It is acknowledged that health technology assessment (HTA) is an inherently value-based activity that makes use of normative reasoning alongside empirical evidence. But the language used to conceptualise and articulate HTA's normative aspects is demonstrably unnuanced, imprecise, and inconsistently employed, undermining transparency and preventing proper scrutiny of the rationales on which decisions are based. This paper – developed through a cross-disciplinary collaboration of 24 researchers with expertise in healthcare priority-setting – seeks to address this problem by offering a clear definition of key terms and distinguishing between the types of normative commitment invoked during HTA, thus providing a novel conceptual framework for the articulation of reasoning. Through application to a hypothetical case, it is illustrated how this framework can operate as a practical tool through which HTA practitioners and policymakers can enhance the transparency and coherence of their decision-making, while enabling others to hold them more easily to account. The framework is offered as a starting point for further discussion amongst those with a desire to enhance the legitimacy and fairness of HTA by facilitating practical public reasoning, in which decisions are made on behalf of the public, in public view, through a chain of reasoning that withstands ethical scrutiny.

Precision and accuracy of quantitative scanning transmission electron microscopy (STEM) methods such as ptychography, and the mapping of electric, magnetic, and strain fields depend on the dose. Reasonable acquisition time requires high beam current and the ability to quantitatively detect both large and minute changes in signal. A new hybrid pixel array detector (PAD), the second-generation Electron Microscope Pixel Array Detector (EMPAD-G2), addresses this challenge by advancing the technology of a previous generation PAD, the EMPAD. The EMPAD-G2 images continuously at a frame-rates up to 10 kHz with a dynamic range that spans from low-noise detection of single electrons to electron beam currents exceeding 180 pA per pixel, even at electron energies of 300 keV. The EMPAD-G2 enables rapid collection of high-quality STEM data that simultaneously contain full diffraction information from unsaturated bright-field disks to usable Kikuchi bands and higher-order Laue zones. Test results from 80 to 300 keV are presented, as are first experimental results demonstrating ptychographic reconstructions, strain and polarization maps. We introduce a new information metric, the maximum usable imaging speed (MUIS), to identify when a detector becomes electron-starved, saturated or its pixel count is mismatched with the beam current.

In order to maximize the utility of future studies of trilobite ontogeny, we propose a set of standard practices that relate to the collection, nomenclature, description, depiction, and interpretation of ontogenetic series inferred from articulated specimens belonging to individual species. In some cases, these suggestions may also apply to ontogenetic studies of other fossilized taxa.

In this article we engage in a critical examination of how local authority Housing Solutions staff, newly placed centre stage in preventing homelessness amongst prison leavers in Wales, understand and go about their work. Drawing on Carlen’s concept of ‘imaginary penalities’ and Ugelvik’s notion of ‘legitimation work’ we suggest practice with this group can be ritualistic and underpinned by a focus on prison leavers’ responsibilities over their rights, and public protection over promoting resettlement. In response we advocate for less-punitive justice and housing policies, underpinned by the right to permanent housing for all prison leavers and wherein stable accommodation is understood as the starting point for resettlement. The analysis presented in this article provides insights to how homelessness policies could play out in jurisdictions where more joint working between housing and criminal justice agencies are being pursued and/or preventative approaches to managing homelessness are being considered.

This study examines the potential health-related impact of recent versus lifetime experiences of sexual orientation discrimination among older Australian lesbian women and gay men. In a nationwide survey, a sample of 243 lesbian women and 513 gay men aged 60 years and over reported on their experiences of sexual orientation discrimination and their mental and physical health, including psychological distress, positive mental health and self-rated health. Among both lesbian women and gay men, recent discrimination uniquely predicted lower positive mental health after adjusting for experiences of discrimination across the lifetime and socio-demographic variables. In addition, recent discrimination uniquely predicted higher psychological distress among gay men. Experiences of discrimination over the lifetime further predicted higher psychological distress and poorer self-rated health among gay men after adjusting for recent experiences of discrimination and socio-demographic variables. However, there were no associations between lifetime discrimination and any of the outcome variables among lesbian women. Overall, recent and lifetime experiences of sexual orientation discrimination were related to mental and physical health in different ways, especially among the men. These findings have potential implications for policy/practice, and suggest that distinguishing between recent and lifetime experiences of discrimination may be useful when assessing potential health-related impacts of sexual orientation discrimination among older lesbian women and gay men, while also taking account of differences between these two groups.

