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5 - Measuring quality of life in progressive supranuclear palsy

By Anette Schrag, Caroline Selai, Niall Quinn, Jeremy Hobart, Andrew J. Lees, Irene Litvan, Anthony Lang, James Bower, David Burn

Edited by Crispin Jenkinson, University of Oxford, Michele Peters, University of Oxford, Mark B. Bromberg, University of Utah
Book: Quality of Life Measurement in Neurodegenerative and Related Conditions
Published online: 25 January 2011
Print publication: 03 February 2011, pp 52-59
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6 - Measuring quality of life in multiple system atrophy

By Anette Schrag, Caroline Selai, Christopher Mathias, Philip Low, Jeremy Hobart, Niall Quinn

Edited by Crispin Jenkinson, University of Oxford, Michele Peters, University of Oxford, Mark B. Bromberg, University of Utah
Book: Quality of Life Measurement in Neurodegenerative and Related Conditions
Published online: 25 January 2011
Print publication: 03 February 2011, pp 60-70
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List of contributors

By James Bower, Mark B. Bromberg, David Burn, Stefan Cano, Noelle E. Carlozzi, Elise Davis, Jill Dawson, Ray Fitzpatrick, Robert Harris, Jeremy Hobart, Crispin Jenkinson, Anthony Lang, Andrew J. Lees, Irene Litvan, Philip Low, Christopher Mathias, Christopher Morris, Michele Peters, Niall Quinn, Rebecca E. Ready, Anette Schrag, Caroline Selai, Amy Shelly, Elizabeth Waters

Edited by Crispin Jenkinson, University of Oxford, Michele Peters, University of Oxford, Mark B. Bromberg, University of Utah
Book: Quality of Life Measurement in Neurodegenerative and Related Conditions
Published online: 25 January 2011
Print publication: 03 February 2011, pp vii-x
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Psychotic and Depressive Symptoms in Parkinson's Disease a Study of the Growth Hormone Response to Apomorphine
John D. C. Mellers, Niall P. Quinn, Maria A. Ron
Journal: The British Journal of Psychiatry / Volume 167 / Issue 4 / October 1995
Published online by Cambridge University Press: 02 January 2018, pp. 522-526
Print publication: October 1995
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View abstract

Background
The growth hormone (GH) response to apomorphine, thought to reflect central dopaminergic receptor sensitivity, has been reported as enhanced in acute schizophrenia. We investigated this response in relation to the psychotic episodes associated with Parkinson's disease (PD).

Method
The GH response to apomorphine was measured in three groups of patients with Parkinson's disease: those currently psychotic (n = 9), those with a past history of psychosis (n = 7) and those who had never been psychotic (n = 8).

Results
Apomorphine-induced GH response was not related to psychosis but was unexpectedly associated with measures of depression.

Conclusions
Visual hallucinations were a prominent feature in the psychotic patients and the atypical nature of these psychoses might explain why we found no evidence of dopaminergic sensitivity. Serotonergic dysfunction would be in keeping with this. Dopaminergic mechanisms may contribute to the minor depressive symptomatology seen in PD.