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General Editor’s Preface
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp xvii-xviii
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List of Illustrations
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp xv-xvi
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A Set of Six
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp 1-233
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Abbreviations and Note on Editions
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp xxvii-xxviii
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Frontmatter
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp i-xii
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The Texts: An Essay
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp 234-325
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Appendices
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp 463-478
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Maps
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp 515-518
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Apparatus
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp 326-457
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Glossaries
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp 506-514
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Chronology
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp xxi-xxvi
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Explanatory Notes
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp 479-505
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Textual Notes
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp 458-462
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Introduction
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp xxix-lxxiv
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Contents
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp xiii-xiv
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Acknowledgements
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles, University of Hull
Book: A Set of Six
Published online: 05 August 2021
Print publication: 26 August 2021, pp xix-xx
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Characterisation of age and polarity at onset in bipolar disorder
Janos L. Kalman, Loes M. Olde Loohuis, Annabel Vreeker, Andrew McQuillin, Eli A. Stahl, Douglas Ruderfer, Maria Grigoroiu-Serbanescu, Georgia Panagiotaropoulou, Stephan Ripke, Tim B. Bigdeli, Frederike Stein, Tina Meller, Susanne Meinert, Helena Pelin, Fabian Streit, Sergi Papiol, Mark J. Adams, Rolf Adolfsson, Kristina Adorjan, Ingrid Agartz, Sofie R. Aminoff, Heike Anderson-Schmidt, Ole A. Andreassen, Raffaella Ardau, Jean-Michel Aubry, Ceylan Balaban, Nicholas Bass, Bernhard T. Baune, Frank Bellivier, Antoni Benabarre, Susanne Bengesser, Wade H Berrettini, Marco P. Boks, Evelyn J. Bromet, Katharina Brosch, Monika Budde, William Byerley, Pablo Cervantes, Catina Chillotti, Sven Cichon, Scott R. Clark, Ashley L. Comes, Aiden Corvin, William Coryell, Nick Craddock, David W. Craig, Paul E. Croarkin, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Srdjan Djurovic, Howard J. Edenberg, Mariam Al Eissa, Torbjørn Elvsåshagen, Bruno Etain, Ayman H. Fanous, Frederike Fellendorf, Alessia Fiorentino, Andreas J. Forstner, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Julie Garnham, Elliot Gershon, Michael Gill, Fernando S. Goes, Katherine Gordon-Smith, Paul Grof, Jose Guzman-Parra, Tim Hahn, Roland Hasler, Maria Heilbronner, Urs Heilbronner, Stephane Jamain, Esther Jimenez, Ian Jones, Lisa Jones, Lina Jonsson, Rene S. Kahn, John R. Kelsoe, James L. Kennedy, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Farah Klöhn-Saghatolislam, James A. Knowles, Thorsten M. Kranz, Trine Vik Lagerberg, Mikael Landen, William B. Lawson, Marion Leboyer, Qingqin S. Li, Mario Maj, Dolores Malaspina, Mirko Manchia, Fermin Mayoral, Susan L. McElroy, Melvin G. McInnis, Andrew M. McIntosh, Helena Medeiros, Ingrid Melle, Vihra Milanova, Philip B. Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Markus M. Nöthen, Tomas Novak, John I. Nurnberger, Niamh O'Brien, Kevin S. O'Connell, Claire O'Donovan, Michael C. O'Donovan, Nils Opel, Abigail Ortiz, Michael J. Owen, Erik Pålsson, Carlos Pato, Michele T. Pato, Joanna Pawlak, Julia-Katharina Pfarr, Claudia Pisanu, James B. Potash, Mark H Rapaport, Daniela Reich-Erkelenz, Andreas Reif, Eva Reininghaus, Jonathan Repple, Hélène Richard-Lepouriel, Marcella Rietschel, Kai Ringwald, Gloria Roberts, Guy Rouleau, Sabrina Schaupp, William A Scheftner, Simon Schmitt, Peter R. Schofield, K. Oliver Schubert, Eva C. Schulte, Barbara Schweizer, Fanny Senner, Giovanni Severino, Sally Sharp, Claire Slaney, Olav B. Smeland, Janet L. Sobell, Alessio Squassina, Pavla Stopkova, John Strauss, Alfonso Tortorella, Gustavo Turecki, Joanna Twarowska-Hauser, Marin Veldic, Eduard Vieta, John B. Vincent, Wei Xu, Clement C. Zai, Peter P. Zandi, Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group, International Consortium on Lithium Genetics (ConLiGen), Colombia-US Cross Disorder Collaboration in Psychiatric Genetics, Arianna Di Florio, Jordan W. Smoller, Joanna M. Biernacka, Francis J. McMahon, Martin Alda, Bertram Müller-Myhsok, Nikolaos Koutsouleris, Peter Falkai, Nelson B. Freimer, Till F.M. Andlauer, Thomas G. Schulze, Roel A. Ophoff
Journal: The British Journal of Psychiatry / Volume 219 / Issue 6 / December 2021
Published online by Cambridge University Press: 25 August 2021, pp. 659-669
Print publication: December 2021
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Background
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
Aims
To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
Method
Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
Results
Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
Conclusions
AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.

A Set of Six
Joseph Conrad
Edited by Allan H. Simmons, Michael Foster
With Owen Knowles
Published online: 05 August 2021
Print publication: 26 August 2021
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A Set of Six (1908) is one of Conrad's most versatile and varied compositions, embracing diverse interests and settings, multiple tonal qualities and a medley of short-story forms (ranging from the novella in 'The Duel' to the anecdotal tale in 'The Informer'). The volume's wide-ranging introduction offers a careful evaluation of the origins and sources of the individual stories, while also measuring their early reception as a published collection. Explanatory notes clarify literary and historical references, identify real-life places and people, and indicate borrowings and Gallicisms. The lengthy textual essay and its accompanying apparatus lay out the history of composition and publication, detailing interventions made by Conrad's typists, compositors and editors. Also included are appendices, allowing the reader first-hand access to Conrad's source material; glossaries of nautical and foreign terms; and illustrations in the form of maps and reproductions of early drafts. By returning to (and respecting) Conrad's own early manuscript and typescript forms, this edition presents the collection and its preface in a form more authoritative than any so far printed.

Heart of Darkness
from Heart of Darkness
Joseph Conrad
Edited by Owen Knowles, University of Hull, Allan H. Simmons, St Mary's University, Twickenham, London
Book: Heart of Darkness
Published online: 23 November 2018
Print publication: 27 September 2018, pp 3-83
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Appendix C - Africa in Life and Art
from Appendices
Joseph Conrad
Edited by Owen Knowles, University of Hull, Allan H. Simmons, St Mary's University, Twickenham, London
Book: Heart of Darkness
Published online: 23 November 2018
Print publication: 27 September 2018, pp 104-115
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General Editor’s Preface

List of Illustrations

A Set of Six

Abbreviations and Note on Editions

Frontmatter

The Texts: An Essay

Appendices

Maps

Apparatus

Glossaries

Chronology

Explanatory Notes

Textual Notes

Introduction

Contents

Acknowledgements

Characterisation of age and polarity at onset in bipolar disorder

A Set of Six

Heart of Darkness

Appendix C - Africa in Life and Art

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38 results