El objetivo principal de este trabajo es presentar importantes novedades sobre el marco histórico y productivo de la explotación minera de la sierra de Corduba en época romana, así como de la gestión de sus recursos. Desde hace años y a partir de la documentación epigráfica disponible, se ha venido apuntando una posible presencia en este territorio de la societas Sisaponensis y de la explotación de plomo y plata por su parte, a pesar de la afamada vinculación con el beneficio del cinabrio que recoge un conocido pasaje de Plinio. Nuestras investigaciones en el norte de Córdoba y los análisis arqueométricos realizados sobre tres lingotes de plomo recuperados en el paraje de Los Escoriales de Doña Rama, situado en la Sierra de Gata (Belmez-Córdoba), suponen una superación de la frontera del conocimiento sobre los aspectos reseñados, ya que permiten contrastar estas dos hipótesis tradicionales y proponer nuevas cuestiones sobre la explotación de estos parajes y la actividad de esta societas. Estos lingotes fueron encontrados en una instalación minero-metalúrgica romana, algo que es excepcional, y conservan una inscripción, S S, que los vincula sin duda con la societas Sisaponensis.

A checklist of Lichen-forming, Lichenicolous and Allied Fungi of Ecuador is presented with a total of 2599 species, of which 39 are reported for the first time from the country. The names of three species, Hypotrachyna montufariensis, H. subpartita and Sticta hypoglabra, previously not validly published, are validated. Pertusaria oahuensis, originally introduced by Magnusson as ‘ad interim’, is validated as Lepra oahuensis. The form Leucodermia leucomelos f. albociliata is validated. Two new combinations, Fissurina tectigera and F. timida, are made, and Physcia mobergii is introduced as a replacement name for the illegitimate P. lobulata Moberg non (Flörke) Arnold. In an initial step, the checklist was compiled by reviewing literature records of Ecuadorian lichen biota spanning from the late 19th century to the present day. Subsequently, records were added based on vouchers from 56 collections participating in the Consortium of Lichen Herbaria, a Symbiota-based biodiversity platform with particular focus on, but not exclusive to, North and South America. Symbiota provides sophisticated tools to manage biodiversity data, such as occurrence records, a taxonomic thesaurus, and checklists. The thesaurus keeps track of frequently changing names, distinguishing taxa currently accepted from ones considered synonyms. The software also provides tools to create and manage checklists, with an emphasis on selecting vouchers based on occurrence records that can be verified for identification accuracy. Advantages and limitations of creating checklists in Symbiota versus traditional ways of compiling these lists are discussed. Traditional checklists are well suited to document current knowledge as a ‘snapshot in time’. They are important baselines, frequently used by ecologists and conservation scientists as an established naming convention for citing species reported from a country. Compiling these lists, however, requires an immense effort, only to inadequately address the dynamic nature of scientific discovery. Traditional checklists are thus quickly out of date, particularly in groups with rapidly changing taxonomy, such as lichenized fungi. Especially in megadiverse countries, where new species and new occurrences continue to be discovered, traditional checklists are not easily updated; these lists necessarily fall short of efficiently managing immense data sets, and they rely primarily on secondary evidence (i.e. literature records rather than specimens). Ideally, best practices make use of dynamic database platforms such as Symbiota to assess occurrence records based both on literature citations and voucher specimens. Using modern data management tools comes with a learning curve. Systems like Symbiota are not necessarily intuitive and their functionality can still be improved, especially when handling literature records. However, online biodiversity data platforms have much potential in more efficiently managing and assessing large biodiversity data sets, particularly when investigating the lichen biota of megadiverse countries such as Ecuador.

