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This study gives details of a rare case of petrous apicitis that presented as Gradenigo's syndrome and was managed surgically.
This study presents a case report and review of the literature.
A four-year-old female was admitted for failure to thrive following recent sinusitis. Physical examination was positive for right sided facial pain, photophobia and right abducens nerve palsy. Subsequent magnetic resonance imaging revealed a 1.3 × 1.7 × 1.4 cm abscess encompassing the right Meckel's cave. A computed tomography scan showed petrous apicitis and otomastoiditis, confirming Gradenigo's syndrome. The patient was taken to the operating theatre for right intact canal wall mastoidectomy with myringotomy and tube placement. She was discharged on six weeks of ceftriaxone administered by a peripherally inserted central catheter line. At a two-week post-operative visit, she showed notable improvement in neuropathic symptoms.
This study presents a rare case of petrous apicitis managed surgically without the need for a craniotomy or transcochlear procedure.
We prove the stability with respect to the flux of solutions to initial – boundary value problems for scalar non autonomous conservation laws in one space dimension. Key estimates are obtained through a careful construction of the solutions.
The value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate the transdiagnostic dimensional structure and associated characteristics of psychopathology at First Episode Psychosis (FEP). Regardless of diagnostic categories, we expected that positive symptoms occurred more frequently in ethnic minority groups and in more densely populated environments, and that negative symptoms were associated with indices of neurodevelopmental impairment.
This study included 2182 FEP individuals recruited across six countries, as part of the EUropean network of national schizophrenia networks studying Gene–Environment Interactions (EU-GEI) study. Symptom ratings were analysed using multidimensional item response modelling in Mplus to estimate five theory-based models of psychosis. We used multiple regression models to examine demographic and context factors associated with symptom dimensions.
A bifactor model, composed of one general factor and five specific dimensions of positive, negative, disorganization, manic and depressive symptoms, best-represented associations among ratings of psychotic symptoms. Positive symptoms were more common in ethnic minority groups. Urbanicity was associated with a higher score on the general factor. Men presented with more negative and less depressive symptoms than women. Early age-at-first-contact with psychiatric services was associated with higher scores on negative, disorganized, and manic symptom dimensions.
Our results suggest that the bifactor model of psychopathology holds across diagnostic categories of non-affective and affective psychosis at FEP, and demographic and context determinants map onto general and specific symptom dimensions. These findings have implications for tailoring symptom-specific treatments and inform research into the mood-psychosis spectrum.
Piglets can often suffer impaired antioxidant status and poor immune response during post-weaning, especially when chronic inflammation takes place, leading to lower growth rates than expected. Oral administration of dietary antioxidant compounds during this period could be a feasible way to balance oxidation processes and increase health and growth performance. The aim of the trial was to study the effects of an antioxidant feed supplement (melon pulp concentrate) that contains high concentration of the antioxidant superoxide dismutase (SOD) on inflammation, antioxidant status and growth performance of lipopolysaccharide (LPS) challenged weaned piglets. In total, 48 weaned piglets were individually allocated to four experimental groups in a 2×2 factorial design for 29 days. Two different dietary treatments were adopted: (a) control (CTR), fed a basal diet, (b) treatment (MPC), fed the basal diet plus 30 g/ton of melon pulp concentrate. On days 19, 21, 23 and 25 half of the animals within CTR and MPC groups were subjected to a challenge with intramuscular injections of an increasing dosage of LPS from Escherichia coli (serotype 0.55:B5) (+) or were injected with an equal amount of PBS solution (−). Blood samples were collected at the beginning of the trial and under the challenge period for interleukin 1β, interleukin 6, tumour necrosis factor α, haptoglobin, plasma SOD activity, total antioxidant capacity, reactive oxygen species, red blood cells and plasma resistance to haemolysis, and 8-oxo-7, 8-dihydro-2’-deoxyguanosine. Growth performance was evaluated weekly. A positive effect of melon pulp concentrate was evidenced on total antioxidant capacity, half-haemolysis time of red blood cells, average daily gain (ADG) and feed intake, while LPS challenge increased pro-inflammatory cytokines and haptoglobin serum concentrations, with a reduced feed intake and gain : feed (G : F). The obtained results show that oral SOD supplementation with melon pulp concentrate ameliorates the total antioxidant capacity and the half-haemolysis time in red blood cell of post-weaning piglets, with positive results on growing performance.
The aim of this review is to focus the attention on the nutrition ecology of the heavy metals and on the major criticisms related to the heavy metals content in animal feeds, manure, soil and animal-origin products. Heavy metals are metallic elements that have a high density that have progressively accumulated in the food chain with negative effects for human health. Some metals are essential (Fe, I, Co, Zn, Cu, Mn, Mo, Se) to maintain various physiological functions and are usually added as nutritional additives in animal feed. Other metals (As, Cd, F, Pb, Hg) have no established biological functions and are considered as contaminants/undesirable substances. The European Union adopted several measures in order to control their presence in the environment, as a result of human activities such as: farming, industry or food processing and storage contamination. The control of the animal input could be an effective strategy to reduce human health risks related to the consumption of animal-origin products and the environmental pollution by manure. Different management of raw materials and feed, animal species as well as different legal limits can influence the spread of heavy metals. To set up effective strategies against heavy metals the complex interrelationships in rural processes, the widely variability of farming practices, the soil and climatic conditions must be considered. Innovative and sustainable approaches have discussed for the heavy metal nutrition ecology to control the environmental pollution from livestock-related activities.
