Catecholaminergic polymorphic ventricular tachycardia is an ion channelopathy, caused by mutations in genes coding for calcium-handling proteins. It can coexist with left ventricular non-compaction. We aim to investigate the clinical and genetic characteristics of this co-phenotype.

Medical records of 24 patients diagnosed with catecholaminergic polymorphic ventricular tachycardia in two Chinese hospitals between September, 2005, and January, 2020, were retrospectively reviewed. We evaluated their clinical and genetic characteristics, including basic demographic data, electrocardiogram parameters, medications and survival during follow-up, and their gene mutations. We did structural analysis for a novel variant ryanodine receptor 2-E4005V.

The patients included 19 with catecholaminergic polymorphic ventricular tachycardia mono-phenotype and 5 catecholaminergic polymorphic ventricular tachycardia-left ventricular non-compaction overlap patients. The median age of onset symptoms was 9.0 (8.0,13.5) years. Most patients (91.7%) had cardiac symptoms, and 50% had a family history of syncope. Overlap patients had lower peak heart rate and threshold heart rate for ventricular tachycardia and ventricular premature beat during the exercise stress test (p < 0.05). Sudden cardiac death risk may be higher in overlap patients during follow-up. Gene sequencing revealed 1 novel ryanodine receptor 2 missense mutation E4005V and 1 mutation previously unreported in catecholaminergic polymorphic ventricular tachycardia, but no left ventricular non-compaction-causing mutations were observed. In-silico analysis showed the novel mutation E4005V broke down the interaction between two charged residues.

Catecholaminergic polymorphic ventricular tachycardia overlapping with left ventricular non-compaction may lead to ventricular premature beat/ventricular tachycardia during exercise stress test at lower threshold heart rate than catecholaminergic polymorphic ventricular tachycardia alone; it may also indicate a worse prognosis and requires strict follow-up. ryanodine receptor 2 mutations disrupted interactions between residues and may interfere the function of ryanodine receptor 2.

COVID-19 lockdowns increased the risk of mental health problems, especially for children with autism spectrum disorder (ASD). However, despite its importance, little is known about the protective factors for ASD children during the lockdowns.

Based on the Shanghai Autism Early Developmental Cohort, 188 ASD children with two visits before and after the strict Omicron lockdown were included; 85 children were lockdown-free, while 52 and 51 children were under the longer and the shorter durations of strict lockdown, respectively. We tested the association of the lockdown group with the clinical improvement and also the modulation effects of parent/family-related factors on this association by linear regression/mixed-effect models. Within the social brain structures, we examined the voxel-wise interaction between the grey matter volume and the identified modulation effects.

Compared with the lockdown-free group, the ASD children experienced the longer duration of strict lockdown had less clinical improvement (β = 0.49, 95% confidence interval (CI) [0.19–0.79], p = 0.001) and this difference was greatest for social cognition (2.62 [0.94–4.30], p = 0.002). We found that this association was modulated by parental agreeableness in a protective way (−0.11 [−0.17 to −0.05], p = 0.002). This protective effect was enhanced in the ASD children with larger grey matter volumes in the brain's mentalizing network, including the temporal pole, the medial superior frontal gyrus, and the superior temporal gyrus.

This longitudinal neuroimaging cohort study identified that the parental agreeableness interacting with the ASD children's social brain development reduced the negative impact on clinical symptoms during the strict lockdown.

With the rapid development of society and the acceleration of people’s pace of life, the mental pressure of college students is increasing day by day, and bipolar disorder has become an important health problem they face. Traditional music education is regarded as an effective means of psychotherapy, which can alleviate emotional disorders. However, the current research on traditional music education in alleviating college students with bipolar disorder is still in the development stage, so this study attempts to explore the alleviating effect of traditional music education on college students with bipolar disorder.

The study designed an experimental group to receive a six-month course of traditional music education and a control group to receive a six-month course of traditional psychotherapy. SPSS23.0 software was used for the correlation test, and P<0.05 indicated that the difference was statistically significant. Both groups of students were tested before and after, and their changes in several aspects were analyzed.

The experimental group showed significant improvement in the alleviation of affective disorder, the improvement of self-adjustment ability, and the alleviation of anxiety and depression symptoms, and the difference was significant (P<0.05). However, the improvement of the control group was relatively low, and there were still some difficulties in emotional expression and social ability.

Traditional music education has a remarkable effect on alleviating bipolar disorder in college students, and it has a better effect than traditional psychotherapy. At the same time, it is of great significance to popularize and apply traditional music education in the field of college students’ mental health.

The increasingly prominent psychological anxiety of villagers in rural areas has a negative impact on their lives and well-being. It is of great significance to find effective mitigation methods. Research on the guiding effect of rural landscape design on villagers’ psychological anxiety from the perspective of design psychology can provide help for alleviating the psychological anxiety of rural residents.

In this study, 300 villagers from rural areas were selected as the experimental group among the villagers with psychological anxiety, who received teaching and appreciation of rural landscape design from the perspective of design psychology, while another 300 villagers from rural areas were selected as the control group, who did not receive relevant teaching and appreciation. The psychological Anxiety of the two groups of villagers was assessed by Beck Anxiety Inventory (BAI) once a quarter for a total of four quarters.

At the end of the first quarter, the average anxiety score was 20 in the experimental group and 25 in the control group. At the end of the fourth quarter, the average anxiety score was 12 for the experimental group and 24 for the control group. The anxiety of the experimental group was significantly lower than that of the control group.

