On scales ranging from pcs to kpcs, the relationship between stellar and gaseous galactic components forms the basis for interpreting observations of galaxies and understanding galaxy formation and evolution. Feedback effects from massive stars dominate the structure, ionization, kinematics, and enrichment of the gaseous ISM in star-forming galaxies. On galactic scales, the ionizing radiation from these stars creates populations of H II regions and the diffuse, warm ionized medium. Likewise, superbubbles created by stellar winds and supernovae strongly influence the structure, kinematics, and balance of the multiphase ISM. This contribution reviews these feedback effects of massive stars on the global ISM.