Between 1996 and 2009, a process of struggle for and (after 2002) partial achievement of the second incorporation of the popular sectors took place in Argentina. This process involved a combination of routine and contentious political dynamics that reformulated state-society relations in the postcorporatist period. As a continuation of the first incorporation (1943–55), the second incorporation displayed some similar features; other attributes were specific to this second process, mainly that it was not corporatist but territorial and that the central agents of transformation were not trade unions but the disincorporated popular sectors, which were territorially organized into a “reincorporation movement.” This article conceptualizes these dynamics and analyzes the role played by the main political actor related to this historical process, the piquetero (picketer) movement.
In this paper we analyse possible extensions of the classical Steklov eigenvalue problem to the fractional setting. In particular, we find a non-local eigenvalue problem of fractional type that approximates, when taking a suitable limit, the classical Steklov eigenvalue problem.
Five turquoise samples, belonging to the XVII century historical collection of the Real Museo Mineralogico (University of Naples Federico II), were investigated by a multi-methodological approach based on powder X-ray diffraction, electron microprobe analysis in wavelength-dispersive spectroscopy mode, backscattered electron images from scanning electron microscopy in energy-dispersive spectroscopy mode, laser ablation inductively coupled plasma mass spectrometry, Fourier transform infrared and Raman spectroscopy.
The samples originate from Sinai (Egypt), Santa Fè S. Miguel (New Mexico), Saxony (Germany), Montebras Creuse (France) and Nishapur (Khorassan, Iran) and display different mineralogical compositions and various mineral associations. The study has shown the presence of: (1) four minerals of the turquoise group: turquoise, faustite, chalcosiderite and planerite; (2) other phosphates from different groups: wavellite, crandallite, goyazite, gorceixite, variscite, metavariscite, fluorapatite; and (3) other minerals: voltaite, adularia and quartz.
The present investigation is intended to show the mineralogical and geochemical variability of the samples with particular attention to the mineralogical parageneses, textural analyses and trace-element concentrations.
The increased use of the MATRICS Consensus Cognitive Battery (MCCB) to investigate cognitive dysfunctions in schizophrenia fostered interest in its sensitivity in the context of family studies. As various measures of the same cognitive domains may have different power to distinguish between unaffected relatives of patients and controls, the relative sensitivity of MCCB tests for relative–control differences has to be established. We compared MCCB scores of 852 outpatients with schizophrenia (SCZ) with those of 342 unaffected relatives (REL) and a normative Italian sample of 774 healthy subjects (HCS). We examined familial aggregation of cognitive impairment by investigating within-family prediction of MCCB scores based on probands’ scores.
Multivariate analysis of variance was used to analyze group differences in adjusted MCCB scores. Weighted least-squares analysis was used to investigate whether probands’ MCCB scores predicted REL neurocognitive performance.
SCZ were significantly impaired on all MCCB domains. REL had intermediate scores between SCZ and HCS, showing a similar pattern of impairment, except for social cognition. Proband's scores significantly predicted REL MCCB scores on all domains except for visual learning.
In a large sample of stable patients with schizophrenia, living in the community, and in their unaffected relatives, MCCB demonstrated sensitivity to cognitive deficits in both groups. Our findings of significant within-family prediction of MCCB scores might reflect disease-related genetic or environmental factors.
Cardiac progenitor cells (CPCs) are a promising candidate for cardiac regeneration, and the interaction between CPCs and their microenvironment can influence their regenerative response. Notch signaling plays a key role in cell fate decisions in the developing and adult heart. Here, we investigated the effect of three-dimensional (3D) spheroid culture, as a model of the 3D microenvironment, on Notch in fetal and adult human CPCs, under room air (20%) and physiological (5%) oxygen tension. Notch signaling is enhanced in 3D spheroids; spheroid culture under 5% O2 further increases Notch signaling enhancement, and might ultimately improve the regenerative potential of CPCs.
This book offers an innovative perspective on the ever-widening gap between the poor and the state in Latin American politics. It presents a comprehensive analysis of the main social movement that mobilized the poor and unemployed people of Argentina to end neoliberalism and to attain incorporation into a more inclusive and equal society. The piquetero (picketer) movement is the largest movement of unemployed people in the world. This movement has transformed Argentine politics to the extent of becoming part of the governing coalition for more than a decade. Rossi argues that the movement has been part of a long-term struggle by the poor for socio-political participation in the polity after having been excluded by authoritarian regimes and neoliberal reforms. He conceptualizes this process as a wave of incorporation, exploring the characteristics of this major redefinition of politics in Latin America.