At Lago Buenos Aires, Argentina, 10Be, 26Al, and 40Ar/39Ar ages range from 190,000 to 109,000 yr for two moraines deposited prior to the last glaciation, 23,000�16,000 yr ago. Two approaches, maximum boulder ages assuming no erosion, and the average age of all boulders and an erosion rate of 1.4 mm/103 yr, both yield a common estimate age of 150,000�140,000 yr for the two moraines. The erosion rate estimate derives from 10Be and 26Al concentrations in old erratics, deposited on moraines that are >760,000 yr old on the basis of interbedded 40Ar/39Ar dated lavas. The new cosmogenic ages indicate that a major glaciation during marine oxygen isotope stage 6 occurred in the mid-latitude Andes. The next five youngest moraines correspond to stage 2. There is no preserved record of a glacial advance during stage 4. The distribution of dated boulders and their ages suggest that at least one major glaciation occurred between 760,000 and >200,000 yr ago. The mid-latitude Patagonian glacial record, which is well preserved because of low erosion rates, indicates that during the last two glacial cycles major glaciations in the southern Andes have been in phase with growth and decay of Northern Hemisphere ice sheets, especially at the 100,000 yr periodicity. Thus, glacial maxima are global in nature and are ultimately paced by small changes in Northern Hemisphere insolation.