Recent core drillings, carried out during water-economic exploration in the area of Mannheim/Ludwigshafen/Schifferstadt (Rhine-Neckar region, Germany), have produced a more differentiated stratigraphic division of the Pleistocene sediments of the northern Upper Rhine Graben. Pollen analytical investigations as well as malacological, heavy mineral, palaeomagnetic and lithological research have led to a stratigraphic reinterpretation of the gravel layers and intermediate horizons. Based on the results of the pollen analyses, the Mannheim interglacial period in the upper intermediate horizon (Oberer Zwischenhorizont, OZH) cannot be assigned to the Eemian as stated earlier. The occurrence of Fagus, Celtis and Azolla, along with the results of malacological analyses, indicate a Cromerian age for the Mannheim Interglacial. In addition, a pollen sequence from a different interglacial in the core sediments from Schifferstadt could also be assigned to the Cromerian. The Schifferstadt Interglacial is divided into a lower optimum phase with high values of Ulmus, Quercus and Corylus while Carpinus is completely absent, and an upper optimum phase with low values of Carpinus. Fagus is absent in the whole sequence. The OZH comprises not only the two interglacial pollen sequences described above but also parts of at least four Middle Pleistocene Interglacials. In the lower part of the drillings in Schifferstadt and Ludwigshafen, which are assigned to the Early Pleistocene, pollen assemblages with Fagus are likely to correlate with parts of the Tiglian A substage. There is a clear change to a Tertiary type of pollen flora at 91 m at Schifferstadt and at 186 m in Ludwigshafen.