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Antibiotic prescribing practices across the Veterans’ Health Administration (VA) experienced significant shifts during the coronavirus disease 2019 (COVID-19) pandemic. From 2015 to 2019, antibiotic use between January and May decreased from 638 to 602 days of therapy (DOT) per 1,000 days present (DP), while the corresponding months in 2020 saw antibiotic utilization rise to 628 DOT per 1,000 DP.
Recent studies suggest that depression is associated with somatic pain. Despite growing research interest in the topic, the effects of depression-related somatic pain remain unclear. The present study sought to investigate the relationships between depression-related somatic pain, treatment satisfaction, and functions of daily living, and to compare them with the relationships between these factors and mental health measures.
We administered an Internet-based survey to 663 patients with depression in Japan, including questions about pain symptoms, mental health, functions of daily living, and dissatisfaction with depression treatment. The SF-8 questionnaire was used to assess functions of daily living. We conducted a multiple linear regression analysis to examine the associations between depression-related somatic pain, functions of daily living and treatment satisfaction, and between mental health measures, somatic pain and functions of daily living.
An increase per unit in the number of pain symptoms was associated with a 1.04-unit decrease in physical functioning score (P < 0.001), a 0.67-unit decrease in the role functioning-physical score (P < 0.001), and a 0.53-unit decrease in role functioning-emotional score (P = 0.0010). Meanwhile, we found no significant association between the number of pain symptoms and patients’ satisfaction with treatment, and no significant association between the number of pain symptoms and social functioning.
These results suggest that even when patients report satisfaction with their treatment, they may be suffering from reduced physical functioning and role functioning. These impairments may escape clinical recognition when clinicians or patients fail to discuss pain symptoms.
Considering the ample evidence of involvement of the glutamate system in the pathophysiology of depression, pre-clinical and clinical studies have been conducted to assess the antidepressant efficacy of glutamate inhibition, and glutamate receptor modulators in particular. This review focuses on the use of glutamate receptor modulators in unipolar depression.
A method is developed to adjust a vorticity field to satisfy specified values for a finite number of Casimir invariants. The developed method is tested numerically for a neutral fluid in two dimensions. The adjusted vorticity field is adopted as an initial condition for simulated annealing (SA) of an incompressible, ideal neutral fluid and its magnetohydrodynamics (MHD), where SA enables us to obtain a stationary state of the fluid. Since the Casimir invariants are kept unchanged during the annealing process, the obtained stationary state has the required values of the Casimir invariants specified by our method.
We have numerically solved the coupled ordinary differential equations (ODEs) representing the ballooning modes in toroidally rotating tokamaks. The ODEs were derived by the eigenfunction expansion of the ballooning mode, of which the governing equation was originally derived as a partial differential equation (PDE). Generally, the truncation of the coupled ODEs to a finite number can generate essential differences between the solutions to the ODEs and to the corresponding PDE, because the truncation reduces the degree of freedom of the motion of the oscillators, or the expansion coefficients. The comparison between the solutions shows that the regularized eigenfunctions used for the expansion, developed by Furukawa and Tokuda (2005 Phys. Rev. Lett.94, 175001), efficiently confine the motion of the oscillators in the phase space with a small number of dimensions; the solution to the truncated ODEs can approximate well the ballooning mode obtained as a solution to the corresponding PDE within a finite time.
It is shown that the exact nonlinear solution for the Hall–Alfvén waves can be obtained in a uniformly rotating weakly ionized plasma such as those which exist in various types of accretion disks. In addition this piece of work demonstrates a method of eliminating the inaccuracies embedded in the literature on this subject.
A 54-year-old man complained of severe throat pain and showed subglottic oedema on fibre-optic endoscopy with a distinctly narrowed subglottic space on anteroposterior radiography of the neck and dense linear opacity at the level of the cricoid cartilage on lateral plain radiography. These findings suggested a foreign body just posterior to the cricopharyngeus, but a computed tomography (CT) scan demonstrated a dense calcified ridge on the posterior lamina of the cricoid cartilage but no foreign body.
The patient improved symptomatically with systemic antibiotics and topical steroids, and gastrointestinal endoscopy did not detect any foreign body. This is a rare case of vertical ossification of the cricoid lamina masquerading as a foreign body.
A novel tantalum precursor, bis(ethylcyclopentadienyl)hydridocarbonyltantalum (Ta(EtCp)2(CO)H EtCp:ethylcyclopentadienyl), for chemical vapor deposition (CVD) and atomic layer deposition (ALD) was synthesized. The molecular structure of this precursor was determined by 1H and 13C NMR, IR, ICP-AES and elemental analysis. This precursor is liquid at room temperature, and its vapor pressure and decomposition temperature indicates that this precursor is suitable for CVD and ALD process.
The composition analysis of metal tantalum films deposited by thermal CVD revealed that the concentration of carbon was larger than tantalum. On the other hand, an argon plasma CVD technique reduced the carbon concentration drastically.