It has been known since many decades that galaxy interactions can induce star formation (hereafter SF) enhancements and that one of the driving mechanisms of this enhancement is related to gas inflows into the central galaxy regions, induced by asymmetries in the stellar component, like bars. In the last years many evidences have been accumulating, showing that interacting pairs have central gas-phase metallicities lower than those of field galaxies, by ~0.2–0.3 dex on average. These diluted ISM metallicities have been explained as the result of inflows of metal-poor gas from the outer disk to the galaxy central regions. A number of questions arises: What's the timing and the duration of this dilution? How and when does the SF induced by the gas inflow enrich the circum-nuclear gas with re-processed material? Is there any correlation between the timing and strength of the dilution and the timing and intensity of the SF? By means of Tree-SPH simulations of galaxy major interactions, we have studied the effect that gas inflows have on the ISM dilution, and the effect that the induced SF has, subsequently, in re-enriching the nuclear gas. In this contribution, we present the main results of this study.