The impact of individual symptoms reported post-COVID-19 on subjective well-being (SWB) is unknown. We described associations between SWB and selected reported symptoms following SARS-CoV-2 infection. We analysed reported symptoms and subjective well being from 2295 participants (of which 576 reporting previous infection) in an ongoing longitudinal cohort study taking place in Israel. We estimated changes in SWB associated with reported selected symptoms at three follow-up time points (3–6, 6–12 and 12–18 months post infection) among participants reporting previous SARS-CoV-2 infection, adjusted for key demographic variables, using linear regression. Our results suggest that the biggest and most sustained changes in SWB stems from non-specific symptoms (fatigue −7.7 percentage points (pp), confusion/ lack of concentration −10.7 pp, and sleep disorders −11.5pp, P < 0.005), whereas the effect of system-specific symptoms, such as musculoskeletal symptoms (weakness in muscles and muscle pain) on SWB, are less profound and more transient. Taking a similar approach for other symptoms and following individuals over time to describe trends in SWB changes attributable to specific symptoms will help understand the post-acute phase of COVID-19 and how it should be defined and better managed. Post-acute COVID19 symptoms were associated with a significant decrease in subjective well being up to 18 months after initial infection

Between December 2020 and March 2021, we measured anti-SARS-CoV-2 IgG titres among 725 Israeli hospital workers vaccinated against COVID-19. Infection post-dose 1 vaccination did not increase IgG titres, and individuals infected post-dose 1 had IgG levels comparable to never-infected individuals who received a single dose, lower than fully vaccinated, never-infected individuals. This suggests dose 2, currently not offered to those infected post-dose 1, may be required in these individuals. Larger studies should confirm whether individuals infected post-dose 1 need the second.

Emergency preparedness is a continuous quality improvement process through which roles and responsibilities are defined to effectively anticipate, respond to, and recover from the impact of emergencies. This process results in documented plans that provide a backbone structure for developing the core capacities to address health threats. Nevertheless, several barriers can impair an effective preparedness planning, as it needs a 360° perspective to address each component according to the best evidence and practice. Preparedness planning shares common principles with health technology assessment (HTA) as both encompass a multidisciplinary and multistakeholder approach, follow an iterative cycle, adopt a 360° perspective on the impact of intervention measures, and conclude with decision-making support. Our “Perspective” illustrates how each HTA domain can address different component(s) of a preparedness plan that can indeed be seen as a container of multiple HTAs, which can then be used to populate the entire plan itself. This approach can allow one to overcome preparedness barriers, providing an independent, systematic, and robust tool to address the components and ensuring a comprehensive evaluation of their value in the mitigation of the impact of emergencies.

The TEDI (TripleSpec - Exoplanet Discovery Instrument) is a dedicated instrument for the near-infrared radial velocity search for planetary companions to low-mass stars with the goal of achieving meters-per-second radial velocity precision. Heretofore, such planet searches have been limited almost entirely to the optical band and to stars that are bright in this band. Consequently, knowledge about planetary companions to the populous but visibly faint low-mass stars is limited. In addition to the opportunity afforded by precision radial velocity searches directly for planets around low mass stars, transits around the smallest M dwarfs offer a chance to detect the smallest possible planets in the habitable zones of the parent stars. As has been the the case with followup of planet candidates detected by the transit method requiring radial velocity confirmation, the capability to undertake efficient precision radial velocity measurements of mid-late M dwarfs will be required. TEDI has been commissioned on the Palomar 200” telescope in December 2007, and is currently in a science verification phase.

Learning and performance on a ballistic task were investigated in children with spina bifida meningomyelocele (SBM), with either upper level spinal lesions (n = 21) or lower level spinal lesions (n = 81), and in typically developing controls (n = 35). Participants completed three phases (20 trials each) of an elbow goniometer task that required a ballistic arm movement to move a cursor to one of two target positions on a screen, including (1) an initial learning phase, (2) an adaptation phase with a gain change such that recalibration of the ballistic arm movement was required, and (3) a learning reactivation phase under the original gain condition. Initial error rate, asymptotic error rate, and learning rate did not differ significantly between the SBM and control groups. Relative to controls, the SBM group had reduced volumes in the cerebellar hemispheres and pericallosal gray matter (the region including the basal ganglia), although only the pericallosal gray matter was significantly correlated with motor adaptation. Congenital cerebellar dysmorphology is associated with preserved motor skill learning on voluntary, nonreflexive tasks in children with SBM, in whom the relative roles of the cerebellum and basal ganglia may differ from those in the adult brain. (JINS, 2006, 12, 598–608.)

We are developing a device, the MEMS flux concentrator, that will greatly decrease the effect of 1/f noise in magnetic sensors. It does this by modulating the incoming signal and thus shifting the operating frequency of the sensor. This is accomplished by placing flux concentrators on MEMS structures that oscillate at kHz frequencies. Depending upon the sensor, shifting the operating frequency reduces the 1/f noise by one to three orders of magnitude at one Hz. We have succeeded in fabricating the necessary MEMS structures and observing the desired kHz normal mode resonant frequency. Only microwatts are required to drive the motion. We have used spin valves for our magnetic sensors. The measured field enhancement provided by the flux concentrators agrees to within 3% with the value estimated from finite element calculations. Noise measurements provide strong evidence that the device is likely to reduce the effect of 1/f noise. Flip chip bonding is likely to allow us to fabricate complete, fully functioning sensors.

The cerebellum is part of a neural circuit involved in procedural motor learning. We examined how congenital cerebellar malformations affect mirror drawing performance, a procedural learning task that involves learning to trace the outline of a star while looking at the reflection of the star in a mirror. Participants were 88 children with spina bifida myelomeningocele, a neural tube defect that results in lesions of the spinal cord, dysmorphology of the cerebellum, and requires shunt treatment for hydrocephalus, and 35 typically developing controls. Participants completed 10 trials in the morning and 10 trials following a 3-hr delay. Although children with spina bifida myelomeningocele were initially slower at tracing and made more errors than controls, all participants improved their performance of the task, as demonstrated by increased speed and accuracy across trials. Moreover, degree of cerebellar dysmorphology was not correlated with level of performance, rate of acquisition, or retention of mirror drawing. The results suggest that congenital cerebellar dysmorphology in spina bifida does not impair motor skill learning as measured by acquisition and retention of the mirror drawing task. (JINS, 2004, 10, 877–887.)

A collection P of bounded linear operators in l2 is constructed in such a manner that given any separable metric space X, and any countable collection F of continuous self-maps of X, there is a homeomorphism h of X onto a subset of l2 such that for each f ∈ F there is P ∈ P with hf = Ph.

While similar results were obtained by Baayen and Dc Groot, our construction makes it possible to impose additional conditions on h (depending on F). For example, if all the members of F are uniformly continuous then h too can be made uniformly continuous.