Genetic manipulation of leaf architecture may be a useful breeding objective in cotton (Gossypium spp.). The present study reports quantitative genetic analysis of leaf traits from two intraspecific crosses of inbred lines in upland cotton (Gossypium hirsutum L.) viz. Kang3×Chaoji463 and Han109×Ji98. Six leaf morphological traits (leaf area (LA), leaf perimeter (LP), main lobe length (LL) and width (LW), petiole length (PL), and main LL/LW ratio) were recorded from multiple generations (P1, F1, P2, BC1, BC2, and F2) in the two crosses. Generation mean analyses were conducted to explain the inheritance of each leaf morphological trait. The six-parameter model showed a better fit to an additive-dominance model for LA, main LW, PL, and main LL/LW ratio in the two crosses, suggesting the relative importance of epistatic effects controlling leaf morphology. A simple additive-dominance model accounted for the genetic variation of the main LL in the Kang3×Chaoji463 cross. Different models were selected as appropriate to explain LP in the two crosses. The differences between broad- and narrow-sense heritability values for the same trait were not constant in the two crosses. The estimated minimum number of genes controlling each leaf morphological trait ranged from 0 to 2 for both the crosses. Moreover, the sums of the minimum number of genes controlling leaf morphology were 6 and 2 in the Kang3×Chaoji463 and Han109×Ji98 populations, respectively. Most data suggested that there existed a substantial opportunity to breed cottons that transgress the present range of leaf phenotypes found.