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Microbial reduction of clay mineral structural Fe(III) decreases the swelling of nontronite gels, most importantly at intermediate oxidation states (40 to 80 cmol Fe(II) kg−1 clay). The purpose of this study was to establish whether microbial reduction of structural Fe(III) decreased the swelling of other Fe-bearing smectites and to discern the influence that organic compounds of microbial origin (bacterial cells, cell fragments and/or exudates) may have on clay swelling and texture. Structural Fe(III) was reduced by incubating smectite suspensions with either a combination of Pseudomonas bacteria or a mixture of anaerobic bacteria. The influence of organics on clay swelling was estimated on smectites suspended in either organic or inorganic media in the absence of bacteria. The gravimetric water content of the reduced clay gels equilibrated at various applied pressures was recorded as a function of Fe oxidation state. Transmission electron microscopy (TEM) was employed to determine the influence of bacteria and type of media on the texture of reduced smectite gels. Reduction of structural Fe(III) by bacteria decreased the swelling pressure of all Fe-bearing smectites. Increased clay swelling, due to the presence of organics (organic medium, exudates or cell fragments), was correlated to the total Fe content, the extent of structural Fe reduction, as well as the initial swelling characteristics of the Fe-bearing smectites. High structural Fe(II) contents (>50 cmol Fe(II) kg−1) resulted in increased attractive forces between clay platelets that decreased clay swelling, even in organic medium suspensions. Microbial reduction resulted in increased face-face association of individual clay layers, forming larger and more distinct crystallite subunits than in nonreduced clay gels. But, perhaps more importantly, microbial reduction of structural Fe(III) resulted in an increased association between crystallite subunits and, thus, an overall larger particle size and pore size distribution, due to the interaction of bacteria ceils, cell fragments and organic exudates.
If a flat, horizontal, plate settles onto a flat surface, it is known that the gap $h$ decreases with time $t$ as a power law: $h\sim t^{-1/2}$. We consider what happens if the plate is not initially horizontal, and/or the centre of mass is not symmetrically positioned: does one edge contact the surface in finite time, or does the plate approach the horizontal without making contact? The dynamics of this system is analysed and shown to be remarkably complex. We find that, depending upon the initial position of the plate and the position of the centre of force, the plate might either make contact in finite time or settle progressively without ever making contact. Our results show an excellent agreement between analytical exact solutions, asymptotic solutions and numerical studies of the lubrication equations.
Edited by
Dennis S. Chi, Memorial Sloan-Kettering Cancer Center, New York,Nisha Lakhi, Richmond University Medical Center, Staten Island,Nicoletta Colombo, University of Milan-Bicocca
Intra-observer variability in defining clinic-pathologic risk factors and the heterogeneity of outcomes has led to challenges in defining the optimal management for endometrial cancer (EC) patients. The Cancer Genome Atlas identification of four distinct molecular subgroups has greatly enhanced our understanding of the biology of EC. Integration of histo-molecular information provides more accurate characterization of disease subgroups and prognosis. This facilitates prognostication and optimization of adjuvant therapy decisions, avoiding the potential for both under and over treatment. Molecular profiling also delivers the potential to predict therapy response and define the optimal approach for a given disease subtype in both adjuvant and recurrent disease settings. We can also more accurately to identify patients and families with Lynch syndrome and institute risk reducing measures. Molecular profiling facilitates more precise and accurate management of our patients with EC and it should become integrated into routine care.
Despite a long and venerable tradition, the material constitution almost disappeared from constitutional scholarship after the Second World War. Its marginalisation saw the rise of a normative and legalistic style in constitutional law that neglected the role of social reality and political economy. This collection not only retrieves the history and development of the concept of the material constitution, but it tests its theoretical and practical relevance in the contemporary world. With essays from a diverse range of contributors, the collection demonstrates that the material constitution speaks to several pressing issues, from the significance of economic development in constitutional orders to questions of constitutional identity. Offering original analyses supported by international case studies, this book develops a new model of constitutional reality, one that informs our understanding of the world in profound ways.
The aims of this chapter are, first, to track the development of the notion of the material constitution in selected authors associated with Western Marxism and, second, to explain its intermittent presence in the Marxist canon.The chapter focuses on four turning points in the social and intellectual history of the material constitution: its Marxist origins in the second half of the nineteenth century (Karl Marx and Ferdinand Lassalle, who coined the term); the crucial years of the Soviet revolution and the First World War(Vladimir Lenin and Rosa Luxemburg); the interwar period (Antonio Gramsci); and the tail end of the twentieth century (Étienne Balibar and Antonio Negri). At each turning point, a certain slack between the concrete constitutional order and the codified or written constitution has pushed scholars to revisit the material constitution. Although the chapter registers the decline of interest in the material constitution after the Second World War, it also underscores that the series of crises over the last two decades have again pushed the notion to the centre stage of constitutional enquiry. The chapter thus highlights the insight offered by these authors for understanding the material constitution in the twenty-first century.
This introduction is focused on two main points. First, it provides an explanation of the continued relevance of the notion of the material constitution in constitutional studies and beyond. It does so by showing the added epistemic value of the notion compared to other conceptions: the political constitutions, the living constitution, the mixed constitution. Second, it gives an overview of the contents of the Handbook by explaining its organisation and its thematic unities.
