Flexible substrates, like plastic, paper and cotton fabrics can be of interest for several reasons in connection to the appealing issue of generating voltage-current from piezoelectric ZnO nanowires (NWs). Zinc oxide NWs have shown very high voltage generation and they are possible to grown on plastic, paper and cotton. Since we with these substrates can get a new freedom to bend and also stretch the NWs and to incorporate them into new applications they are of great potential. Here we will describe the mechanical and piezoelectric properties of ZnO NWs grown on ordinary clean room paper and on cotton fabrics substrates as well as possibility of coating the ZnO NWs to maximize the output generated power. An enhancement of 160 times in the piezo-potential was observed from ZnO NWs coated with P3HT p-type polymer compared to non-coated NWs.