the interstellar web of dusty molecular filaments giving birth to most stars in our Galaxy. B-BOP will also be a powerful instrument for studying the magnetism of nearby galaxies and testing Galactic dynamo models, constraining the physics of dust grain alignment, informing the problem of the interaction of cosmic rays with molecular clouds, tracing magnetic fields in the inner layers of protoplanetary disks, and monitoring accretion bursts in embedded protostars.
This is a copy of the slides presented at the meeting but not formally written up for the volume.
Recently, the telecommunication market experiences an explosion in the subscribers of emergent high-debit services which require bandwidth that exceeds the one provided by actual copper based access networks . To cope with these demands and keep competitive, great efforts have been done to develop access networks based on optical technology, such as passive all-optical networks due to their intrinsic low cost . Sol-gel processing is suitable for the development of organic-inorganic hybrid (OIH) materials for the production of functional integrated optic (IO) devices in a cost effective way. Urea cross-linked OIH show acceptable transparency, mechanical flexibility and thermal stability [3-6]. The control over the refractive index is achieved by zirconium (IV) n-propoxide (ZPO) doping stabilized with methacrylic acid (MA) [3-5]. The combination in a single material of urea cross-linked OIH and ZPO allowed the preparation of UV written low losses planar waveguides  and low rugosity diffraction grating [4,5]. It has been demonstrated that MA acts not only as ZPO stabilizer but impacts directly on the photopolimerization properties as it contains a photopolymerizable group making the OIH easily UV patterned without photoinitiator . Moreover, it also impacts on the OHIs local structure as it forms a complex with ZPO, that originate ordered clusters dispersed within the OIH host [4,5]. Besides the potential of this OIH as IO components, the hybrid hosts are room-temperature efficient white light emitters lacking metal activator ions, presenting quantum yields as higher as 20 % . In this work, a series of OIH, so called di-ureasils, formed of a siliceous skeleton to which oligopolyether chains of different lengths are covalently grafted by means of urea bridges and modified by ZPO and MA will be prepared and characterized by X-ray and small angle X-ray diffractions, Raman, infrared, atomic force and photoluminescence spectroscopies. The use of the proposed OIH in the development of IO functionalities such as optical filters will be evaluated based on waveguide numerical simulation methods (beam propagation method). Waveguides will be written and characterized using the OIH aforementioned. The recording of a Bragg grating in the waveguides allow the implementation of a wavelength discrimination device with applications on optical filtering. The relevant properties of the devices, such as spectral rejection and insertion losses will be characterized.  S-J Park et al. Journal of Lightwave Tech. 22, 2004.  D.J. Shin et al., Journal of Lightwave Tech. 23, 2005.  C. Molina et al., J. Mater. Chem. 15, 3937, 2005.  R.A. Sá Ferreira et al., Proceedings of the International Conference on Telecomunications, 2006.  P.S. André et al. Proceedings ICTON, 1, We.C1.6, 223, 2006.  a) L.D. Carlos et al., Adv. Func. Mater. 11, 111, 2001; b) J. Chem. Phys. B. 108, 14924, 2004. Siemens SA and FCT (POCTI/CTM/59075/2004) is gratefully acknowledged.
The Beck’s Petrel Pseudobulweria beckii is a ‘Critically Endangered’ seabird whose breeding sites remain unknown. Historic observations suggest the species’ distribution is concentrated in the Bismarck Archipelago and particularly southern New Ireland. Over the course of two research expeditions in 2016 and 2017 we used on-land and at-sea observations, local interviews and satellite telemetry to understand the distribution of the species, its at-sea movements and potential breeding locations. Land-based and at-sea observations indicated that the area of Silur Bay in southern New Ireland was a significant site for Beck’s Petrel with numbers of birds increasing near shore prior to dusk and birds observed in spotlights over land. A local population is estimated to be in the low thousands. In 2017 a single Beck’s was captured at sea, fitted with a satellite transmitter and tracked for eight months. This bird maintained a core distribution off the south-east coast of New Ireland and north of Bougainville for 122 days. During the tracking period, the bird was located over land at night seven times; predominantly over southern New Ireland, where the signal was also lost for extended periods suggesting occupancy of an underground burrow. In August the bird migrated 1,400 km to a core pelagic habitat north of West Papua before the signal was eventually lost. Our combination of land- and sea-based observations and analysis of behaviour from satellite tracking supports the conclusion that a breeding site for Beck’s Petrel lies in the inland mountains of southern New Ireland and most likely in the high-altitude zone (> 2000 m) of the Hans Meyer Range. Further investigations are required to determine the exact location of breeding colonies in the mountains of southern New Ireland and the importance of a potential west Papuan non-breeding pelagic habitat for the species.
