People with serious mental illness exhibit higher morbidity and mortality rates of chronic diseases than the general population.

The aim of this study was to establish a dedicated clinic for patients with chronic mental illness to monitor physical health in accordance with best practice guidelines.

Patients were invited to attend the metabolic clinic. The following areas were examined: Personal and family history of cardiovascular disease, diet, exercise, smoking. Mental state examination, waist circumference, BP, pulse, ECG and BMI. Laboratory tests including U+E, LFTs, HbA1c, Lipid profile and other tests as appropriate such as serum lithium. AIMS scale, HoNOS and WHOQOL-BREF scales as additional indicators of global health.

A total of 80 patients attended during 3.5 years of clinic. Mean age was 54.9 years (SD:13.81) at first contact and 45% were females. Mean years in the service was 19.66 (SD:11.54) and mean number of previous hospital admissions was 4.4 (SD:5.63). Metabolic syndrome was present in 42% at first assessment and 20% had at least one new physical abnormality identified during the clinic. A statistically significant difference was found for the psychological domain of the WHOQOL-BREF and the HoNOs particularly at third assessment. (β=4.64, Wald x2=7.38, df:1, p=0.007, CI:1.3-8.1, β =-.889, Wald x2=4.08, df:1, p=0.043, CI: -1.752 to-.026) respectively.

The results show a high prevalence of physical health conditions in this cohort, some of which represent a new diagnosis. This implicates better allocation of existing resources for screening and early detection, and potential to run joint clinics with primary care.

No significant relationships.

Depression is characterized by a pattern of specific changes in the network organization of brain functioning.

We researched a graph structure specificity in a depressive student sample by analyzing resting-state EEG. All possible combinations of graph metrics, frequency bands, and sensors/sources levels of networks were examined.

We recorded resting-state EEG in fourteen participants with high Beck Depression Inventory score (24.4 ± 9.7; 20.4 ± 1.5 y.o.; 14 females; 1 left-handed) and fourteen participants with a low score (6.8 ± 3.7; 21.3 ± 2.0 y.o.; 8 females; 1 left-handed). We applied weighted phase-lag index (wPLI) to construct functional networks at sensors and sources levels and computed characteristic path length (CPL), clustering coefficient (CC), index of modularity (Q), small-world index (SWI) in 4-8, 8-13, 13-30, and 4-30 Hz frequency bands. We used Mann-Whitney U-test (p < 0.05) to investigate between-group differences in the graph metrics.

The depressive sample was characterized by increased CC and Q in the 4-30 Hz band networks and decreased CPL in the beta-band network (sensors-level for CPL and CC, and sources-level for Q).

Elevated CC and Q may relate to an increase of intramodular connectivity, and CPL reduction reflects the global connectivity increasing. We hypothesize that intramodular hyperconnectivity could explain the rise of global functional connectivity in participants with depressive symptoms. Funding: This research has been supported by the Interdisciplinary Scientific and Educational School of Lomonosov Moscow State University ‘Brain, Cognitive Systems, Artificial Intelligence’.

No significant relationships.

Recent studies mostly focus on the links between measures of alpha-band EEG networks and intelligence. However, associations between wide frequency range EEG networks and general intelligence level remain underresearched.

In this study in a student sample we aimed to correlate the intelligence level and graph metrics of the sensors/sources-level networks constructed in different frequency EEG bands.

We recorded eyes-closed resting-state EEG in 28 healthy participants (21.4±2.1 y.o., 18 females, 1 left-handed). The Raven’s Standard Progressive Matrices Plus (‘SPM Plus’, 60 figures) was used as an intelligence measure. We constructed networks for all possible combinations of sensors/sources-level and 4-8, 8-13, 13-30, or 4-30 Hz frequency bands using Weighted Phase-Lag Index (wPLI), and calculated four graph metrics (Characteristic Path Length, Clustering Coefficient, Modularity, and Small World Index) for each network. Spearman correlation (with Holm-Sidak correction) was applied to characterize the relations between the SPM Plus scores and all the network metrics.

SPM Plus scores varied from 35 to 57 (mean 45.3±4.2), and the intelligence level negatively correlated with Modularity in beta-band (r = -0.63, pcorr = 0.0253).

High modularity may reflect relatively high segregation, but not integration, of networks (Girn, Mills, Christoff, 2019). Accordingly, our findings may shed light on the neural mechanisms of the general inefficiency of global cognitive processing in the case of intellectual decline related to different mental disorders. Funding: This research has been supported by the Interdisciplinary Scientific and Educational School of Lomonosov Moscow State University ‘Brain, Cognitive Systems, Artificial Intelligence’.

No significant relationships.

Frontal sinus obliteration is often performed using fat, autologous bone or a range of synthetic materials. This paper reports the long-term clinical and radiological outcomes of frontal sinus obliteration using beta-tricalcium phosphate putty.

A retrospective audit was performed of patients who underwent frontal sinus obliteration with beta-tricalcium phosphate putty. Patient-, disease- and procedure-related data were collected. Pre- and post-operative computed tomography scans were reviewed to assess bone integration.

Four patients underwent frontal sinus obliteration using beta-tricalcium phosphate putty for treatment of a cerebrospinal leak, mucocele and recalcitrant frontal sinusitis. All patients had disease resolution, with no intra- or post-operative complications reported in the 16.5-month follow up. Post-operative computed tomography scans confirmed native bone obliteration of the frontonasal ducts in all patients.

