Systems of weed control composed of (a) intensive cultivation only, (b) herbicides only, or (c) herbicides plus cultivation controlled weeds in soybeans (Glycine max (L.) Merr.) with acceptable crop tolerance. On Ocilla sandy loam, systems with S-propyl dipropylthiocarbamate (vernolate) as a preplanting treatment and 3[p-(p-chlorophenoxy)phenyl]-1,1-dimethylurea (chloroxuron) as an early postemergence treatment, followed by either sweep cultivations or directed postemergence applications of other herbicides, controlled yellow nutsedge (Cyperus esculentus L.) satisfactorily and controlled 99 to 100% of the common cocklebur (Xanthium pensylvanicum Wallr.) and Florida beggarweed [Desmodium tortuosum (Sw.) DC.]. As directed postemergence treatment, 2-seobutyl-4,6-dinitrophenol (dinoseb) controlled common cocklebur and Florida beggarweed about as well as 3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea (linuron). However, for the broad spectrum of weeds encountered on the Greenville soil, linuron was superior to dinoseb, especially on Texas panicum (Panicum texanum Buckl.). Systems containing only cultivation controlled 84 to 98% of the common cocklebur and 78 to 99% of the Florida beggarweed. On Greenville sandy clay loam, several systems of weed control significantly reduced the stand but not the yield of soybeans. Vernolate reduced stands when used as a preplanting incorporated treatment but not when injected at planting. No significant yield differences among the weed control systems were apparent in the 3-year averages. Costs of weed control ranged from $20 to $30/ha for cultivation only, from $55 to $73/ha for herbicides only, and from $45 to $53/ha for herbicides combined with cultivation. Uncontrolled weeds, primarily common cocklebur and Florida beggarweed, in the weedy check plots reduced the average yield of soybeans 74% on the Ocilla soil during the 3-year period. The different systems of weed control did not affect commercial quality of soybean oil.