The Monitoring Studies (MS) program, the approach developed by RedETS to generate postlaunch real-world evidence (RWE), is intended to complement and enhance the conventional health technology assessment process to support health policy decision making in Spain, besides informing other interested stakeholders, including clinicians and patients. The MS program is focused on specific uncertainties about the real effect, safety, costs, and routine use of new and insufficiently assessed relevant medical devices carefully selected to ensure the value of the additional research needed, by means of structured, controlled, participative, and transparent procedures. However, despite a clear political commitment and economic support from national and regional health authorities, several difficulties were identified along the development and implementation of the first wave of MS, delaying its execution and final reporting. Resolution of these difficulties at the regional and national levels and a greater collaborative impulse in the European Union, given the availability of an appropriate methodological framework already provided by EUnetHTA, might provide a faster and more efficient comparative RWE of improved quality and reliability at the national and international levels.

Pulses such as peas, beans or lentils are one of the most complete foods at the nutritional level; however, they are one of the most often neglected foods in the diets of university students. Entrance to university translates into a major lifestyle change for many young people, and the habits acquired or cemented at this time will remain into adulthood. The objective of this study is to analyse the association between personal/sociodemographic factors, dietary intake of other food groups and the consumption of pulses in first-year university students. This cross-sectional study is part of the UniHcos project, a multicentre study of multipurpose prospective cohorts in eleven Spanish universities. Data from 9862 university students were collected through an online self-questionnaire completed by all students who met the selection criteria and agreed to participate in the project during the 2011–2018 academic years. Of students, 75·8 % presented an inadequate (≤2 times/week) consumption of pulses. Living outside the family home in either a student residence (OR 0·76; 95 % CI 0·69, 0·84) or rental (OR 0·81; 95 % CI 0·70, 0·95) decreased the compliance with recommendations on the consumption of pulses. Low consumption of pulses is seemingly not restricted to a specific profile or dietary pattern among university students, and no specific focus group for intervention can be identified. Policies promoting the consumption of pulses among the university population as a whole are necessary to increase compliance rates with the dietary recommendations.

The multipurpose plant Moringa oleifera (MO) has shown a variety of in vitro activities potentially beneficial for health and evidences are also numerous in animal models. However, the exact composition of the plant is highly variable depending on the area, culture and post harvesting conditions and the effects in humans are scarcely studied. This is a pilot study of the effect of different doses of MO from an Iberian Peninsula cultivar on postprandial glucose level in non-diabetic subjects. Five adult subjects (40 to 70 years, 3 males) with normal renal and hepatic function were included. Two had normal fasting glucose and 3 had pre-diabetic fasting glucose. A standard breakfast plus, respectively, one placebo capsule (PLC), or 1, 3 and 6 capsules containing 400 mg of MO dry leaf powder (MO-1cap, -3cap and -6cap) were consumed by each subject on 4 consecutive visits, one week apart. The basal and postprandial (30, 60, 90, 120, 150 and 180 min) glucose was measured. The mean glucose change from baseline (ΔGlc) at each measure time was calculated and compared between treatments with the Wilcoxon tests and considered significant at P < 0.05 level. The postprandial curves were also studied separately in pre-diabetic subjects. A difference was found 90 min after breakfast in ΔGlc for the MO-6cap compared to the MO-1cap, being lower in MO-6cap. No more significant differences were observed due to the small number of subjects and high variability in glucose values among subjects. However, the graphical representation of separated curves for the three pre-diabetic participants showed that all three MO doses led to values always below those with PLC. In addition, during the first experimental hour all MO doses showed lower ΔGlc than PLC while this was not the case when all subjects were studied. No adverse events occurred during the experiment. The study, thus, showed a trend to lower glycemic postprandial response with MO leaf powder which seems to be more evident in pre-diabetic subjects than in normoglycemic subjects and especially during the first postprandial hour. The MO-6cap seems to be the election daily dose for a long term intervention study on the glycemic control with MO in pre-diabetic subjects.

A low cost robotic-assisted prototype for finger and hand rehabilitation of people affected by a stroke is presented. The system was developed by a team of undergraduate students led by a Design lecturer in collaboration with the Rehabilitation Unit of the Peñablanca Public Hospital in Chile.

