A recent review of the prevalence of dementia in all world regions revealed a particular paucity of data from the Middle Eastern region (Ferri et al., 2005). Iran is one of the largest countries in this region, with a population of 70 million, of whom 5.2% are aged 65 years and over and where life expectancy is already 71 years (www.amar.ir – Iranian Government Statistics site). Our best estimates suggest that there may be nearly 200,000 people living with dementia in Iran at the moment (Ferri et al., 2005). The 10/66 Dementia Research Group developed and validated a cultural- and education-fair dementia diagnosis in 26 centers worldwide (Prince et al., 2003). We have now assessed the feasibility and validity of a Farsi version of the 10/66 dementia diagnostic system in Ekbatan, Tehran, Iran.