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We develop rapid chemical vapor sensors and micro gas chromatography (μGC) analyzers based on the optofluidic ring resonator (OFRR). An OFRR is a micro-sized thin-walled glass capillary; the circular cross-section of the capillary acts as an optical ring resonator while the whispering gallery modes or circulating waveguide modes (WGMs) supported by the ring resonator interact with the vapor samples passing through the capillary. The OFRR interior surface is coated with a vapor-sensitive polymer. The analyte and polymer interaction causes the polymer refractive index (RI) and the thickness to change, which is detected as a WGM spectral shift. Owing to the excellent fluidics, the OFRR vapor sensor exhibits sub-second detection and recovery time with a flow rate of 1 mL/min. On-column separation and detection in the OFRR based μGC system is also demonstrated, showing efficient separation of vapor mixtures and presenting highly reproducible retention time for the individual analyte. Compared to the conventional GC system, the OFRR μGC has the advantage of small size, rapid response, and high selectivity over a short length of column.
Neospora caninum is a commonly diagnosed cause of reproductive losses in farmed ruminants worldwide. This study examined 495 and 308 samples (brain, heart and placenta) which were collected from 455 and 119 aborted cattle and sheep fetuses, respectively. DNA was extracted and a nested Neospora ITS1 PCR was performed on all samples. The results showed that for bovine fetuses 79/449 brain [17.6% (14.2–21.4)], 7/25 heart [28.0% (12.1–49.4)] and 5/21 placenta [23.8% (8.2–47.2)] were PCR positive for the presence of Neospora DNA. Overall 82/455 [18.0% (14.6–21.7)] of the bovine fetuses tested positive for the presence of N. caninum DNA in at least one sample. None (0/308) of the ovine fetal samples tested positive for the presence of Neospora DNA in any of the tissues tested. The results show that N. caninum was associated with fetal losses in cattle (distributed across South-West Scotland), compared to sheep in the same geographical areas where no parasite DNA was found. Neospora is well distributed amongst cattle in South-West Scotland and is the potential cause of serious economic losses to the Scottish cattle farming community; however, it does not appear to be a problem amongst the Scottish sheep flocks.
Background: Brain tumors present unique challenges to patient and family quality of life (QOL). Cognitive dysfunction is common and functionally limiting, with no established treatments. These studies evaluate feasibility and preliminary efficacy of behavioral interventions developed for neuro-oncology patients. Study 1: A randomized controlled trial (N=25 primary brain tumor patients) compared an adapted version of Goal Management Training (GMT, a neuroscience-based integration of mindfulness and strategy training) and a newly-designed supportive psychoeducational intervention (Brain Health Program, BHP) to standard of care. Each intervention comprised 8 individual sessions and at-home practice between sessions. GMT patients’ executive functions improved immediately (p=.077, d=1.13), with maintenance at 4-month follow-up (p=.046, d=1.09). Both intervention groups reported improvements in everyday cognitive functioning immediately (p=.049; d’s GMT=0.43, BHP=0.79) and at follow-up (p=.001; d’s GMT=0.22, BHP=1.01). BHP patients also reported improved mood (p’s=.026 & .012, d’s=0.61 & 0.62). Study 2: Following a needs assessment about cognitive concerns and QOL in brain metastases patients (N=109) and caregivers (N=31), we developed a novel, brief (3 sessions + homework) Cognitive Support Program to provide education and strategy-training in key areas of concern: executive functions, memory, and communication. Options include caregiver co-training, and in-person or web-based delivery. Preliminary data from a pilot trial in progress demonstrate objective and subjective improvements. Conclusions: Cognitive rehabilitation may be a feasible and effective option for primary or metastatic brain tumor patients, addressing a need that is largely unmet in standard cancer care. Further development and larger trials appear warranted, with capacity for remote delivery recommended.
