Sleep has been shown to impact on both physical and mental health, and sleep problems present a considerable burden for individuals and society. There appears to be a complex bidirectional relationship between sleep disturbance and psychiatric symptoms, each potentially influencing the other. In particular, sleep disorders have been associated with more severe symptoms and are predictive of relapse in those with psychotic disorders. This article discusses the relationship between psychosis and insomnia, sleep apnoea, nightmares, circadian rhythm abnormalities and the impact of medications on these relationships. We also discuss the clinical implications of the relationship between sleep disturbance and psychotic disorders along with potential targets for intervention.

A consensus workshop on low-calorie sweeteners (LCS) was held in November 2018 where seventeen experts (the panel) discussed three themes identified as key to the science and policy of LCS: (1) weight management and glucose control; (2) consumption, safety and perception; (3) nutrition policy. The aims were to identify the reliable facts on LCS, suggest research gaps and propose future actions. The panel agreed that the safety of LCS is demonstrated by a substantial body of evidence reviewed by regulatory experts and current levels of consumption, even for high users, are within agreed safety margins. However, better risk communication is needed. More emphasis is required on the role of LCS in helping individuals reduce their sugar and energy intake, which is a public health priority. Based on reviews of clinical evidence to date, the panel concluded that LCS can be beneficial for weight management when they are used to replace sugar in products consumed in the diet (without energy substitution). The available evidence suggests no grounds for concerns about adverse effects of LCS on sweet preference, appetite or glucose control; indeed, LCS may improve diabetic control and dietary compliance. Regarding effects on the human gut microbiota, data are limited and do not provide adequate evidence that LCS affect gut health at doses relevant to human use. The panel identified research priorities, including collation of the totality of evidence on LCS and body weight control, monitoring and modelling of LCS intakes, impacts on sugar reduction and diet quality and developing effective communication strategies to foster informed choice. There is also a need to reconcile policy discrepancies between organisations and reduce regulatory hurdles that impede low-energy product development and reformulation.

The term ‘sweeteners’ encompasses both nutritive and non-nutritive sweeteners, which when added to food/beverages, can enhance the flavour and other functional properties of food/beverage products. This review considers how dietary biomarker approaches may enhance current understanding of nutritive sweetener (namely free sugars) and non-nutritive or low-energy sweetener (LES) intakes and how these may impact health. Recent public health strategies to reduce free sugar consumption will help contribute to challenging sugar intake targets. Robust evaluation is needed to determine the effectiveness of these approaches to reducing free sugar consumption. LES provides a sweet taste without the addition of appreciable energy and can help maintain the palatability of reformulated products. All LES undergo rigorous safety evaluations prior to approval for use. Whilst intervention data suggest LES can be beneficial for health (relating to weight status and glycaemic control), debate persists on their use and findings from population-based research are mixed, in part because of potential contributing factors such as reverse causality. Additionally, assessments often consider only certain sources of LES (e.g. LES-beverages) and/or LES as a homogeneous group despite differing biological fates, thus not adequately capturing intakes of individual LES or allowing for reliable estimation of overall intakes. Urinary biomarker approaches developed/investigated for sweetener consumption have the potential to overcome existing limitations of dietary data by providing more objective intake data, thereby enhancing population-based research. In conclusion, such biomarker approaches to the concomitant study of free sugars and LES intakes are timely and represent interesting developments in an area of significant public health interest.

We use deep Chandra and HST data to uniquely classify the X-ray binary (XRB) populations in M81 on the basis of their donor stars and local stellar populations (into early-type main sequence, yellow giant, supergiant, low-mass, and globular cluster). First, we find that more massive, redder, and denser globular clusters are more likely to be associated with XRBs. Second, we find that the high-mass XRBs (HMXBs) overall have a steeper X-ray luminosity function (XLF) than the canonical star-forming galaxy XLF, though there is some evidence of variations in the slopes of the sub-populations. On the other hand, the XLF of the prototypical starburst M82 is described by the canonical powerlaw (αcum ∼ 0.6) down to LX ∼ 1036 erg s−1. We attribute variations in XLF slopes to different mass transfer modes (Roche-lobe overflow versus wind-fed systems).

We consider the problem of a rigid plate, inclined at an angle $\unicode[STIX]{x1D6FC}\in (0,\unicode[STIX]{x03C0}/2)$ to the horizontal, accelerating uniformly from rest into, or away from, a semi-infinite strip of inviscid, incompressible fluid under gravity. Following on from Gallagher et al. (J. Fluid Mech., vol. 841, 2018, pp. 109–145) (henceforth referred to as GNB), it is of interest to analyse the well-posedness and stability of the principal flow with respect to perturbations in the initially horizontal free surface close to the plate contact point. In particular we find that the solution to the principal unperturbed problem, denoted by [IBVP] in GNB, is well-posed and stable with respect to perturbations in initial data in the region of interest, localised close to the contact point of the free surface and the plate, when the plate is accelerated with dimensionless acceleration $\unicode[STIX]{x1D70E}\geqslant -\cot \,\unicode[STIX]{x1D6FC}$ , while the solution to [IBVP] is ill-posed with respect to such perturbations in the initial data, when the plate is accelerated with dimensionless acceleration $\unicode[STIX]{x1D70E}<-\cot \,\unicode[STIX]{x1D6FC}$ . The physical source of the ill-posedness of the principal problem [IBVP], when $\unicode[STIX]{x1D70E}<-\cot \,\unicode[STIX]{x1D6FC}$ , is revealed to be due to the leading-order problem in the innermost region localised close to the initial contact point being in the form of a local Rayleigh–Taylor problem. As a consequence of this mechanistic interpretation we anticipate that, when the plate is accelerated with $\unicode[STIX]{x1D70E}<-\cot \,\unicode[STIX]{x1D6FC}$ , the inclusion of weak surface tension effects will restore well-posedness of the problem [IBVP] which will, however, remain temporally unstable.