This qualitative study explores the experiences of older adults participating in a creative visual arts program at a residential care facility in Victoria, British Columbia. A narrative inquiry approach was used to conduct face-to-face interviews with 10 residents and three program staff in addition to the systematic observations of program activities and an arts exhibit. The findings reveal the program fostered a sense of community among participants and enhanced their sense of self-worth as artists. A public art exhibition at a community centre underlined the value of residents’ artwork and gave meaning and purpose to their involvement in the program. Findings show the importance of arts programs in fostering creativity in later life and illustrate how people living in institutions can experience multiple dimensions of the self through artistic forms of expression. This study highlights the need to increase access to arts programs for individuals living in residential care.
Twenty one years ago, the discovery of the giant magnetocaloric effect (GMCE) at room temperature completely revolutionized the magnetocaloric materials field demonstrating the potential of magnetic refrigeration at room temperature and setting the beginning of a race for the best magnetocaloric material. Since then, hundreds of different bulk magnetic materials were studied in detail; however, only a small set of these exhibit GMCE. In the last ten years, the broad interest on these materials leads to the extension of their study to the micro- and nanoscale. In this review, we highlight the main motivations for exploring the size-reduction both from the technological and the purely scientific point of view and stress the general consequences on the magnetic and magnetocaloric properties. The emergence of different underlying mechanisms driving these effects will be identified with particular emphasis for the set of materials presenting GMCE.
Although food from grazed animals is increasingly sought by consumers because of perceived animal welfare advantages, grazing systems provide the farmer and the animal with unique challenges. The system is dependent almost daily on the climate for feed supply, with the importation of large amounts of feed from off farm, and associated labour and mechanisation costs, sometimes reducing economic viability. Furthermore, the cow may have to walk long distances and be able to harvest feed efficiently in a highly competitive environment because of the need for high levels of pasture utilisation. She must, also, be: (1) highly fertile, with a requirement for pregnancy within ~80 days post-calving; (2) ‘easy care’, because of the need for the management of large herds with limited labour; (3) able to walk long distances; and (4) robust to changes in feed supply and quality, so that short-term nutritional insults do not unduly influence her production and reproduction cycles. These are very different and are in addition to demands placed on cows in housed systems offered pre-made mixed rations. Furthermore, additional demands in environmental sustainability and animal welfare, in conjunction with the need for greater system-level biological efficiency (i.e. ‘sustainable intensification’), will add to the ‘robustness’ requirements of cows in the future. Increasingly, there is evidence that certain genotypes of cows perform better or worse in grazing systems, indicating a genotype×environment interaction. This has led to the development of tailored breeding objectives within countries for important heritable traits to maximise the profitability and sustainability of their production system. To date, these breeding objectives have focussed on the more easily measured traits and those of highest relative economic importance. In the future, there will be greater emphasis on more difficult to measure traits that are important to the quality of life of the animal in each production system and to reduce the system’s environmental footprint.
