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2 results

  • Chapter 29 - Assisted hatching
  • from Section 5 - Laboratory
  • Edited by Gab Kovacs, Monash University, Victoria
  • Book: How to Improve your ART Success Rates
  • Published online: 05 July 2011
  • Print publication: 30 June 2011, pp 156-160
  • View extract

    Summary

    Hardening of the zona pellucida is thought to be influenced by suboptimal culture of embryos in vitro, advancing age in vivo, duration of hormonal stimulation during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), and smoking. There is some evidence that embryos that have undergone zona manipulation for assisted hatching (AH) tend to implant one day earlier than unhatched embryos. The author's group conducted a Cochrane review in 2003 which was updated in 2007 to determine whether AH of embryos following assisted conception improved live birth and clinical pregnancy rates. The primary outcome measure was live birth rate per woman randomized, as this reflects the take home baby rate that is crucial to any assisted reproduction technology (ART). Significant improvement in clinical pregnancy rate was seen independent of the degree of AH, be it thinning, drilling a small hole in the zona or complete zona removal.