The system consists of a flexion sensor equipped glove, a hand exoskeleton and an Arduino control unit. The patient wears the glove in his healthy hand. When s/he performs movements with the healthy hand, the sensors register the flexion of the fingers and send this information to the servo motors installed in an exoskeleton attached to the affected hand. In this way, the affected hand reproduces the movement of the healthy hand. The system uses a combination of the mirror therapy (the patient sees his/her affected hand moving in the same way that the healthy hand does) and passive exercising (as the exoskeleton produces the movement of the hand affected by the stroke). The combination of two types of therapy in a single low cost system makes the present work unique. In the near future, the developed prototype will be used to validate the effectiveness of the new proposed robotic therapy.

Earlier activities on health technology assessment (HTA) started in Spain around 1984, with the creation of a National Advisory Board on HTA, and the development of national and regional HTA organizations in the early 1990s. In 2012, the Spanish Health Ministry established the Spanish Network for Health Technology Assessment of the National Health System (RedETS); funded at national level and including all public HTA organizations at national and regional levels. RedETSis focused on the assessment of nondrug health technologies to inform the revision (approval and funding or disinvestment) of the Benefit Portfolio of the Spanish NHS. In parallel with European Network for Health Technology Assessment (EUnetHTA), RedETS has been setting-up and sharing common procedures and methodological guidelines to ensure effective cooperation and mutual recognition of the scientific and technical production in HTA. The output of RedETS is fifty to sixty annual reports, including the production of full HTA reports, Clinical Practice Guidelines, methodological guidance reports, relative effectiveness assessments, tools to support shared decision making between patients and healthcare professionals, and monitoring studies. The HTA assessments requested by the Regional Health Authorities are the biggest component of the annual RedETS working plan. These assessment needs are identified according to a yearly process and prioritized by a Commission composed of representatives from all Spanish regions with the aid of the PRITEC tool. The objectives of this study are to report and update the normative and organizational state of HTA in Spain; describing noteworthy advances witnessed over the past 10 years, as well as discussing existing challenges.

This study aimed to evaluate the associations between the muscle mass to visceral fat (MVF) ratio and cardiometabolic risk factors in a large population of college students in Colombia and to propose cut-off points of this index for the metabolic syndrome (MetS). A total of 1464 young adults recruited from the FUPRECOL (Asociación de la Fuerza Prensil con Manifestaciones Tempranas de Riesgo Cardiovascular en Jóvenes y Adultos Colombianos) study were categorised into four groups based on their MVF ratio. Muscle mass and visceral fat level of the participants were measured using a bioelectrical impedance analysis. Cardiometabolic risk factors including lifestyle characteristics, anthropometry, blood pressure and biochemical parameters were assessed. The prevalence of moderate to severe obesity, hypertension and the MetS was higher in subjects in quartile (Q)1 (lower MVF ratio) (P <0·001). ANCOVA revealed that the subjects in Q1 had higher cardiometabolic disturbances, including altered anthropometry, blood pressure, muscle strength and biochemical parameters after adjusting for age and sex compared with young adults in higher MVF ratio quartiles (P <0·001). Muscular mass and physical activity levels were significantly lower in subjects with a lower MVF ratio (P <0·001). The receiver operating characteristic curve analyses indicated that in men the best MVF ratio cut-off point for detecting the MetS was 18·0 (AUC 0·83, sensitivity 78 % and specificity 77 %) and for women, the MVF ratio cut-off point was 13·7 (AUC 0·85, sensitivity 76 % and specificity 87 %). A lower MVF ratio is associated with a higher risk cardiometabolic profile in early adulthood, supporting that the MVF ratio could be used as a complementary screening tool that may help clinicians identify young adults at high cardiometabolic risk.