This response to critics gives me the opportunity to develop some aspects of the argument in Authoritarian Liberalism and the Transformation of Modern Europe. I do so by foregrounding the concept of political freedom, articulated by Franz Neumann. Authoritarian liberalism operates by suppressing political freedom and democracy. First making its mark in late Weimar, authoritarian liberalism is constructed in a more passive fashion in the decades after the Second Word War. Although it is contested by social movements in the 1960’s and 70’s, it is ultimately reinforced in the turn to neoliberalism. This reaches its apogee at the Treaty of Maastricht, with the de-politicization of economic and monetary union and the deepening and widening of the European Union. German ordoliberalism, which functions as an ideological support to authoritarian liberalism, is instructive, but is only a part of this story; Germany is at most ‘semi-hegemonic’ in Europe. Authoritarian liberalism operates instead through limiting the constitutional imagination in all member states of the Union. I end with some reflections on Walter Benjamin, whose philosophy of history inspired the cover of the book.
To achieve the elimination of the hepatitis C virus (HCV), sustained and sufficient levels of HCV testing is critical. The purpose of this study was to assess trends in testing and evaluate the effectiveness of strategies to diagnose people living with HCV. Data were from 12 primary care clinics in Victoria, Australia, that provide targeted services to people who inject drugs (PWID), alongside general health care. This ecological study spanned 2009–2019 and included analyses of trends in annual numbers of HCV antibody tests among individuals with no previous positive HCV antibody test recorded and annual test yield (positive HCV antibody tests/all HCV antibody tests). Generalised linear models estimated the association between count outcomes (HCV antibody tests and positive HCV antibody tests) and time, and χ2 test assessed the trend in test yield. A total of 44 889 HCV antibody tests were conducted 2009–2019; test numbers increased 6% annually on average [95% confidence interval (CI) 4–9]. Test yield declined from 2009 (21%) to 2019 (9%) (χ2P = <0.01). In more recent years (2013–2019) annual test yield remained relatively stable. Modest increases in HCV antibody testing and stable but high test yield within clinics delivering services to PWID highlights testing strategies are resulting in people are being diagnosed however further increases in the testing of people at risk of HCV or living with HCV may be needed to reach Australia's HCV elimination goals.
The Pinnacle3 Auto-Planning (AP) package is an automated inverse planning tool employing a multi-sequence optimisation algorithm. The nature of the optimisation aims to improve the overall quality of radiotherapy plans but at the same time may produce higher modulation, increasing plan complexity and challenging linear accelerator delivery capability.
Methods and materials:
Thirty patients previously treated with intensity-modulated radiotherapy (IMRT) to the prostate with or without pelvic lymph node irradiation were replanned with locally developed AP techniques for step-and-shoot IMRT (AP-IMRT) and volumetric-modulated arc therapy (AP-VMAT). Each case was also planned with VMAT using conventional inverse planning. The patient cohort was separated into two groups, those with a single primary target volume (PTV) and those with dual PTVs of differing prescription dose levels. Plan complexity was assessed using the modulation complexity score.
Results:
Plans produced with AP provided equivalent or better dose coverage to target volumes whilst effectively reducing organ at risk (OAR) doses. For IMRT plans, the use of AP resulted in a mean reduction in bladder V50Gy by 4·2 and 4·7 % (p ≤ 0·01) and V40Gy by 4·8 and 11·3 % (p < 0·01) in the single and dual dose level cohorts, respectively. For the rectum, V70Gy, V60Gy and V40Gy were all reduced in the dual dose level AP-VMAT plans by an average of 2·0, 2·7 and 7·3 % (p < 0·01), respectively. A small increase in plan complexity was observed only in dual dose level AP plans.
Findings:
The automated nature of AP led to high quality treatment plans with improvement in OAR sparing and minimised the variation in achievable dose planning metrics when compared to the conventional inverse planning approach.
Constitutional pluralism is a theory for the post-sovereign European state. This only makes sense historically, emerging out of postwar European reconstruction through the repression of popular sovereignty and restraining of democracy, including through the project of European integration. It became unsettled at Maastricht and evolved from a series of irritants into a full-blown crisis in the recent decade, with sovereignty claims returning both from the bottom-up and the top-down, to the extent that we can legitimately ask whether we are now moving ‘beyond the post-sovereign state’? Constitutional pluralist literature fails to capture this in that evades material issues of democracy and political economy.
In the period spanning nearly a decade from the beginning of the financial crisis to the present, the constitutional state and state system in Europe has been affected by a series of challenges to its authority and legitimacy. With regard to the European Union, these challenges are fundamental in that they go to the very existence of the project and to the values it professes to be founded on. They seem increasingly interconnected to the EU and the trajectory of integration rather than merely external to it. For the moment, the EU remains relatively resilient; outside of the UK, appetite for ending the experiment mostly inhabits the political fringes, although even in core countries, anti-European pressures are mounting and Eurosceptic parties are on the ascendency. What is clear is that the challenges to the current system go as much to the legitimacy of domestic regimes and their political authority as to the EU itself, not least from the fragmentary pressures on the state from below in the context of subnational claims to autonomy. In short, the crisis of authority is not merely of the EU but of the regional state system and the governing order in Europe.