To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The chapter will summarize our current understanding of the neuronal and neurochemical basis of hypnogenesis. The hypothesis of the localization of a hypnogenic mechanism in the mammalian hypothalamic preoptic area (POA) was first proposed by von Economo more than 70 years ago (von Economo, 1930). This hypothesis has been confirmed by findings that experimental POA lesions suppress sleep, and that electrical, chemical, and thermal POA stimulation induce sleep (reviewed by McGinty & Szymusiak, 2001). Unit recording studies have identified POA neurons that exhibit increased activity during NREM sleep, REM sleep, or both. These sleep-active neurons are hypothesized to be the substrate of the hypnogenic mechanism. The past decade has seen substantial progress in the further description of this hypnogenic system; we summarize this progress in this chapter.
Localization of sleep-active neurons within the POA
Studies of sleep-active neuronal discharge across the sleep–wake cycle in freely moving animals provide important information about the hypnogenic process (see below) but, because of sampling limitations, are not suitable for systematic mapping of the exact locations of putative hypnogenic neurons. The application of the c-Fos immunoreactivity (IR) method to map sleep-active neurons has stimulated several advances. C-Fos IR is a marker of neuronal activation in most brain sites; immunohistochemically labeled neurons can be mapped systematically.
Email your librarian or administrator to recommend adding this to your organisation's collection.