To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
We have investigated the effect of oxygen pressure during growth (PO2) on the electronic and magnetic properties of PrAlO3 films grown on TiO2-terminated SrTiO3 substrates. The films are smooth, with flat terraces. Resistivity measurements show an increase in the sheet resistance as PO2 is increased from 10–3 to 10–4 torr, with an usual peak as a function of temperature for the sample grown in higher oxygen pressure. We measured a moderate positive magnetoresistance (MR) at low magnetic fields that evolves into a larger negative MR at high fields, for both PO2 samples. Hall effect data exhibit a complex temperature dependence that suggests a compensated carrier density. We observe behavior consistent with two different types of carriers at each of the two different interfaces.
Frank Tufaro, Allera Health Products, Inc., 360 Central Avenue, Suite 1560, St. Petersburg, FL 33701, USA,
James M. Markert, University of British Columbia, British Columbia, Canada; Department of Surgery, Brain Tumor Research Laboratories, The University of Alabama at Birmingham, Birmingham, AL, USA
After more than a decade of intensive research and development efforts, the translation of promising viral-based gene therapies from the research lab to the clinic is both promising and unexpectedly challenging. Many of the same properties that make viral vectors attractive candidates to deliver genes for therapeutic purposes also impede the path to successful clinical development.
Vectors for clinical use must be manufactured in relatively high yields such that hundreds of thousands or even millions of “doses” can be generated in a safe and cost-effective manner. Moreover, the resulting vector must exhibit genetic as well as structural stability, withstand storage at various temperatures for up to several years, and cause little or no toxicity in animals, and ultimately in humans.
Herpes simplex viruses (HSV), while widespread in nature, have not been tested in human clinical studies as often as several other commonly used vectors, such as adenovirus, adeno-associated viruses (AAV), and retroviruses. In many ways however, HSV is emerging as a viable therapeutic platform and several clinical studies are either ongoing or planned for the very near future. The reason for this increased focus on HSV is due in part attributable to the unique properties that make HSV a stable and potentially potent vector for controlled gene delivery. In addition, the increasing experience with replication-competent vectors in human clinical studies has made it more familiar with clinicians.
Properties of therapeutic HSV vectors
Therapeutic HSV can be characterized as replication-competent or replication-defective.
A 63nm Twin Flash memory cell with a size of 0.0225μm2 per 2 (or 4) bits is presented. To achieve small cell areas, a buried bit line and an aggressive gate length of 100 nm are the key features of this cell together with a minimum thermal budget processing. A novel epitaxial CoSi2 process allows the salicidation of local buried bitlines with only a few tens of nanometer width.
High resolution X-ray spectral observations of Puppis A were performed with the FPCS on Einstein. We use plasma diagnostics of lines from OVII and OVIII to constrain the values of temperature, ionization timescale, and hydrogen column density.
The topic of this paper really falls somewhere between this session on active galaxies and the session on clusters. What I will report is really a cluster phenomenon but one which depends on the presence of a dominant, massive galaxy in the cluster. Specifically, we have detected several X-ray emission lines from the vicinity of M87 in the Virgo Cluster and NGC 1275 in Perseus. The lines are indicative of material which is cooler than the bulk of the intracluster gas. This material is most likely accreting onto the central galaxy with the accretion rate controlled by the rate of radiative cooling.
The observations I am reporting were made with the Focal Plane Crystal Spectrometer (FPCS)on the Einstein Observatory. The instrument is a Bragg crystal spectrometer which has a resolving power (E/ΔE) of 50 to 500 over the energy range of 0.2 to 3 keV. It operates much like an optical scanner in that it has a narrow passband which is swept over some restricted spectral range containing an emission line. Detailed descriptions are given elsewhere (Canizares et al. 1977, 1979, Giacconi et al. 1979).
Email your librarian or administrator to recommend adding this to your organisation's collection.