Electron and proton microprobes, along with electron backscatter diffraction (EBSD) analysis were used to study the microstructure of the contemporary Al–Cu–Li alloy AA2099-T8. In electron probe microanalysis, wavelength and energy dispersive X-ray spectrometry were used in parallel with soft X-ray emission spectroscopy (SXES) to characterize the microstructure of AA2099-T8. The electron microprobe was able to identify five unique compositions for constituent intermetallic (IM) particles containing combinations of Al, Cu, Fe, Mn, and Zn. A sixth IM type was found to be rich in Ti and B (suggesting TiB2), and a seventh IM type contained Si. EBSD patterns for the five constituent IM particles containing Al, Cu, Fe, Mn, and Zn indicated that they were isomorphous with four phases in the 2xxx series aluminium alloys including Al6(Fe, Mn), Al13(Fe, Mn)4 (two slightly different compositions), Al37Cu2Fe12 and Al7Cu2Fe. SXES revealed that Li was present in some constituent IM particles. Al SXES mapping revealed an Al-enriched (i.e., Cu, Li-depleted) zone in the grain boundary network. From the EBSD analysis, the kernel average misorientation map showed higher levels of localized misorientation in this region, suggesting greater deformation or stored energy. Proton-induced X-ray emission revealed banding of the TiB2 IM particles and Cu inter-band enrichment.

Three herbicides were compared for their ability to reduce both carbon fixation and soil water depletion by yellow nutsedge in a growth chamber study. Whole-plant CO2 exchange and water use were measured for 11 d after herbicide application. MSMA reduced carbon assimilation relative to the untreated control 1 d after treatment, and by 5 d after treatment respiration exceeded carbon assimilation during the photoperiod; however, MSMA had no significant effect on whole-plant water use during the measurement period. Halosulfuron reduced gross carbon assimilation to 30% of the pretreatment rate by the end of the experiment, but in contrast to MSMA it also strongly suppressed water use. Mesotrione never reduced carbon assimilation below 59% of the pretreatment rate and had no measurable effect on water use. Halosulfuron and MSMA reduced shoot regrowth to between 0 and 5% of the control, whereas mesotrione treatment allowed some 58% regrowth. These results indicate that whereas both MSMA and halosulfuron should provide effective control of yellow nutsedge, halosulfuron may be better able to rapidly suppress the weed's ability to compete for available soil water.

Three models are evaluated for restoring basement rocks coring tectonic windows (Window-Basement) in the Scandinavian Caledonides; parautochthonous (Model I) and allochthonous (models II/III), with initial imbrication of the Window-Basement post-dating or pre-dating, respectively, that in the external imbricate zone (Lower Allochthon). In Model I, the Window-Basement comes from the eastern margin of the basin now imbricated into the Lower Allochthon, while in models II/III it comes from the western margin. In Model II, the Window-Basement formed a basement-high between Tonian and Cryogenian sediments imbricated into the Middle and Lower allochthons; in Model III deposition of the Lower Allochthon sediments commenced in Ediacaran times. Balanced cross-sections and branch-line restorations of four transects (Finnmark–Troms, Västerbotten–Nordland, Jämtland–Trøndelag, Telemark–Møre og Romsdal) show similar restored lengths for the models in two transects and longer restorations for models II/III in the other transects. Model I can result in c. 280 km wide gaps in the restored Lower Allochthon, evidence for which is not seen in the sedimentology. The presence of <3 km thick alluvial-fan deposits at the base of the Middle Allochthon indicates proximal, rapidly uplifting basement during Tonian–Cryogenian periods, taken as the origin of the Window-Basement during thrusting in models II/III. Model I requires multiple changes in thrusting-direction and predicts major thrusts or back-thrusts, currently unrecognized, separating parts of the Lower Allochthon; neither are required in models II/III. Metamorphic data are consistent with models II/III. Despite considerable along-strike structural variability in the external Scandinavian Caledonides, models II/III are preferred for the restoration of the Window-Basement.