Atypical Teratoid Rhabdoid Tumors (AT/RTs) often affect children under the age of 3 and are the most common malignant CNS tumors in children younger than 6 months. It is very rare to see these tumors in patients older than 6 years of age. We discuss the case of a 14 year old male with AT/RT of the right insula. He had a prior diagnosis of Dysembryoplastic Neuroectodermal Tumor (DNET) at the age of 10, after two years of intermittent headaches, nausea, and seizures, which was treated with conformal radiation and chemotherapy for a year. Following the diagnosis of AT/RT, he underwent radiotherapy, multiple lines of chemotherapy, and two additional debulking surgeries of the left temporal lobe due to continuing progression. He was then treated with Alisertib (an Aurora-A kinase inhibitor) with good response on sequential MRIs after the first three cycles. He progressed after nine cycles of Alisertib and required further debulking surgery. Six years after his AT/RT diagnosis (and 10 years after his DNET diagnosis), the patient expired at the age of 20 due to ongoing progression. To our knowledge, this is only the second reported case of Alisertib use in a non-pediatric AT/RT case. We also performed a literature review of all reported cases of AT/RT in adults between the years 2000 – 2017 and discuss treatment options, patient demographics, and survival.
Background: Bevacizumab has been used in recurrent glioblastoma (rGBM) since 2010 in Canada. Given its cost, potential toxicities, and unclear efficacy, further studies are required to better define suitable candidates for therapy. Methods: A single-center retrospective review of patients started on bevacizumab for rGBM from 2012 to 2015 was performed. Patient demographics, tumor characteristics, treatment regimen, and dates of clinical progression and death were collected. Overall survival (OS) and progression-free survival (PFS) were used as clinical outcomes and estimates. Radiological response was assessed using modified Response Assessment in Neuro-Oncology criteria. Results: A total of 80 patients were included. There were 67 reported deaths, and the median OS was 9.2 months (95% confidence interval [CI95%]=7.0-10.1 months), with a 12-month OS of 31% (CI95%=21.9-43.5%). Some 79 patients were included for analysis of clinical progression, among whom 61 had documented clinical progression. The median clinical PFS was 4.6 months (CI95%=3.8-6.4 months), and the 6-month clinical PFS was 39% (CI95%=29.0-52.9%). Addition of chemotherapy did not improve clinical outcomes. A total of 68 patients were included for radiological progression analysis, with 58 radiological progressions. The median radiological PFS was 5.8 months (CI95%=4.2-6.7 months), and the 6-month radiological PFS was 46% (CI95%=35.6-60.0%). Conclusions: This is the first reported Canadian experience with bevacizumab for rGBM. Our clinical outcomes are consistent with published data from multicenter phase II and III trials on bevacizumab in rGBM. More research is required to determine which subtype(s) of patients with rGBM could benefit from bevacizumab upon recurrence.
Drug use during pregnancy and lactation remain underdeveloped areas of clinical pharmacology and drug research. Pregnancy risk factors together with an increased incidence of chronic diseases and a rise in the average maternal age predict medication use will continue to rise during gestation. Common exposure categories include over-the-counter (OTC) medication, psychiatric agents, gastrointestinal medications, herbals, vitamins, antibiotics, and topical products. Only a few medications have been tested specifically for safety and efficacy during human gestation. Profound physiologic changes occur during both normal and pathologic pregnancy that may dramatically alter drug clearance, efficacy, and safety. Under such circumstances, the danger of a drug to mothers, their fetuses, and nursing infants cannot be determined with any confidence until it has been widely used. It is important that women with medical disorders such as diabetes, hypertension, epilepsy, and inflammatory bowel disease continue necessary therapy while pregnant. Unfortunately, many physicians stop or delay medically important agents precisely because of the lack of information.
The deep ice-sheet coring (DISC) drill consists of four major mechanical drilling subsystems and four subsystems supporting on-surface activities. The mechanical drilling subsystems are a drill sonde, a drill cable, a tower and a winch. The drill sonde is the down-hole portion of the drill system and consists of six distinct sections: (1) the cutter head, (2) the core barrel, (3) the screen section, (4) the motor/pump section, (5) the instrument section and (6) the upper sonde, which includes anti-torques and drill cable terminations. The drill cable not only provides the means of supporting the drill sonde in the borehole, but also provides conduits for electrical power and data transmission. The tower tilts to allow the drill sonde to be serviced in the horizontal position without removing it from the tower. The winch provides a means of quickly raising the sonde from the borehole and providing the fine control necessary for coring operations.
