Background. Gilles de la Tourette's syndrome (GTS)
familial neuropsychiatric disorder characterized by tics and
obsessive–compulsive behaviours (OCB). Previous HMPAO SPET
studies of subjects with GTS have shown hypoperfusion of striatal and frontal
areas. Studies of
patients with primary obsessive–compulsive disorder have shown, in
hyperperfusion of similar areas.
Methods. Twenty subjects from five families affected by GTS,
individuals with OCB but no tics, were examined using HMPAO SPET.
Results. There were abnormalities of regional cerebral perfusion
individuals with GTS, OCB and tics. Hypoperfusion was in striatal, frontal
temporal areas. There was no hyperperfusion.
Conclusions. Regional cerebral blood flow patterns in individuals
with OCB in families affected
by GTS are comparable to their relatives with GTS and differ from individuals
with primary OCD in the absence of a family history of tic disorders.