The objective of the current experiment was to determine the effects of increasing levels of palm kernel cake in a finishing diet on feed intake, digestibility, performance, ingestive behaviour and carcass traits in zebu bulls. Thirty-two Nellore bulls (420 ± 25.0 kg initial body weight [BW] and 24-months-old), were assigned randomly to individual pens with four treatments (0, 70, 140 and 210 g/kg of palm kernel cake by total dry matter [DM]) and eight replicates per treatment. The inclusion of palm kernel cake linearly decreased DM, crude protein and non-fibrous carbohydrate intake and increased ether extraction intake and digestibility. There was a linear decrease in final BW and hot carcass weight (HCW) associated with palm kernel cake inclusion in the bull diet. However, the gain : feed ratio was similar among the diets. Eating and rumination rates (g DM or neutral detergent fibre/h) were reduced, whereas the total chewing time and idling (min/day) were not affected by palm kernel cake inclusion. There were no effects of palm kernel cake inclusion on most quantitative carcass characteristics and qualitative carcass attributes (subcutaneous fat thickness, longissimus muscle area, colour, texture and marbling). The inclusion of palm kernel cake (up to 210 g/kg total DM) in beef cattle finishing diets decreased eating and rumination rates, thereby decreasing average daily gain and, consequently, final BW and HCW. However, qualitative carcass attributes were not affected by the use of palm kernel cake.
We examined the association between plasma antioxidant levels and markers of inflammation, including C-reactive protein (CRP) and fibrinogen (FG) in US adults. National Health and Nutrition Examination Survey participants examined between 2001 and 2002 were included, if data on CRP or FG levels. Serum vitamins A and E, two retinyl esters, and six carotenoids were measured using HPLC with photodiode array detection. Multivariable-adjusted linear regression analyses accounted for the survey design and sample weights. A total of 784 eligible participants were included; 47·5 % (n 372) were men. In multivariable linear regression models, serum α-carotene, trans-β-carotene, cis-β-carotene, β-cryptoxanthin, combined lutein/zeaxanthin, trans-lycopene, retinyl palmitate, α-tocopherol, retinol and 25-hydroxy vitamin D were negatively associated with serum CRP (P<0·001 for all comparisons). Serum α-carotene, trans-β-carotene, cis-β-carotene, combined lutein/zeaxanthin, trans-lycopene, α-tocopherol, retinol and 25-hydroxy vitamin D were negatively associated with serum FG levels (P<0·001 for all comparisons). In the same model, the risk of CVD, defined as CRP levels >3 mg/l, decreased with increasing levels of antioxidants (α-carotene, trans-β-carotene, cis-β-carotene, vitamins A and E). Furthermore, we found a moderate impact of adiposity on the link between antioxidants and CRP. Our results suggest that the lower the antioxidants levels, the higher the inflammatory burden, based on CRP and FG levels. Adiposity moderately affects this association. Furthermore, an inverse relationship between CVD risk and antioxidant levels was observed. This finding suggests that reduced levels of vitamins with antioxidant properties may predispose to increased CVD risk.
Rumen microbiome profiling uses 16S rRNA (18S rRNA, internal transcribed spacer) gene sequencing, a method that usually sequences a small portion of a single gene and is often biased and varies between different laboratories. Functional information can be inferred from this data, but only for those that are closely related to known annotated species, and even then may not truly reflect the function performed within the environment being studied. Genome sequencing of isolates and metagenome-assembled genomes has now reached a stage where representation of the majority of rumen bacterial genera are covered, but this still only represents a portion of rumen microbial species. The creation of a microbial genome (bins) database with associated functional annotations will provide a consistent reference to allow mapping of RNA-Seq reads for functional gene analysis from within the rumen microbiome. The integration of multiple omic analytics is linking functional gene activity, metabolic pathways and rumen metabolites with the responsible microbiota, supporting our biological understanding of the rumen system. The application of these techniques has advanced our understanding of the major microbial populations and functional pathways that are used in relation to lower methane emissions, higher feed efficiencies and responses to different feeding regimes. Continued and more precise use of these tools will lead to a detailed and comprehensive understanding of compositional and functional capacity and design of techniques for the directed intervention and manipulation of the rumen microbiota towards a desired state.