The Deep Ice Sheet Coring (DISC) drill, developed by Ice Coring and Drilling Services (ICDS) under contract with the US National Science Foundation, is an electromechanical drill designed to take 122 mm diameter ice cores to depths of 4000 m. The conceptual design of the DISC drill was developed in 2002/03 based on science requirements written by K. Taylor and the United States ice-coring community and on engineering performance objectives. Detailed design of the drill began in June 2003. Special attention was paid to building safety into the design and operation of the drill system. The drill was designed and manufactured by a team of engineers and technicians from the University of Wisconsin–Madison and various subcontractors with assistance from the science community, the European ice-drilling community and polar logistical support organizations. ICDS successfully tested the drill in Greenland in 2006 and will continue its development to meet the science objectives of the West Antarctic Ice Sheet Divide Ice Core Project.
The Deep Ice Sheet Coring (DISC) drill developed by Ice Coring and Drilling Services under contract with the US National Science Foundation is an electromechanical ice-drill system designed to take 122mm ice cores to depths of 4000 m. The new drill system was field-tested near Summit camp in central Greenland during the spring/summer of 2006. Testing was conducted to verify the performance of the DISC drill system and its individual components and to determine the modifications required prior to the system’s planned deployment for coring at the WAIS Divide site in Antarctica in the following year. The experiments, results and the drill crew’s experiences with the DISC drill during testing are described and discussed.
The Neogene was a time of transition both in the development of the present vegetation and the palynological study of it. The vegetation cover changed from one dominated by rainforest, which is traditionally regarded as ‘Tertiary’, to one in which rainforest became very reduced in extent. The nature of this change has been difficult to document due to an increasingly arid landscape with a concomitant reduction in suitable pollen preservation sites. The difficulty has been compounded by a relative lack of palynological study on the period. Stratigraphic palynologists have focussed on the earlier part of the Tertiary and there is no formal or well dated biostratigraphy, for much of the period under consideration, that is applicable to Australian terrestrial environments. Palynologists concerned with vegetation reconstruction have largely restricted their attention to the later part of the Quaternary period and have had variable success when venturing back into the Tertiary, as the vegetation then was frequently very different from that of today. Consequently, the database from which we piece together this critical period in Australia's vegetation history is very fragmentary and of varying quality.
In keeping with the problematic documentation of vegetation, there are difficulties in defining the period itself. There is general agreement on its beginning - the Miocene began about 25 million years (Ma) ago, although this does not necessarily hold any palynostratigraphic or biogeographical significance - but there are different views on the best location of the end of the period, i.e. the Pliocene/Pleistocene boundary. Conventionally this boundary is placed at the top of the Olduvai palaeomagnetic event dated to 1.6 Ma (Berggren et aL, 1985) but there is increasing pressure to reposition this close to the Gauss/Matuyama palaeomagnetic reversal boundary, around 2.4 Ma, as this reflects more closely the beginning of the substantial cooling and climatic fluctuations that characterise the Pleistocene period (Zagwin, 1985; Kukla, 1989).
Major factors influencing the whole of Australia during the Neogene include global climatic changes and the northward movement of the continent. The build up of ice on Antarctica, partly a result of the northward movement of Australia, which allowed the development of a circum-Antarctic ocean current, caused a steepening of the temperature gradient from equator to pole and development of the present atmospheric circulation pattern (Kemp, 1978).
