The idea of moral enhancement has no clear meaning. This is because the idea of being moral has no clear meaning. There are numerous ways in which one might go astray, morally speaking, and each of these ways, in turn, fragments on further analysis. The concept of moral enhancement is as broad, messy, and mottled as the reasons why people behave badly. This mottled character of moral failure calls into question the feasibility of (non-traditional) programmes of moral enhancement.

Alterations in the composition and metabolic activity of the gut microbiota appear to contribute to the development of obesity and associated metabolic diseases. However, the extent of this relationship remains unknown. Modulating the gut microbiota with non-digestible carbohydrates (NDC) may exert anti-obesogenic effects through various metabolic pathways including changes to appetite regulation, glucose and lipid metabolism and inflammation. The NDC vary in physicochemical structure and this may govern their physical properties and fermentation by specific gut bacterial populations. Much research in this area has focused on established prebiotics, especially fructans (i.e. inulin and fructo-oligosaccharides); however, there is increasing interest in the metabolic effects of other NDC, such as resistant dextrin. Data presented in this review provide evidence from mechanistic and intervention studies that certain fermentable NDC, including resistant dextrin, are able to modulate the gut microbiota and may alter metabolic process associated with obesity, including appetite regulation, energy and lipid metabolism and inflammation. To confirm these effects and elucidate the responsible mechanisms, further well-controlled human intervention studies are required to investigate the impact of NDC on the composition and function of the gut microbiota and at the same time determine concomitant effects on host metabolism and physiology.

Laboratory apparatus and techniques are described for the rearing and insecticidal treatment of whitefly, Bemisia tabaci Gennadius, under simulated field conditions. Insects were reared on cotton plants inside large population cages and treated from an overhead sprayer. The effects of these treatments were assessed accurately, without interfering with insects or plants, by monitoring adult numbers with an endoscope over one or more generations. Examples of single-generation and multiple-generation tests with cypermethrin are described. The apparatus is suitable for testing strategies for delaying the selection of resistance (e.g. using insecticides applied singly, alternately, or in mixture, at various application rates and frequencies), for controlling populations already resistant to insecticides, and for integrated pest management using chemical and biological control agents together.

Cypermethrin, profenofos, and a mixture of these insecticides were evaluated against resistant and susceptible whitefly, Bemisa tabaci Gennadius, from Sudan using (a) laboratory technology which simulates the aerial spraying of whitefly infestations on cotton crops, and (b) standard residue-bioassays. Simulator tests in which adult cohorts were given a single insecticide treatment produced results that were unexpected on the basis of standard bioassay data. Resistance to cypermethrin, for example, was expressed in the bioassays but not in the simulator, resistance to profenofos was expressed both in bioassays and in the simulator, resistance to the mixture was expressed in the simulator but in the bioassay the chemicals acted synergistically and there was no resistance. Repeated treatment of resistant populations, comprised of all life stages, over three generations gave further unpredicted results: cypermethrin failed to contact larvae on the under surfaces of leaves and hence did not prevent population growth; profenofos sprayed at field rates controlled all life-stages (despite the expression of resistance) provided the insecticide vapour was not dissipated. An alternation of cypermethrin and profenofos – cypermethrin timed against maximum adult emergence and profenofos timed to coincide with high larval densities – gave the best control. The disparities between the simulator experiments and standard bioassays suggest that techniques simulating the field treatment of all life-stages are better suited for evaluating the practical significance of resistance and potential curative strategies.

Jets arising from rivers, streams and tidal flows entering still waters differ from most experimental studies of jets both in aspect ratio and in the presence of a solid bottom boundary and an upper free surface. Despite these differences, the applicability of experimental jet studies to these systems remains largely untested by either field or realistically scaled experimental studies. Here we present experimental results for a wall-bounded plane jet scaled to jets created by flow discharging into floodplain lakes. A characteristic feature of both our prototype and experimental jets is the presence of large-scale meandering turbulent structures that span the width of the jets. In our experimental jets, we observe self-similarity in the distribution of mean streamwise velocities by a distance of six channel widths downstream of the jet outlet. After a distance of nine channel widths the velocity decay and the spreading rates largely agree with prior experimental results for plane jets. The magnitudes and distributions of the cross-stream velocity and lateral shear stresses approach self-preserving conditions in the upper half of the flow, but decrease in magnitude, and deviate from self-preserving distributions with proximity to the bed. The presence of the meandering structure has little influence on the mean structure of the jet, but dominates the jet turbulence. A comparison of turbulence analysed at time scales both greater than and less than the period of the meandering structure indicates that these structures increase turbulence intensities by 3–5 times, and produce lateral shear stresses and momentum diffusivities that are one and two orders of magnitude greater, respectively, than turbulence generated by bed friction alone.