Morphometric analyses of silicified and nonsilicified (preserved in shale) specimens of the olenelloid trilobites Olenellus (Olenellus) gilberti Meek (in White, 1874) and Nephrolenellus geniculatus Palmer, 1998, from the Lower Cambrian C-Shale Member of the Pioche Formation show that even well-preserved specimens in shales have undergone significant changes in lateral as well as vertical dimensions as a result of compaction. Analyses of cephalic landmarks show that in both species compaction causes posteriordirected collapse of the anterior lobe of the glabella, adaxial deformation of the ocular lobes, and abaxial and anterior splaying of genal regions. These shape changes are explicable in terms of observed exoskeletal fracture patterns. Landmarks show an increase in scatter around their ontogenetic trajectories that is generally proportional to the degree of lateral shift each landmark has undergone. Interspecific differences in compactional response may depend on the relative convexity of the cephalon. Olenellus (Olenellus) gilberti is a low-convexity species and shows marked lateral shape change, particularly in the genal region. Nephrolenellus geniculatus is more convex and shows less severe lateral shape change. Landmarks of both species exhibit an average trebling of the degree of scatter around their average ontogenetic trajectories in compacted samples. Because even well-preserved specimens in shales differ in shape from their precompactional appearance, results of morphometric studies utilizing metric distances between landmarks in trilobites where compaction can be detected must be interpreted with caution.

We describe a hybrid pixel array detector (electron microscope pixel array detector, or EMPAD) adapted for use in electron microscope applications, especially as a universal detector for scanning transmission electron microscopy. The 128×128 pixel detector consists of a 500 µm thick silicon diode array bump-bonded pixel-by-pixel to an application-specific integrated circuit. The in-pixel circuitry provides a 1,000,000:1 dynamic range within a single frame, allowing the direct electron beam to be imaged while still maintaining single electron sensitivity. A 1.1 kHz framing rate enables rapid data collection and minimizes sample drift distortions while scanning. By capturing the entire unsaturated diffraction pattern in scanning mode, one can simultaneously capture bright field, dark field, and phase contrast information, as well as being able to analyze the full scattering distribution, allowing true center of mass imaging. The scattering is recorded on an absolute scale, so that information such as local sample thickness can be directly determined. This paper describes the detector architecture, data acquisition system, and preliminary results from experiments with 80–200 keV electron beams.

Orchid seeds are among the smallest seeds in nature and they are naturally rich in fatty acids. However, the fatty acid composition of orchid seeds has not been investigated because the sample masses utilized for widely used methods for fatty acid profiling would generally require prohibitively large numbers (i.e. 10,000s) of seeds. The present work aimed to develop a method for fatty acid analysis using gas chromatography–mass spectrometry on small quantities (mg) of seeds. The method was developed using the seeds of two species, Dactylorhiza fuchsii, a temperate terrestrial, and Grammatophyllum speciosum, a tropical epiphyte. A range of sample masses was tested to determine the minimum mass required to achieve reliable fatty acid composition data. A direct transesterification method was used, which did not require extraction of fatty acids from seeds prior to analysis, and the effects of seed processing (crushed versus intact seeds) and incubation time in toluene on fatty acid yield were tested. Stable fatty acid profiles were obtained using as little as 10 mg of seeds. Neither crushing the seeds nor extending the toluene incubation step had much effect on the fatty acid yield. The simple direct transesterification method presented will enable the fatty acid composition of orchid seeds, and possibly other small seeds, to be determined reliably for studies into seed development, storage and germination.

Loneliness is a debilitating condition with particular negative health effects, including psychological distress. While the vast majority of older people do not experience significant degrees of loneliness, a minority do and there are some reports that this is even greater among lesbian, gay, bisexual, transgender and intersex (LGBTI) seniors. This article examines the experience of loneliness and social support among LGBTI people aged 50 and over living in New South Wales, Australia. It also explores their interest in participating in social and health-promoting activities. Findings from an online survey delivered to 312 people are reported. Loneliness was associated with living alone, not being in a relationship, higher psychological distress and lower mental health. Nonetheless, most respondents reported that they are able to gain support from both biological family and friends if they need it in a crisis. The social and health-promoting activities that were most preferred among all respondents were fitness groups, walking groups, swimming and meditation. Those who experienced the greatest degree of loneliness were much more likely than those who were less lonely to want to participate in social and health-promoting activities with other LGBTI people. The findings indicate scope for community organisations to develop targeted interventions, such as those social and health-promoting activities most preferred by the participants of this study.