Background: Radiotherapy with procarbazine, lomustine, and vincristine improves overall survival (OS) in patients with 1p19q co-deleted anaplastic oligodendroglioma/anaplastic oligoastrocytoma. Methods: This retrospective analysis investigated outcomes in patients with 1p19q co-deleted/partially deleted oligodendroglioma, oligoastrocytoma, anaplastic oligodendroglioma, or anaplastic oligoastrocytoma. OS and progression-free survival (PFS) were analyzed using the Kaplan-Meier method and prognostic factors using the Cox proportional hazard model. Results: A total of 106 patients (between December 1997 and December 2013) were included. Median age was 40 years (19-66), 58 were male (55%), Eastern Cooperative Oncology Group performance status was 0 in 80 patients (75%). 1p19q status was co-deleted in 66 (62%), incompletely co-deleted in 27 (25%), and 1p or 19q loss alone in four (4%) and nine (8%) patients, respectively. Isocitrate dehydrogenase-1 R132H mutation was found in 67 of 85 patients with sufficient material. Upfront treatment was given in 72 (68%) patients and temozolomide alone in 52 (49%). Median time to radiotherapy in 47 patients (44%) was 34.7 months and 41.2 months in 9 patients with co-deleted/incompletely co-deleted anaplastic oligodendroglioma/anaplastic oligoastrocytoma who received upfront temozolomide alone. Median OS was not reached and 5-year OS was 91% for all groups (median follow-up, 5.1 years). On multivariable analysis for all patients, receipt of therapy upfront versus none (p=0.04), PS 1 versus 0 (p<0.001) and 1p19q co-deletion/incomplete deletion versus 1p or 19q loss alone (p=0.005) were prognostic for PFS. Isocitrate dehydrogenase-1 status was not prognostic for PFS. Conclusions: With similar survival patterns in low-grade/anaplastic gliomas, molecular characteristics may be more important than histological grade. Longer follow-up and results of prospective trials are needed for definitive guidance on treatment of these patients.
In the 1998-99 flight, BOOMERanG has produced maps of ∼4% of the sky at high Galactic latitudes, at frequencies of 90, 150, 240 and 410 GHz, with resolution ≳ 10'. The faint structure of the Cosmic Microwave Background at horizon and sub-horizon scales is evident in these maps. These maps compare well to the maps recently obtained at lower frequencies by the WMAP experiment. Here we compare the amplitude and morphology of the structures observed in the two sets of maps. We also outline the polarization sensitive version of BOOMERanG, which was flown early this year to measure the linear polarization of the microwave sky at 150, 240 and 350 GHz.
The Cosmic Background Imager (CBI) is an instrument designed to make images of the cosmic microwave background radiation and to measure its statistical properties on angular scales from about 3 arc minutes to one degree (spherical harmonic scales from l ˜ 4250 down to l ˜ 400). The CBI is a 13-element interferometer mounted on a 6 meter platform operating in ten 1-GHz frequency bands from 26 GHz to 36 GHz. The instantaneous field of view of the instrument is 45 arcmin (FWHM) and its resolution ranges from 3 to 10 arcmin; larger fields can be imaged by mosaicing. At this frequency and resolution, the primary foreground is due to discrete extragalactic sources, which are monitored at the Owens Valley Radio Observatory and subtracted from the CBI visibility measurements.
The instrument has been making observations since late 1999 of both primordial CMB fluctuations and the Sunyaev-Zeldovich effect in clusters of galaxies from its site at an altitude of 5080 meters near San Pedro de Atacama, in northern Chile. Observations will continue until August 2001 or later. We present preliminary results from the first few months of observations.
BOOMERanG has recently resolved structures on the last scattering surface at redshift ˜ 1100 with high signal to noise ratio. We review the technical advances which made this possible, and we focus on the current results for maps and power spectra, with special attention to the determination of the total mass-energy density in the Universe and of other cosmological parameters.
Neighboring tidewater glaciers often exhibit asynchronous dynamic behavior, despite relatively uniform regional atmospheric and oceanic forcings. This variability may be controlled by a combination of local factors, including glacier and fjord geometry, fjord heat content and circulation, and glacier surface melt. In order to characterize and understand contrasts in adjacent tidewater glacier and fjord dynamics, we made coincident ice-ocean-atmosphere observations at high temporal resolution (minutes to weeks) within a 10 000 km2 area near Uummannaq, Greenland. Water column velocity, temperature and salinity measurements reveal systematic differences in neighboring fjords that imply contrasting circulation patterns. The observed ocean velocity and hydrography, combined with numerical modeling, suggest that subglacial discharge plays a major role in setting fjord conditions. In addition, satellite remote sensing of seasonal ice flow speed and terminus position reveal both speedup and slow-down in response to melt, as well as differences in calving style among the neighboring glaciers. Glacier force budgets and modeling also point toward subglacial discharge as a key factor in glacier behavior. For the studied region, individual glacier and fjord geometry modulate subglacial discharge, which leads to contrasts in both fjord and glacier dynamics.
We present multi-instrument observations of AR 8048, made between June 3 and June 5 1997 as part of SoHO JOP033. This active region (AR) has a sigmoid-like global shape and undergoes transient brightenings through which the stored energy is released.
