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We are revisiting the topic of travelling fronts for the food-limited (FL) model with spatio-temporal nonlocal reaction. These solutions are crucial for understanding the whole model dynamics. Firstly, we prove the existence of monotone wavefronts. In difference with all previous results formulated in terms of ‘sufficiently small parameters’, our existence theorem indicates a reasonably broad and explicit range of the model key parameters allowing the existence of monotone waves. Secondly, numerical simulations realized on the base of our analysis show appearance of non-oscillating and non-monotone travelling fronts in the FL model. These waves were never observed before. Finally, invoking a new approach developed recently by Solar et al., we prove the uniqueness (for a fixed propagation speed, up to translation) of each monotone front.
Circulating cell-free DNA (cfDNA) consists of small fragments of DNA that circulate freely in the bloodstream. In cancer patients, a fraction of cfDNA is derived from tumour cells, therefore containing the same genetic and epigenetic alterations, and is termed circulating cell-free tumour DNA. The potential use of cfDNA, the so-called ‘liquid biopsy’, as a non-invasive cancer biomarker has recently received a lot of attention. The present review will focus on studies concerning the potential clinical applications of cfDNA in ovarian cancer patients.
Cognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have a deleterious effect on cognitive performance remains under debate. We aim to investigate whether anticholinergic loadings and dose of AP drugs in first episode of psychosis (FEP) in advanced phase of remission are associated with cognitive impairment and the differences between premorbid intellectual quotient (IQ) subgroups.
Two hundred and sixty-six patients participated. The primary outcomes were cognitive dimensions, dopaminergic/anticholinergic load of AP [in chlorpromazine equivalents (Eq-CPZ) and the Anticholinergic Risk Scale (ARS), respectively].
Impairments in processing speed, verbal memory and global cognition were significantly associated with high Eq-CPZ and verbal impairment with high ARS score. Moreover, this effect was higher in the low IQ subgroup.
Clinicians should be aware of the potential cognitive impairment associated with AP in advanced remission FEP, particularly in lower premorbid IQ patients.
This paper is focused on explaining the radiation test in temperature performed on the Engineering and Qualification Model of the Medium Gain Antenna Radiofrequency (MGA-RFA) Assembly of ESA's BepiColombo mission. The goal of this program is to observe and study Mercury and its surroundings in a very demanding environment in terms of temperature and radiation. The MGA is an X-band two-axis steerable horn, which provides bidirectional communications between spacecraft and Earth as backup of the High Gain Antenna and also operates as primary communication link at several mission stages or conditions. The paper presents the measurement set-up for the qualification campaign of the antenna, where it was necessary to characterize the antenna in a representative thermal environment, and the results obtained from this test. Results of test up to 150°C show how gain and radiation pattern shapes are slightly affected by thermal stress, but without jeopardizing mission requirements. In addition, by analyzing correlation of this test with RF analysis in the same thermal conditions, it becomes possible to accurately extrapolate the MGA-RFA behavior up to temperatures of more than 500°C. This fact allowed the successful space qualification of this model.
This article offers a critical analysis of scholarship produced about Brazil's Banco Nacional de Desenvolvimento Econômico e Social (BNDES) since its founding, in 1952, to 2013. BNDES has performed an important, if changing and sometimes controversial, role in Brazil's economic development over the past 60 years, especially as provider of long-term finance. This analysis of almost 1,000 texts highlights discussions about its initial organisation and mission and how the role and activities of the bank changed over time, guided by turbulent national political and economic contexts. In spite of the bank's institutional importance, however, the literature is more narrative than analytical and of limited scholarly impact, dominated as it is by the bank's authorship. We argue for independent, evidence-driven, critical analyses of the effectiveness of this important institution in promoting Brazil's economic and social development.
Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated measurements of dietary changes during follow-up. Moreover, previous studies included healthy and selected participants who did not represent subjects at high cardiovascular risk. We used yearly repeated measurements of diet to investigate the association between fibre intake and CVD in a Mediterranean cohort of elderly adults at high cardiovascular risk. We followed-up 7216 men (55–80 years) and women (60–80 years) initially free of CVD for up to 7 years in the PREvención con DIeta MEDiterránea study (registered as ISRCTN35739639). A 137-item validated FFQ was repeated yearly to assess diet. The primary end point, confirmed by a blinded ad hoc Event Adjudication Committee, was a composite of cardiovascular death, myocardial infarction and stroke. Time-dependent Cox’s regression models were used to estimate the risk of CVD according to baseline dietary exposures and to their yearly updated changes. We found a significant inverse association for fibre (Pfor trend=0·020) and fruits (Pfor trend=0·024) in age-sex adjusted models, but the statistical significance was lost in fully adjusted models. However, we found a significant inverse association with CVD incidence for the sum of fruit and vegetable consumption. Participants who consumed in total nine or more servings/d of fruits plus vegetables had a hazard ratio 0·60 (95 % CI 0·40, 0·96) of CVD in comparison with those consuming <5 servings/d.