It may be possible for dairy farms to improve profitability and reduce environmental impacts by selecting for higher feed efficiency and lower methane (CH4) emission traits. It remains to be clarified how CH4 emission and feed efficiency traits are related to each other, which will require direct and accurate measurements of both of these traits in large numbers of animals under the conditions in which they are expected to perform. The ranking of animals for feed efficiency and CH4 emission traits can differ depending upon the type and duration of measurement used, the trait definitions and calculations used, the period in lactation examined and the production system, as well as interactions among these factors. Because the correlation values obtained between feed efficiency and CH4 emission data are likely to be biased when either or both are expressed as ratios, therefore researchers would be well advised to maintain weighted components of the ratios in the selection index. Nutrition studies indicate that selecting low emitting animals may result in reduced efficiency of cell wall digestion, that is NDF, a key ruminant characteristic in human food production. Moreover, many interacting biological factors that are not measured directly, including digestion rate, passage rate, the rumen microbiome and rumen fermentation, may influence feed efficiency and CH4 emission. Elucidating these mechanisms may improve dairy farmers ability to select for feed efficiency and reduced CH4 emission.
Herbivores are found in a variety of ecosystems all over the world. Permanent pastures and meadows cover about 25% of global land. We currently count one domesticated herbivore for two people in the world and the number is growing. Production systems and products are highly diverse. This high diversity is the result of thousands of years of natural selection and human-controlled breeding, as well as migration and trade. Because of the high diversity of domestic herbivore genetic resources, herders have been able to live in regions where no alternative for income generation exists. Meat and milk from domestic herbivores provide 16% and 8% of the global protein and kilocalorie consumption, respectively. They also provide a variety of essential micronutrients but can contribute to overweight and obesity when consumed in excess. Domestic herbivores also make significant contribution to food security through the production of manure, draught power and transport and the generation of income at household and national level. They have a key role to play in women’s empowerment and gender equality, both in rural and urban areas.
Demand for meat and milk is increasing because of population growth, rising incomes and urbanisation. This trend is expected to continue, especially in Latin America, South Asia and China. The sustainable development of domestic herbivore production needs to address the feed/food and the efficiency of herbivores in turning forages into protein. It also needs to address the contribution of herbivores to greenhouse gas emissions, especially of ruminants through enteric fermentation, and their mitigation potential, including through carbon sequestration. Animal genetic resources have a key role to play in mitigating and adapting to climate change. The role of ruminants in the circular bioeconomy needs to be enhanced, promoting the use of by-products and waste as livestock feed and the recycling of manure for energy and nutrients. Finally, the role of domestic herbivores in providing secure livelihoods and economic opportunities for millions of smallholder farmers and pastoralists needs to be enhanced. The sustainable development of the sector therefore requires adequate policies, and there are already a variety of mechanisms available, including regulations, cross-compliance systems, payments for environmental services and research and development. Priority areas for policy makers should be aligned with the global framework of the Sustainable Development Goals and include: (i) food security and nutrition, (ii) economic development and livelihoods, (iii) animal and human health and finally, (iv) environment, climate and natural resources.
On-farm nutrition and management interventions to reduce enteric CH4 (eCH4) emission, the most abundant greenhouse gas from cattle, may also affect volatile solids and N excretion. The objective was to jointly quantify eCH4 emissions, digestible volatile solids (dVS) excretion and N excretion from dairy cattle, based on dietary variables and animal characteristics, and to evaluate relationships between these emissions and excreta. Univariate and Bayesian multivariate mixed-effects models fitted to 520 individual North American dairy cow records indicated dry matter (DM) intake and dietary ADF and CP to be the main predictors for production of eCH4 emissions and dVS and N excreta (g/day). Yields (g/kg DM intake) of eCH4 emissions and dVS and N excreta were best predicted by dietary ADF, dietary CP, milk yield and milk fat content. Intensities (g/kg fat- and protein-corrected milk) of eCH4, dVS and N excreta were best predicted by dietary ADF, dietary CP, days in milk and BW. A K-fold cross-validation indicated that eCH4 and urinary N variables had larger root mean square prediction error (RMSPE; % of observed mean) than dVS, fecal N and total N production (on average 24.3% and 26.5% v. 16.7%, 15.5% and 16.2%, respectively), whereas intensity variables had larger RMSPE than production and yields (29.4%, 14.7% and 14.6%, respectively). Univariate and multivariate equations performed relatively similar (18.8% v. 19.3% RMSPE). Mutual correlations indicated a trade-off for eCH4v. dVS yield. The multivariate model indicated a trade-off between eCH4 and dVS v. total N production, yield and intensity induced by dietary CP content.