Beta-tricalcium phosphate putty is a safe and effective option for bone obliteration of the frontal sinus in a range of pathologies, including cerebrospinal fluid leak.

The process of identifying and connecting with clinical trial study teams can be challenging and difficult for members of the public. The national volunteer community registry, ResearchMatch, and the public clinical trials search tool, Trials Today, work in tandem to bridge this connection by providing a streamlined process for potential participants to identify clinical trials which may be of interest.

Building on the existing infrastructure of ResearchMatch and Trials Today, we created a mechanism by which the public can request that their basic contact information (e.g., email/phone) be securely shared with any actively recruiting clinical trial, including trials with no existing relationship with ResearchMatch.

Within the first 2 years of use (July 2019–July 2021), ResearchMatch Volunteers sent 12,251 requests to study teams. On average, 20% of these requests were accepted by the study teams.

The utilization of this tool indicates that there is active interest among members of the public to independently contact study teams about trials of interest. Additionally, research teams unaffiliated with ResearchMatch are willing to at minimum accept contact information. This allows ResearchMatch to successfully serve as a medium, connecting members of the public with actively recruiting trials.

To determine histopathological changes in nasal mucosa associated with duration of nasal packing with Merocel tampons.

This study included 24 healthy rabbits, 6 rabbits per group. In group A, no tampon was applied. In group B, Merocel nasal tampons were applied and removed after 24 hours. In group C, the tampons were removed after 48 hours. In group D, the tampons were removed after 5 days. Specimens were obtained from the septum of each rabbit, including cartilage. Histopathological examination was performed.

Significant differences were observed in terms of inflammatory infiltration and loss of cilia between groups A and B. Significant differences were also observed in terms of inflammatory infiltration, haematoma, cilia loss, epithelium dysplasia and cartilage degeneration between groups B and C. There were significant differences in terms of cilia loss, epithelium dysplasia and subepithelial fibrosis between groups C and D. Cartilage degeneration was mild in one animal in group B and in two animals in group C, and was moderate in four animals in group C.

It is recommended that Merocel nasal tampons are removed within 48 hours to preserve nasal mucosal function. Keeping the pack longer may cause cartilage degeneration and other complications.

To assess current demographics and duties of physicians as well as the structure of paediatric cardiac critical care in the United States.

REDCap surveys were sent by email from May till August 2019 to medical directors (“directors”) of critical care units at the 120 United States centres submitting data to the Society of Thoracic Surgeons Congenital Heart Surgery Database and to associated faculty from centres that provided email lists. Faculty and directors were asked about personal attributes and clinical duties. Directors were additionally asked about unit structure.

Responses were received from 66% (79/120) of directors and 62% (294/477) of contacted faculty. Seventy-six percent of directors and 54% of faculty were male, however, faculty <40 years old were predominantly women. The majority of both groups were white. Median bed count (n = 20) was similar in ICUs and multi-disciplinary paediatric ICUs. The median service expectation for one clinical full-time equivalent was 14 weeks of clinical service (interquartile range 12, 16), with the majority of programmes (86%) providing in-house attending night coverage. Work hours were high during service and non-service weeks with both directors (37%) and faculty (45%).

Racial and ethnic diversity is markedly deficient in the paediatric cardiac critical care workforce. Although the majority of faculty are male, females make up the majority of the workforce younger than 40 years old. Work hours across all age groups and unit types are high both on- and off-service, with most units providing attending in-house night coverage.

Throughout the COVID-19 pandemic, older adults have been disproportionately impacted by both illness and fatalities. Of the nearly 39 million adults over age 65 in the United States, approximately 2.4 million older adults identify as lesbian, gay, bisexual, transgender, or queer (LGBTQ). LGBTQ older adults face unique challenges due to their intersecting identities and histories, including the effects of heterosexism, ageism, and being more likely to live alone, be single, and not have children. As we implement social distancing as a primary COVID-19 prevention method, older adults have faced increased isolation.

We presented a case of a lesbian older adult patient who has experienced increased depression during the COVID-19 pandemic. A table will be added featuring culturally competent recommendations for LGBTQ older adults from a literature review.

A 77-year-old female with history of major depression, attention deficit disorder, hypertension, xerostomia, and polymyalgia rheumatica. The patient has been on multiple trials of medications for depression as well as ECT treatments. She was initially engaged to a man and after some years fell in love with a woman. The patient is currently single and has no children. She typically has a strong support system with her lifelong friend and attends church. She transitioned from independent living to an adult living facility, with the hope of increased social activity and connectedness. However, due to COVID-19, she experienced her move as extremely difficult, and was disappointed that all social activities were canceled. For a period of several months, she was unable to visit her chosen family, was limited to attending church via Zoom, and was restricted from multiple areas of the complex. As a result, she reported increased depression, anxiety, and difficulty sleeping with passive suicidal ideation due to isolation and no direct family support.

Older LGBTQ populations are at disproportionately higher risk for mental health conditions and with the current social distancing measures in place, social isolation and loneliness has been exacerbated.

Connection with accepting family and community are well documented in the literature as key protective factors and sources of resiliency in LGBTQ populations. Culturally competent care is integral to psychiatric treatment of older LGBTQ adults.

This abstract was presented at the American Association of Geriatric Psychiatry 2021 Annual Meeting.