The free surface and flow field structure generated by the uniform acceleration (with dimensionless acceleration  $\unicode[STIX]{x1D70E}$ ) of a rigid plate, inclined at an angle $\unicode[STIX]{x1D6FC}\in (0,\unicode[STIX]{x03C0}/2)$ to the exterior horizontal, as it advances ( $\unicode[STIX]{x1D70E}>0$ ) or retreats ( $\unicode[STIX]{x1D70E}<0$ ) from an initially stationary and horizontal strip of inviscid incompressible fluid under gravity, are studied in the small-time limit via the method of matched asymptotic expansions. This work generalises the case of a uniformly accelerating plate advancing into a fluid as studied by Needham et al. (Q. J. Mech. Appl. Maths, vol. 61 (4), 2008, pp. 581–614). Particular attention is paid to the innermost asymptotic regions encompassing the initial interaction between the plate and the free surface. We find that the structure of the solution to the governing initial boundary value problem is characterised in terms of the parameters $\unicode[STIX]{x1D6FC}$ and $\unicode[STIX]{x1D707}$ (where $\unicode[STIX]{x1D707}=1+\unicode[STIX]{x1D70E}\tan \unicode[STIX]{x1D6FC}$ ), with a bifurcation in structure as $\unicode[STIX]{x1D707}$ changes sign. This bifurcation in structure leads us to question the well-posedness and stability of the governing initial boundary value problem with respect to small perturbations in initial data in the innermost asymptotic regions, the discussion of which will be presented in the companion paper Gallagher et al. (J. Fluid Mech. vol. 841, 2018, pp. 146–166). In particular, when $(\unicode[STIX]{x1D6FC},\unicode[STIX]{x1D707})\in (0,\unicode[STIX]{x03C0}/2)\times \mathbb{R}^{+}$ , the free surface close to the initial contact point remains monotone, and encompasses a swelling jet when $(\unicode[STIX]{x1D6FC},\unicode[STIX]{x1D707})\in (0,\unicode[STIX]{x03C0}/2)\times [1,\infty )$ or a collapsing jet when $(\unicode[STIX]{x1D6FC},\unicode[STIX]{x1D707})\in (0,\unicode[STIX]{x03C0}/2)\times (0,1)$ . However, when $(\unicode[STIX]{x1D6FC},\unicode[STIX]{x1D707})\in (0,\unicode[STIX]{x03C0}/2)\times \mathbb{R}^{-}$ , the collapsing jet develops a more complex structure, with the free surface close to the initial contact point now developing a finite number of local oscillations, with near resonance type behaviour occurring close to a countable set of critical plate angles $\unicode[STIX]{x1D6FC}=\unicode[STIX]{x1D6FC}_{n}^{\ast }\in (0,\unicode[STIX]{x03C0}/2)$ ( $n=1,2,\ldots$ ).

We present our latest 3D model atmospheres for carbon-enhanced metal-poor (CEMP) stars computed with the CO5BOLD code. The stellar parameters are representative of hot turn-off objects (Teff ~ 6250 K, log g = 4.0, [Fe/H]=−3). The main purpose of these models is to investigate the role of 3D effects on synthetic spectra of the CH G-band (4140-4400 Å), the CN BX-band (3870-3890 Å), and several UV OH transitions (3122-3128 Å). By comparison with the synthetic spectra from standard 1D model atmospheres (assuming local thermodynamic equilibrium, LTE), we derive 3D abundance corrections for carbon and oxygen of up to −0.5 and −0.7 dex, respectively.

Aberrant microbiota composition and function have been linked to several pathologies, including type 2 diabetes. In animal models, prebiotics induce favourable changes in the intestinal microbiota, intestinal permeability (IP) and endotoxaemia, which are linked to concurrent improvement in glucose tolerance. This is the first study to investigate the link between IP, glucose tolerance and intestinal bacteria in human type 2 diabetes. In all, twenty-nine men with well-controlled type 2 diabetes were randomised to a prebiotic (galacto-oligosaccharide mixture) or placebo (maltodextrin) supplement (5·5 g/d for 12 weeks). Intestinal microbial community structure, IP, endotoxaemia, inflammatory markers and glucose tolerance were assessed at baseline and post intervention. IP was estimated by the urinary recovery of oral 51Cr-EDTA and glucose tolerance by insulin-modified intravenous glucose tolerance test. Intestinal microbial community analysis was performed by high-throughput next-generation sequencing of 16S rRNA amplicons and quantitative PCR. Prebiotic fibre supplementation had no significant effects on clinical outcomes or bacterial abundances compared with placebo; however, changes in the bacterial family Veillonellaceae correlated inversely with changes in glucose response and IL-6 levels (r −0·90, P=0·042 for both) following prebiotic intake. The absence of significant changes to the microbial community structure at a prebiotic dosage/length of supplementation shown to be effective in healthy individuals is an important finding. We propose that concurrent metformin treatment and the high heterogeneity of human type 2 diabetes may have played a significant role. The current study does not provide evidence for the role of prebiotics in the treatment of type 2 diabetes.