Growth in demand for foods with potentially beneficial effects on consumer health has motivated increased interest in developing strategies for improving the nutritional quality of ruminant-derived products. Manipulation of the rumen environment offers the opportunity to modify the lipid composition of milk and meat by changing the availability of fatty acids (FA) for mammary and intramuscular lipid uptake. Dietary supplementation with marine lipids, plant secondary compounds and direct-fed microbials has shown promising results. In this review, we have compiled information about their effects on the concentration of putative desirable FA (e.g. c9t11-CLA and vaccenic, oleic, linoleic and linolenic acids) in ruminal digesta, milk and intramuscular fat. Marine lipids rich in very long-chain n-3 polyunsaturated fatty acids (PUFA) efficiently inhibit the last step of C18 FA biohydrogenation (BH) in the bovine, ovine and caprine, increasing the outflow of t11-18:1 from the rumen and improving the concentration of c9t11-CLA in the final products, but increments in t10-18:1 are also often found due to shifts toward alternative BH pathways. Direct-fed microbials appear to favourably modify rumen lipid metabolism but information is still very limited, whereas a wide variety of plant secondary compounds, including tannins, polyphenol oxidase, essential oils, oxygenated FA and saponins, has been examined with varying success. For example, the effectiveness of tannins and essential oils is as yet controversial, with some studies showing no effects and others a positive impact on inhibiting the first step of BH of PUFA or, less commonly, the final step. Further investigation is required to unravel the causes of inconsistent results, which may be due to the diversity in active components, ruminant species, dosage, basal diet composition and time on treatments. Likewise, research must continue to address ways to mitigate negative side-effects of some supplements on animal performance (particularly, milk fat depression) and product quality (e.g. altered oxidative stability and shelf-life).
Epidemiological studies in humans and animal models (including ruminants and horses) have highlighted the critical role of nutrition on developmental programming. Indeed, it has been demonstrated that the nutritional environment during the periconceptional period and foetal development can altered the postnatal performance of the resultant offspring. This nutritional programming can be exerted by maternal and paternal lineages and can affect offspring beyond the F1 generation. Alterations in epigenetic mechanisms have been proposed as the causative link behind the programming trajectories observed in the offspring. Although a clear cause–effect relationship between epigenetic modifications during early development and later offspring phenotype has not been demonstrated in livestock species, strong associations have been reported for some epigenetic marks (e.g. messenger RNA) that are worth exploring as possible predictors of future offspring phenotype. In this review, we shortly describe the main epigenetic mechanisms studied so far in mammals (i.e. mainly in the mouse) thought to be associated with developmental programming, and discuss the few studies available in mammalian herbivores (e.g. cattle) showing the effect of nutrition on epigenetic marks and the associated phenotype. Clearly, there is a need to develop research on nutritional strategies capable of modulating the epigenetic machinery with positive influence on the phenotype of livestock herbivores. This type of research is needed to alleviate the challenges currently faced by the livestock industry (e.g. impaired fertility of high-yielding dairy cows). This in turn will have a positive influence on animal welfare and productivity of livestock enterprises.