Using a magneto-hydrostatic model, we compute coronal magnetic field. The large-scale magnetic lines confirm the sigmoidal characteristics of the AR. The field lines most closely matching the hotter SoHO/CDS loops extend along the quasi-separatrix-Iayers (QSLs) of the coronal field. Transition region (TR) brightenings observed with SoHO/CDS can be associated with both QSL intersections with the photosphere, and places where separatrices corresponding to bald patches (BPs, sites where field lines are tangent to the photosphere) lie at the photospheric plane. There are suggestions that the element abundances measured in the TR may depend on the type of topological structure present. TR brightenings associated with QSLs have coronal abundances, while those associated with BP separatrices have abundances closer to photospheric values.
In recognition of its special interdisciplinary character, IAU Commission 14 is linked directly to the Executive Committee. The Commission’s role is to inform the astronomical community of new developments in the diverse fields of research which involve atoms and molecules. Conversely it endeavors to sensitize the research community active in those fields to the specific needs of astronomy, especially concerning basic data and modeling tools. More generally, Commission 14 tries to foster long term relations and collaborations between the two communities and, when necessary, to alert funding authorities to the specific needs of ground and space based astronomy for specific atomic and molecular data. This report is one of the main contributions of Commission 14 to the information of the astronomical community. Several meetings concerned, at least in part, with the need and availability of atomic and molecular data for astrophysics were also sponsored or co-sponsored. In the last triennium, Commission 14 cosponsored IAU Symposium 194 “Astrochemistry: From Molecular Cloud to Planetary Systems” held in Sogwipo (Korea) from Aug. 23 to 27, 1999 and organized by Commission 34. A Joint Discussion: JD1 on “Atomic and Molecular Data for Astrophysics, New Developments, Case Studies and Future Needs” has been planned for the XXIVth IAU General Assembly in Manchester (Aug. 7-19, 2000) and cosponsored by Commissions 15, 16, 29, 34, 36, 40 and 44. Several other Joint Discussions to be held at the Manchester General Assembly are co-sponsored by this commission.
We report photometric results from 44 runs at 11 observatories during the international campaign ‘TT Ari–94’. No coherent oscillations in the frequency range 10… 900 cycle d−1 are found. The highest peaks in the power spectrum cover the wide range of 28… 139 cycle d−1. Variations occur at a few preferred time-scales rather than at one cycle length, with a possible secular decrease. In the frequency range 90… 900 cycle d−1 the power spectrum obeys a power law with slope γ ranging from 0.8 to 2.6 for different runs.
TT Ari is one of the brightest cataclysmic variables and remains one of the most interesting objects of this class. It exhibits a variety of phenomena observed at time-scales from seconds to months. A recent detailed photometric study of this object and a bibliographical overview may be found in Tremko et al. (1996). Tremko et al. (1992, 1993, 1994) discuss aspects of the TT Ari–88 campaign. Our campaign TT Ari–94 was unprecedented, as the observations were longitude-dispersed, from Japan through Turkmenia, to Europe and the American continent. Moreover, our optical data on October 7 partially overlap with the HST observations obtained by Home & Welsh (1995, private communication). The numerical results of observations obtained during these nights are shown in Table 1.
In support of the Radioactive Waste Management (RWM) safety case for a geological disposal facility (GDF) in the UK, there is a regulatory requirement to consider the likelihood and consequences of nuclear criticality. Waste packages are designed to ensure that criticality is not possible during the transport and operational phases of a GDF and for a significant period post-closure. However, over longer post-closure timescales, conditions in the GDF will evolve.
For waste packages containing spent fuel, it can be shown that, under certain conditions, package flooding could result in a type of criticality event referred to as 'quasi-steady-state' (QSS). Although unlikely, this defines a 'what-if' scenario for understanding the potential consequences of post-closure criticality. This paper provides an overview of a methodology to understand QSS criticality and its application to a spent fuel waste package.
The power of such a hypothetical criticality event is typically estimated to be a few kilowatts: comparable with international studies of similar systems and the decay heat for which waste packages are designed. This work has built confidence in the methodology and supports RWM's demonstration that post-closure criticality is not a significant concern.