This is the first part of an ongoing taxonomic treatment of Bunodophoron (Sphaerophoraceae, Lecanorales) in the Neotropics, based on the molecular phylogenetic analysis of three markers together with studies of morphology and chemistry, and using the general mixed Yule coalescence (GMYC) method to delimit species boundaries. In the Neotropics, species in this genus grow on the ground or on shrubs in the páramos, and as epiphytes in the montane rainforests. We describe here a new species from the páramos of Colombia, Bunodophoron crespoae Soto, M. Prieto & Wedin sp. nov., and discuss its distinction from another large and common páramo species Bunodophoron flabellatum (Hue) Soto, M. Prieto & Wedin comb. nov. Both species are primarily terrestrial in the páramos, although B. flabellatum may occasionally also grow as an epiphyte. Bunodophoron crespoae is characterized by the white, c. 10–13 cm long, subterete to narrowly flattened, main branches. It differs from the otherwise similar B. flabellatum by being distinctly subterete, more abundantly branched, and by having smaller ascospores. Both are distinguished from the primarily epiphytic B. melanocarpum by the considerably larger thallus size, with the main branches of B. melanocarpum rarely exceeding 3·5 cm in length and 2 mm in width.

The distribution of the sum of dependent risks is a crucial aspect in actuarial sciences, risk management and in many branches of applied probability. In this paper, we obtain analytic expressions for the probability density function (pdf) and the cumulative distribution function (cdf) of aggregated risks, modelled according to a mixture of exponential distributions. We first review the properties of the multivariate mixture of exponential distributions, to then obtain the analytical formulation for the pdf and the cdf for the aggregated distribution. We study in detail some specific families with Pareto (Sarabia et al., 2016), gamma, Weibull and inverse Gaussian mixture of exponentials (Whitmore and Lee, 1991) claims. We also discuss briefly the computation of risk measures, formulas for the ruin probability (Albrecher et al., 2011) and the collective risk model. An extension of the basic model based on mixtures of gamma distributions is proposed, which is one of the suggested directions for future research.

The cyanolichen genus Epiphloea is currently included within the Heppiaceae (Lichinomycetes) based on ascus characteristics. The presumed presence of a prototunicate ascus has been used as support for this classification, despite the incongruence with other characters (e.g. spores). Here, we use a molecular phylogeny of the two markers mtSSU rDNA and Mcm7 to investigate the position of Epiphloea. In addition, we have re-investigated the ascus characteristics. Our results place the two species, Epiphloea byssina and E. terrena, within the Collemataceae, nested in Leptogium s. str. The ascus type in both species is shown to be Lecanoralean and similar to the ascus in other Collemataceae, with a strongly amyloid tube-like structure. This observation supports the placement within Lecanoromycetes and refutes the earlier suggested affinities with Heppiaceae and Lichinomycetes. The correct names for these species are Leptogium byssinum and Leptogium terrenum.

Lobarina scrobiculata (better known as Lobaria scrobiculata) is a widespread lichen, threatened and Red-Listed in various European countries. Microsatellite markers for the mycobiont of L. scrobiculata were developed in order to investigate its genetic diversity in the Iberian Peninsula and Europe and to design effective conservation strategies. A total of 7 polymorphic markers were isolated and characterized. These microsatellites were tested in natural populations found in the Iberian Peninsula. The number of observed alleles ranged from 3 to 8, and the Nei's unbiased gene diversity from 0·26 to 0·59. These microsatellite markers are the first to be developed for L. scrobiculata and they will be useful for population studies and for the assessment of the conservation status of this species.

One of the unresolved issues in the field of intonational phonology is whether pitch accent range differences are used by languages to express discrete linguistic distinctions. In Catalan, as in some other Romance languages, a rising-falling nuclear pitch contour – i.e. a rising pitch accent associated with the utterance-final stressed syllable followed by a Low boundary tone – can be used to convey three different pragmatic meanings depending on its pitch range properties: information focus statements (IFSs), corrective focus statements (CFSs), and counter-expectational questions (CEQs). In order to investigate how these pragmatic meanings are distributed across the pitch range continuum and whether Catalan listeners use these tonal scaling distinctions to identify such meanings, we performed an identification task and a congruity test. The results show that CEQs differ from both IFSs and CFSs in a discrete way, yet the perceived difference between IFSs and CFSs cannot be exclusively explained by scaling differences. These findings provide further evidence that pitch range differences can be used to make intonational distinctions in some languages, and strengthen the argument that pitch range features need to be represented descriptively at the phonological level.