The present review will present the recent published results and discuss the main effects of nutrients, mainly fatty acids, on the expression of genes involved in lipid metabolism. In this sense, the review focuses in two phases: prenatal life and finishing phase, showing how nutrients can modulate gene expression affecting marbling and fatty acid profile in meat from ruminants. Adiposity in ruminants starts to be affected by nutrients during prenatal life when maternal nutrition affects the differentiation and proliferation of adipose cells enhancing the marbling potential. Therefore, several fetal programming studies were carried out in the last two decades in order to better understand how nutrients affect long-term expression of genes involved in adipogenesis and lipogenesis. In addition, during the finishing phase, marbling becomes largely dependent on starch digestion and glucose metabolism, being important to create alternatives to increase these metabolic processes, and modulates gene expression. Different lipid sources and their fatty acids may also influence the expression of genes responsible to encode enzymes involved in fat tissue deposition, influencing meat quality. In conclusion, the knowledge shows that gene expression is a metabolic factor affecting marbling and fatty acid profile in ruminant meat and diets and their nutrients have direct effect on how these genes are expressed.
The role of herbivorous livestock in supporting the sustainability of the farming systems in which they are found is complex and sometimes conflicting. In Sub-Saharan Africa (SSA), the integration of livestock into farming systems is important for sustainable agriculture as the recycling of nutrients for crop production through returns of animal manure is a central element of the dominant mixed crop-livestock systems. Sustainable agriculture has been widely advocated as the main practical pathway to address the challenge of meeting the food needs of the rapidly growing population in SSA while safeguarding the needs of future generations. The objective of this paper is to review the state of knowledge of the role of herbivores in sustainable intensification of key farming systems in SSA. The pathways to sustainable agriculture in SSA include intensification of production and livelihood diversification. Sustainable agricultural practices in SSA have focused on intensification practices which aim to increase the output : input ratio through increasing use of inputs, introduction of new inputs or use of existing inputs in a new way. Intensification of livestock production can occur through increased and improved fodder availability, genetic production gains, improved crop residue use and better nutrient recycling of manure. Livestock deliver many ‘goods’ in smallholder farming systems in SSA including improving food and nutrition security, increased recycling of organic matter and nutrients and the associated soil fertility amendments, adding value to crop residues by turning them into nutrient-rich foods, income generation and animal traction. Narratives on livestock ‘bads’ or negative environmental consequences have been largely shaped by the production conditions in the Global North but livestock production in SSA is a different story. In SSA, livestock are an integral component of mixed farming systems and they play key roles in supporting the livelihoods of much of the rural population. None-the-less, the environmental consequences of livestock production on the continent cannot be ignored. To enhance agricultural sustainability in SSA, the challenge is to optimize livestock’s role in the farming systems by maximizing livestock ‘goods’ while minimizing the ‘bads’. This can be through better integration of livestock into the farming systems, efficient nutrient management systems, and provision of necessary policy and institutional support.
Salmonella prevalence in UK pigs is amongst the highest in Europe, highlighting the need to investigate pig farms which have managed to maintain a low Salmonella seroprevalence. A total of 19 pig farms that had a consistently low (<10%) seroprevalence over 4 years (named Platinum farms) were compared against 38 randomly selected Control farms, chosen to match the same distribution of production types and geographical distribution of the Platinum farms. Each farm was visited and floor faeces and environmental samples were collected. It was shown that Control farms had a significantly higher median percentage of pooled faecal samples positive for Salmonella compared with the Platinum farms (12.1% and 0.4% for pooled faecal samples, respectively) and were more likely to have serovars of public health importance detected (S. Typhimurium/ monophasic variants or S. Enteritidis). Considering the comprehensive on-farm sampling, the identification of farms negative for Salmonella, along with the identification of those that had maintained low prevalence over a long period is important. The risk factor analyses identified pelleted feed, feed deliveries crossing farm perimeter and regular antibiotic use as associated with being a Control farm. Performance data indicated that Platinum farms were performing better for slaughter live weight than Controls. Limited assessments of available pig movement records suggested that the source of pigs was not key to Platinum status, but further study would be needed to confirm this finding. These results emphasise that maintaining very low prevalence on UK farms is achievable.