Rural landscape design from the perspective of design psychology can effectively guide villagers’ psychological anxiety, and improve their emotional regulation ability and satisfaction with the rural environment. Therefore, rural areas should pay attention to the humanization and psychological orientation of landscape design to provide better psychological support and living environment for villagers.

Jiangxi University Humanities and Social Science Research Fund Project, Rural old-age landscape construction under the background of rural revitalization—a case study of the communist youth community in the communist youth city (No.YS21235).

The incidence of depression among college students is increasing year by year, which has a serious impact on social development. As a non-drug intervention, music therapy can affect individual psychological state through emotional catharsis, emotion regulation and other ways, which has attracted more and more attention in recent years, and is expected to provide an effective auxiliary means for the management of depression in college students.

A total of 200 college students were randomly divided into the control group and the experimental group. The students in the control group maintained their usual learning lifestyle. The experimental group received 30 minutes of music therapy four times a week for a total of 8 weeks. Beck Depression Checklist was used to evaluate the degree of depression symptoms, and SPSS statistical software was used to analyze the data.

The results showed that the mean score of depressive symptoms in the experimental group decreased from 28.4±5.2 before the intervention to 15.2±3.8 after the intervention, while the score of the control group decreased by less than 1 (P< 0.001). The BDI score of the music therapy group was significantly lower than that of the control group (P< 0.05), and the difference was statistically significant.

The results show that music therapy has a significant therapeutic effect on depression intervention of college students, which can effectively reduce the symptoms of depression and improve the emotional state of college students.

To examine the associations of pregnant women’s dietary and sedentary behaviours with their children’s birth weight.

Secondary data analysis was conducted using data from a randomised controlled trial, Communicating Healthy Beginnings Advice by Telephone, conducted in Australia. Information on mothers’ socio-demographics, dietary and sedentary behaviours during pregnancy was collected by telephone survey at the third trimester. Birth weight data were extracted from the child’s health record book. Multinomial logistic regression models were built to examine the associations of pregnant women’s dietary and sedentary behaviours with children’s birth weight.

Participating families.

Pregnant women and their children.

A total of 1132 mother–child dyads were included in the analysis. The majority of infants (87 %, n 989) were of normal birth weight (2500 g to <4000 g), 4 % (n 50) had low birth weight (<2500 g) and 8 % (n 93) had macrosomia (≥4000 g). Mothers who ate processed meat during pregnancy were more likely to have macrosomia (adjusted risk ratio (ARR) 1·80, 95 % CI (1·12, 2·89)). The risk of macrosomia decreased as the number of dietary recommendations met by mothers increased (ARR 0·84, 95 % CI (0·71, 0·99)). Children’s birth weight was not associated with mothers’ sedentary time. Children’s low birth weight was not associated with mothers’ dietary and sedentary behaviours during pregnancy.

Maternal consumption of processed meat during pregnancy was associated with an increased risk of macrosomia. Increasing number of dietary recommendations met by mothers was associated with a lower risk of macrosomia. The findings suggested encouraging pregnancy women to meet dietary recommendation will benefit children’s birth weight.

Parenting is a common and potent environmental factor influencing adolescent anxiety. Yet, the underlying neurobiological susceptibility signatures remain elusive. Here, we used a longitudinal twin neuroimaging study to investigate the brain network integration and its heritable relation to underpin the neural differential susceptibility of adolescent anxiety to parenting environments.

216 twins from the Beijing Twin Study completed the parenting and anxiety assessments and fMRI scanning. We first identified the brain network integration involved in the influences of parenting at age 12 on anxiety symptoms at age 15. We then estimated to what extent heritable sensitive factors are responsible for the susceptibility of brain network integration.

Consistent with the differential susceptibility theory, the results showed that hypo-connectivity within the central executive network amplified the impact of maternal hostility on anxiety symptoms. A high anti-correlation between the anterior salience and default mode networks played a similar modulatory role in the susceptibility of adolescent anxiety to paternal hostility. Genetic influences (21.18%) were observed for the connectivity pattern in the central executive network.

Brain network integration served as a promising neurobiological signature of the differential susceptibility to adolescent anxiety. Our findings deepen the understanding of the neural sensitivity in the developing brain and can inform early identification and personalized interventions for adolescents at risk of anxiety disorders.

The age-related heterogeneity in major depressive disorder (MDD) has received significant attention. However, the neural mechanisms underlying such heterogeneity still need further investigation. This study aimed to explore the common and distinct functional brain abnormalities across different age groups of MDD patients from a large-sample, multicenter analysis.

The analyzed sample consisted of a total of 1238 individuals including 617 MDD patients (108 adolescents, 12–17 years old; 411 early-middle adults, 18–54 years old; and 98 late adults, > = 55 years old) and 621 demographically matched healthy controls (60 adolescents, 449 early-middle adults, and 112 late adults). MDD-related abnormalities in brain functional connectivity (FC) patterns were investigated in each age group separately and using the whole pooled sample, respectively.

We found shared FC reductions among the sensorimotor, visual, and auditory networks across all three age groups of MDD patients. Furthermore, adolescent patients uniquely exhibited increased sensorimotor-subcortical FC; early-middle adult patients uniquely exhibited decreased visual-subcortical FC; and late adult patients uniquely exhibited wide FC reductions within the subcortical, default-mode, cingulo-opercular, and attention networks. Analysis of covariance models using the whole pooled sample further revealed: (1) significant main effects of age group on FCs within most brain networks, suggesting that they are decreased with aging; and (2) a significant age group × MDD diagnosis interaction on FC within the default-mode network, which may be reflective of an accelerated aging-related decline in default-mode FCs.

To summarize, these findings may deepen our understanding of the age-related biological and clinical heterogeneity in MDD.