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18 results

  • Chapter 9 - A Neuroimaging Network-Level Approach to Drug-Resistant Epilepsy
  • Edited by Rod C. Scott, University of Vermont, J. Matthew Mahoney, University of Vermont
  • Book: A Complex Systems Approach to Epilepsy
  • Published online: 06 January 2023
  • Print publication: 26 January 2023, pp 127-134
  • View extract

    Summary

    Epilepsy affects approximately 1% of the population [1]. Although generally treatable, up to 30% of patients do not achieve seizure freedom from anticonvulsive medication alone. Due to its relationship with cognitive abilities [2], quality of life [3], and the associated risk of premature death [4], drug-refractory epilepsy should be treated promptly. Temporal lobe epilepsy (TLE) associated with mesiotemporal sclerosis [5] and extra-temporal lobe epilepsy related to focal cortical dysplasia (FCD) [6] constitute the most common refractory epilepsy syndromes. Surgical resection of these lesions remains the treatment of choice [7], with success rates approaching 80% [8]. By allowing the detection of epileptogenic lesions and offering system-level mechanisms of the disease process, MRI has shifted the field from electro-clinical correlations toward a multidisciplinary approach.

Imaging Biomarkers in Epilepsy
  • Imaging Biomarkers in Epilepsy
  • Edited by Andrea Bernasconi, Neda Bernasconi, Matthias Koepp
  • Published online: 07 January 2019
  • Print publication: 10 January 2019
  • View description
    Epilepsy is a prevalent and serious neurological disorder. This vital textbook addresses the role of neuroimaging as a unique tool to provide in vivo biomarkers aimed at furthering our understanding of causes and consequences of epilepsy in a day-to-day clinical context. Unique in its approach, this translational book presents a critical appraisal of advanced pre-clinical biomarkers that allows capturing epileptogenesis at molecular, cellular, and neuronal system levels. The book is divided into four sections. Part I includes a series of chapters focused on imaging of early disease stages. Part II discusses lesion detection and network analysis methods. Part III focuses on imaging methods used to predict response to antiepileptic drugs and surgery. Finally, Part IV presents imaging techniques used to evaluate disease consequence.