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No studies to date have investigated cumulative anticholinergic exposure
and its effects in adults with intellectual disabilities.
To determine the cumulative exposure to anticholinergics and the factors
associated with high exposure.
A modified Anticholinergic Cognitive Burden (ACB) scale score was
calculated for a representative cohort of 736 people over 40 years old
with intellectual disabilities, and associations with demographic and
clinical factors assessed.
Age over 65 years was associated with higher exposure (ACB 1–4 odds ratio
(OR) = 3.28, 95% CI 1.49–7.28, ACB 5+ OR = 3.08, 95% CI 1.20–7.63), as
was a mental health condition (ACB 1–4 OR = 9.79, 95% CI 5.63–17.02, ACB
5+ OR = 23.74, 95% CI 12.29–45.83). Daytime drowsiness was associated
with higher ACB (P<0.001) and chronic constipation
reported more frequently (26.6% ACB 5+ v. 7.5% ACB 0,
Older people with intellectual disabilities and with mental health
conditions were exposed to high anticholinergic burden. This was
associated with daytime dozing and constipation.
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