Background: Understanding the epidemiology of traumatic brain injury (TBI) is essential to shape public health policy, implement prevention strategies, and justify allocation of resources toward research, education, and rehabilitation in TBI. There is not, to our knowledge, a systematic review of population-based studies addressing the epidemiology of TBI that includes all subtypes. We performed a comprehensive systematic review and meta-analysis of the worldwide incidence of TBI. Methods: A search was conducted on May 23, 2014, in Medline and EMBASE according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Abstracts were screened independently and in duplicate to identify original research. Study quality and ascertainment bias were assessed in duplicate using a previously published tool. Demographic data and incidence estimates from each study were recorded, along with stratification by age, gender, year of data collection, and severity. Results: The search strategy yielded 4944 citations. Two hundred and sixteen articles met criteria for full-text review; 144 were excluded. Hand searching resulted in ten additional articles. Eighty-two studies met all eligibility criteria. The pooled annual incidence proportion for all ages was 295 per 100,000 (95% confidence interval: 274-317). The pooled incidence rate for all ages was 349 (95% confidence interval: 96.2-1266) per 100,000 person-years. Incidence proportion and incidence rate were examined to see if associated with age, sex, country, or severity. Conclusions: We conclude that most TBIs are mild and most TBIs occur in males among the adult population. The incidence of TBI varies widely by ages and between countries. Despite being an important medical, economic, and social problem, the global epidemiology of TBI is still not well-characterized in the current literature. Understanding the incidence of TBI, particularly mild TBI, remains challenging because of nonstandardized reporting among neuroepidemiological studies.

Background: Postoperative infection is a significant cause of morbidity and mortality in traumatic brain injury (TBI) patients who undergo craniotomy and/or craniectomy. Data on the rates of infections associated with these procedures are limited. We present a single-center retrospective study on the rates of infection in post-traumatic craniotomies, craniectomies and cranioplasties. Methods: Data on 100 TBI adult patients who underwent a craniotomy, craniectomy and/or cranioplasty from 2011-2015 will be analyzed. Demographic and perioperative data including open/closed TBI, peri/postoperative infections, duration of procedure, type and mode of bone flap preservation will be retrieved. Results: Following our data collection (to be completed by the end of February), we expect infection rates of 3-20% in our study. Upon instituting a protocol similar to the Hydrocephalus Clinical Research Network’s (HCRN) ventriculoperitoneal shunt (VP) protocol, we hope to reduce our post-TBI craniotomy/craniectomy/cranioplasty infections rates to less than 10%. Our projection is based on the HCRN protocol’s 3.15% absolute risk reduction of VP shunt infections. Conclusions: The results of this study will emphasize the need for instituting robust perioperative protocols to reduce infections. Further research will be pursued following this study to establish a protocol similar to the VP shunt protocol from the HCRN, in an attempt to reduce perioperative rates of infection.

We present results, some preliminary, from a major new study of the star formation properties of a sample of nearby disk galaxies (Ferguson 1997). Our emphasis is on the faint outer regions of disks. Hα images, combined with broad-band images and spectroscopy of HII regions, constrain the present and past star formation rates and chemical enrichment. These data also allow study of faint diffuse ionised gas, which traces the influence of massive stars on their environment, and the structure of the interstellar medium.

Low-calorie sweeteners (LCS) are commonly used as sugar substitutes in the diet to provide a desired sweet taste without increased energy intake. The number of LCS available on the market has increased considerably over the years and despite extensive evaluation of their safety prior to approval, debate continues around the effects of consumption on health. In Europe, Member States are obligated to monitor exposure to LCS and methods currently used tend to rely on self-reported dietary intake data alongside LCS concentrations in products. However, the acquisition of accurate data can be costly in terms of resources and time and are inherently imprecise. Although LCS are intensely sweet, they are chemically diverse and a limitation of many studies investigating the health effects of consumption is that they often fail to discern intakes of individual LCS. An approach which objectively assesses intakes of individual LCS would therefore allow robust investigations of their possible effects on health. Biomarker approaches have been utilised for the objective investigation of intakes of a range of dietary components and the feasibility of any such approach depends upon its validity as well as its applicability within the target population. This review aims to provide an overview of current understanding of LCS intake and explore the possibility of implementing a biomarker approach to enhance such understanding. Several commonly used LCS, once absorbed into the body, are excreted via the kidneys; therefore a urinary biomarker approach may be possible for the investigation of short-term exposure to these compounds.