Ancient granite columns have been a pervasive element in the architecture of Rome since the Imperial era. However, in the fifteenth century, just as the effort to revive Antiquity intensified, these ubiquitous and durable ancient columns fell out of use. It was instead the stone travertine that became the columnar material of choice. Yet, just as quickly as this change occurred, within an exceptionally short period of thirty years, beginning with the construction of the Palazzo della Cancelleria courtyard, Rome saw a renascence in their application. While little has been made of this material shift, this article argues that the sudden extensive employment of spoliated granite columns was a crucial component in the recovery of a distinctly local Roman Antiquity. It was through the use and transformation of spolia that builders and patrons attempted to create an architecture that not only recalled Antiquity, but resubstantiated it, literally making it whole again.