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Geometrical work piece deviations are unavoidable and directly affect the function and quality of technological products. Tolerance management is regarded as a crucial subtask of the development of technological products, because it ensures the function as well as a sufficient product quality while maintaining reasonable production costs. That means, that geometric tolerances as an essential part of the product description greatly affect the functional capability, manufacturability, mountability, verifiability and the costs of the final product. The research group FOR 2271 was founded to enable the computer-aided specification of tolerances, which meet the requirements of production, assembly, verification and function by close cooperation between the departments responsible for product design, assembly and metrology. The aim of this contribution is to determine the manufacturing process scatter as well as the measurement uncertainty and establish ways and means to include that information into efficient meta-models, ultimately enabling improved and accurate tolerance analyses.
The phenomenon of buying-shopping disorder (BSD) was described over 100 years ago. Definitions of BSD refer to extreme preoccupation with shopping and buying, to impulses to purchase that are experienced as irresistible, and to recurrent maladaptive buying excesses that lead to distress and impairments. Efforts to stop BSD episodes are unsuccessful, despite the awareness of repeated break-downs in self-regulation, experiences of post-purchase guilt and regret, comorbid psychiatric disorders, reduced quality of life, familial discord, work impairment, financial problems, and other negative consequences. A recent meta-analysis indicated an estimated point prevalence of BSD of 5%. In this narrative review, the authors offer a perspective to consider BSD as a mental health condition and to classify this disorder as a behavioral addiction, based on both research data and on long-standing clinical experience.
Gray matter (GM) ‘pseudoatrophy’ is well-documented in patients with anorexia nervosa (AN), but changes in white matter (WM) are less well understood. Here we investigated the dynamics of microstructural WM brain changes in AN patients during short-term weight restoration in a combined longitudinal and cross-sectional study design.
Diffusion-weighted images were acquired in young AN patients before (acAN-Tp1, n = 56) and after (acAN-Tp2, n = 44) short-term weight restoration as well as in age-matched healthy controls (HC, n = 60). Images were processed using Tract-Based-Spatial-Statistics to compare fractional anisotropy (FA) across groups and timepoints.
In the cross-sectional comparison, FA was significantly reduced in the callosal body in acAN-Tp1 compared with HC, while no differences were found between acAN-Tp2 and HC. In the longitudinal arm, FA increased with weight gain in acAN-Tp2 relative to acAN-Tp1 in large parts of the callosal body and the fornix, while it decreased in the right corticospinal tract.
Our findings reveal that dynamic, bidirectional changes in WM microstructure in young underweight patients with AN can be reversed with brief weight restoration therapy. These results parallel those previously observed in GM and suggest that alterations in WM in non-chronic AN are also state-dependent and rapidly reversible with successful intervention.
Behavioural public policy (BPP) has come under fire by critics who claim that it is illiberal. Some authors recently suggest that there is a type of BPP – boosting – that is not as vulnerable to this normative critique. Our paper challenges this claim: there's no non-circular way to draw the distinction between nudge and boost that would make the normative difference required to infer the permissibility of a policy intervention from its type-membership. We consider two strategies: paradigmatic examples and causal mechanisms. We conclude by sketching some suggestions about the right way to approach the normative issues.
SHIFTING THE POLITICS OF BELONGING: MEDIA INTERVENTIONS AND POSSIBILITIES FOR TRANSFORMATION
Timothy Marjoribanks, Swinburne University of Technology,
Denis Muller, senior lecturer and honorary fellow at the Centre for Advancing Journalism at the University of Melbourne,
Michael Gawenda, a foreign correspondent based in London and in Washington
Media interventions aim to disrupt and reshape power relations between the media industry, including professional journalists, and other participants in society. The intervention that is the focus of this chapter, the AuSud media intervention, was designed to engage mainstream media and to influence the ways in which Sudanese Australian people are portrayed by the Australian media. As part of this process, the intervention's objective was to enable Sudanese Australians to put forward their own voice in the media and to provide them with a means of being heard. It sought to do this by training Sudanese Australians in journalism, by helping them to create a website through which to disseminate their journalistic work and by providing them with connections into Australian institutions such as the Australian Broadcasting Corporation (ABC) and Victoria Police. In addition, by recruiting journalists from established and mainstream media institutions to help realize these objectives, the intervention aimed to transform mainstream media journalists’ perceptions and stereotypes of the Sudanese Australian community.
The media intervention that is the focus of this chapter had two distinctive features. First, it aimed to provide professional journalistic training to members of a newly arrived community who were being harassed by institutions of power, notably the police, parliamentarians and the established media, in order to give them a voice. Second, it gave them direct links into those institutions that were doing them the most harm, the police and the media, to allow the community to be heard directly.
Within this context, this chapter asks two main questions: What were the defining features and outcomes of the AuSud media intervention, and what challenges did the intervention face? What are the lessons of the AuSud media intervention for other interventions? This chapter argues that the AuSud media intervention engaged successfully to some extent with questions of voice and listening, but that it faced profound challenges around ownership and sustainability. These outcomes reveal the importance of analysing media interventions as sites of power and as processes that unfold over time.
This article assesses the causes of the crisis of detention in Latin America. It is argued that this crisis, which manifests itself in overpopulation of the region's prison systems, deficient infrastructure, prison informality and violence propelled ultimately by political processes, is mostly related to, on the one hand, disastrous human rights conditions inside Latin American prisons, and on other, the political denial of these conditions. This denial produces a state of institutional abandonment that is preserved by the interests of politicians and bureaucrats, who are engaged in denying prison violence and human rights abuses while simultaneously calling for more punishment and imprisonment.
Depression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity.
To confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.
The sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for association between rs9939609 and body mass index (BMI), and for the interaction between rs9939609 and depression status for an effect on BMI. Fixed and random effects meta-analyses were performed using METASOFT.
In the replication cohorts, we observed a significant interaction between FTO, BMI and depression with fixed effects meta-analysis (β=0.12, P = 2.7 × 10−4) and with the Han/Eskin random effects method (P = 1.4 × 10−7) but not with traditional random effects (β = 0.1, P = 0.35). When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model (P = 6.9 × 10−8). On average, carriers of the risk allele who have depression have a 2.2% higher BMI for each risk allele, over and above the main effect of FTO.
This meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI. The findings provide a useful starting point in understanding the biological mechanism involved in the association between obesity and depression.
Lithium sulfur (Li–S) batteries have the potential to provide higher energy storage density at lower cost than conventional lithium ion batteries. A key challenge for Li–S batteries is the loss of sulfur to the electrolyte during cycling. This loss can be mitigated by sequestering the sulfur in nanostructured carbon–sulfur composites. The nanoscale characterization of the sulfur distribution within these complex nanostructured electrodes is normally performed by electron microscopy, but sulfur sublimates and redistributes in the high-vacuum conditions of conventional electron microscopes. The resulting sublimation artifacts render characterization of sulfur in conventional electron microscopes problematic and unreliable. Here, we demonstrate two techniques, cryogenic transmission electron microscopy (cryo-TEM) and scanning electron microscopy in air (airSEM), that enable the reliable characterization of sulfur across multiple length scales by suppressing sulfur sublimation. We use cryo-TEM and airSEM to examine carbon–sulfur composites synthesized for use as Li–S battery cathodes, noting several cases where the commonly employed sulfur melt infusion method is highly inefficient at infiltrating sulfur into porous carbon hosts.