Workers’ perception that their job experience enriches their family life has been considered a mechanism that explains their positive attitudes toward the organization where they work. However, because women and men live their work and family differently, gender may condition this relationship between the work-family enrichment and workers’ attitudes. With a sample of 1885 workers from one Portuguese bank, with 802 women, the current study investigated the relationship between work-family enrichment and organizational affective commitment as well as the role of sex as a moderator of this relationship. The hypotheses were tested by using regression analysis. The results indicated that the perception held by workers that their work enriches their family is positively correlated with their affective commitment toward the organization. Furthermore, the data revealed that this relationship is stronger for women than for men. Study results have implications for management, particularly for human resource management, enhancing their knowledge about the relationship of work-family enrichment and workers’ affective commitment toward organization.
Objectives: This publication aims to report the cases of four children with pseudoaneurysm of the mitral-aortic intervalvular fibrosa and carry out a review of the literature. Background: Pseudoaneurysm of the mitral-aortic intervalvular fibrosa is a very rare anomaly in children. It can be either congenital or acquired, namely, after bacterial endocarditis or cardiac trauma. This pathology does not usually cause specific symptoms but its outcome may be potentially fatal. Methods: We report the cases of four patients presenting with pseudoaneurysm of the mitral-aortic intervalvular fibrosa, referred for treatment in a paediatric cardiology clinic. Patient clinical notes were retrospectively reviewed for aetiology, clinical presentation, diagnostic work-up, surgical treatment, and follow-up. Literature on the subject was extensively reviewed. Results: In three patients, pseudoaneurysm of the mitral-aortic intervalvular fibrosa was acquired, being secondary to bacterial endocarditis in two cases and establishing after mitral surgery in another case. The remaining patient had a “congenital” aetiology – no other cause could be traced. The diagnosis was achieved by transthoracic echocardiography for all patients, and confirmed in all by trans-oesophageal echocardiography, to better define morphological details and to access flow into the aneurysmal formation. All patients were submitted to corrective cardiac surgery. Of the patients, three survived and were cured by surgery, staying asymptomatic, and one died after repeated interventions, for persistent endocarditis. Conclusions: Pseudoaneurysm of the mitral-aortic intervalvular fibrosa is a rare but potentially fatal anomaly. In our experience, surgical cure was achieved for the majority of the cases, except for a case for which infection could not be locally eradicated, leading to multiple reinterventions.
The solutions of a perturbed linear ordinary differential equation (ODE) system are studied. Provided that some integrability and oddness conditions are satisfied, we show that they are asymptotically equivalent at t = ±∞ to the solutions of the unperturbed one. This fact is used to determine the existence of almost periodic or pseudo-almost periodic solutions of the perturbed system.
To investigate the association between Helicobacter pylori infection and anaemia.
Six cross-sectional studies. H. pylori infection was assessed by the [13C]urea breath test using MS or IR analysis. Hb was measured for all countries. Ferritin and transferrin receptors were measured for Argentina, Bolivia, Mexico, and Venezuela.
Health services in Argentina, Brazil and Mexico or public schools in Bolivia, Cuba and Venezuela.
In Argentina, 307 children aged 4–17 years referred to a gastroenterology unit; in Bolivia, 424 randomly selected schoolchildren aged 5–8 years; in Brazil, 1007 adults (157 men, 850 women) aged 18–45 years attending thirty-one primary health-care units; in Cuba, 996 randomly selected schoolchildren aged 6–14 years; in Mexico, seventy-one pregnant women in their first trimester attending public health clinics; in Venezuela, 418 children aged 4–13 years attending public schools.
The lowest prevalence of H. pylori found was among children in Argentina (25·1 %) and the highest in Bolivia (74·0 %). In Bolivia, Cuba and Venezuela children showed similar prevalence of H. pylori infection as in Brazilian and Mexican adults (range 47·5 % to 81·8 %). Overall anaemia prevalence was 11·3 % in Argentina, 15·4 % in Bolivia, 20·6 % in Brazil, 10·5 % in Cuba and 8·9 % in Venezuela. Adjusted analyses allowing for confounding variables showed no association between H. pylori colonization and anaemia in any study. Hb, ferritin and transferrin receptor levels were also not associated with H. pylori infection in any country.
The present study showed no evidence to support the hypothesis that H. pylori contributes to anaemia in children, adolescents, adults or pregnant women in six Latin American countries.
We have recently had the opportunity of studying a plague epidemic that broke out on Terceira Island, Azores, in 1908. Terceira Island contains a population of 45,000 souls, the epidemic spread over 27 parishes. About 260 persons were attacked, with a mortality of about 48%.
We study the stability of periodic solutions of the scalar delay differential equation
where f(t) is a periodic forcing term and δ,p∈R. We study stability in the first approximation showing that the non-smooth equation (*) can be linearized along some ‘non-singular’ periodic solutions. Then the corresponding variational equation together with the Krasnosel'skij index are used to prove the existence of multiple periodic solutions to (*). Finally, we apply a generalization of Halanay's inequality to establish conditions for global attractivity in equations with maxima.
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