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The GDF3 gene plays a fundamental role in embryonic morphogenesis. Recent studies have indicated that GDF3 plays a previously unrecognised role in cardiovascular system development. Non-syndromic CHDs might be a clinically isolated manifestation of GDF3 mutations. The purpose of the present study was to identify potential pathological mutations in the GDF3 gene in Chinese children with non-syndromic CHDs, and to gain insight into the aetiology of non-syndromic CHDs.
A total of 200 non-syndromic CHDs patients and 202 normal control patients were sampled. There were two exons of the human GDF3 gene amplified using polymerase chain reaction. The polymerase chain reaction products were purified and directly sequenced.
One missense mutation (c.C635T, p.Ser212 Leu, phenotype: isolated muscular ventricular septal defect) was found that has not been reported previously.
To the best of our knowledge, this is the first study to investigate the role of the GDF3 gene in non-syndromic CHDs. Our results expand the spectrum of mutations associated with CHDs and first suggest the potentially disease-related GDF3 gene variant in the pathogenesis of CHDs.
We found evidence for the super–orbital modulation in the X-ray emission of LS I + 61°303 from the longest monitoring date by the RXTE. The time evolution of the modulated fraction in the orbital light curves can be well fitted with a sinusoidal function having a super-orbital period of 1667 days. However, we have found a 281.8±44.6 day shift between the super-orbital variability found at radio frequencies and our X-ray data. We also find a super-orbital modulation in the maximum count rate of the orbital light curves, compatible with the former results, including the shift.
Sillenite Bi25FeO40 crystallites have been fabricated via a sol-gel approach. X-ray diffraction results show that single-phase Bi25FeO40 can be synthesized at the annealing temperature of 600 oC with the help of PEG additive. The amount of additives and the annealing temperature has great effects on the formation of phase pure Bi25FeO40 crystallites. The morphologies of Bi25FeO40 crystallites were observed by SEM techniques. UV-vis diffuse reflectance spectroscopy indicated the good visible light absorption of Bi25FeO40 crystallites. The photo-catalytic activity of Bi25FeO40 powders was evaluated by the degradation of methyl orange solution assisted by H2O2 under UV-Vis light and Vis-only light irradiation, which suggested that Bi25FeO40 crystallites are potential photocatalytic materials.
Non-destructive Raman spectroscopy was applied to three kinds of porcelain glaze samples: (i) Guan wares of Song Dynasty; (ii) Imitated Guan wares; (Both (i) and (ii) are from the Palace Museum (Beijing, China) collections); (iii) Porcelain shards are collected from the Xiuneisi kiln site which is one of two excavated Guan ware imperial kilns in Hangzhou, the capital of the Southern Song Dynasty. Raman spectra of the glassy phase network were used to discuss the composition and firing temperature of the glaze. The index of polymerization (Ip) is strongly correlated with the firing temperature and the composition of the glaze. According to the Ip values of the glaze, those Guan wares (i) can be classified into three groups. The provenance of Guan wares (i) was discussed by comparing the Ip values to imitations (ii) and shards(iii). The study of classification and provenance are also supported by the X-ray fluorescence data. The Ip values of several recently prepared glazed samples of known firing temperature were measured to build empirical relationship between the Ip value and the firing temperature. Based on the relationship, the firing temperature of the Guan ware glazes was at 1170-1300°C.
A facile hydrothermal route assisted by polyethylene glycol (PEG) 400 was utilized to synthesize single-phase Bi2Fe4O9 crystallites. X-ray diffraction results showed the products with PEG 400 of 30 g/L exhibited a preferred growth along the (001) plane. Transmission electron microscopy indicated that the morphology of the as-prepared Bi2Fe4O9 crystallites with PEG 400 were plake-like and rod-like. Strong absorption in visible-light region of the products was characterized by UV-vis diffuse reflectance spectrum (UV-DRS). The photocatalytic activity of Bi2Fe4O9 crystallites was evaluated on degradation of methyl orange (MO) under visible light irradiation. For 3 h irradiation, the degradation ratio was increased to 93% with the aid of a small amount of H2O2. The analysis of FT-IR spectra proved that the Bi2Fe4O9 catalysts were remained stable after the photocalytic reactions.
A PVA-assisted hydrothermal synthesis route was utilized to fabricate single-phase Bi25FeO40 crystallites.X-ray diffraction results indicated that sillenite Bi25FeO40 have been synthesized at the temperature of 200 ℃ using the KOH concentration of 7 M. Scanning electron microscopy showed the morphology of the as-prepared products were cubic shape with side length of 26μm. The band gap of Bi25FeO40 was determined to be 1.8 eV (688 nm) by using UV-vis diffuse reflectance spectroscopy. It was found that Bi25FeO40 exhibited a high photocatalytic activity for the degradation of methyl orange under UV-Vis irradiation, being a potential material for photocatalytic decomposition of organic contaminants.
Traditional failure modes and effects analysis (FMEA) methods lack sufficient semantics and structure to provide full traceability between the failure modes and the effects of the complex system. To overcome this limitation, this paper proposes a formal failure knowledge representation model combined with the structural decomposition of the complex system. The model defines the failure modes as the inherent properties of the physical entities at different hierarchical levels, and employs the individual color, unified color, and Boolean matrix of the polychromatic sets to represent the failure modes in terms of their interrelationships and their relations to the physical system. This method is a structure-based modeling technique that provides a simple, yet comprehensive framework to organize the failure modes and their causes and effects more systematically and completely. Using the iterative search process operated on the reasoning matrices, the end effects on the entire system can be achieved automatically, which allows for the consideration of both the single and multiple failures. An example is embedded in the description of the methodology for better understanding. Because of the powerful mathematical modeling capability of the polychromatic sets, the approach presented in this paper makes significant progress in FMEA formalization.
Mesostructured lamellar lead sulfide has been synthesized for the first time at room temperature in acidic media, employing sodium dodecyl sulfonate (SDS) as template and soluble lead salts, and hydrated sodium sulfide as the inorganic sources. The material was chiefly characterized by x-ray powder diffraction, high-resolution transmission electron microscopy, Raman spectroscopy, x-ray photoelectron spectroscopy, and thermogravimetric analysis. In the material, the Pb:S molar ratio for the inorganic phase is about 1:1.2, with a distance of about 2.7 nm between the inorganic layers.
To characterize occupationally acquired human immunodeficiency virus (HIV) infection detected through case surveillance efforts in the United States.
National surveillance systems, based on voluntary case reporting.
Healthcare or laboratory (clinical or research) settings.
Healthcare workers, defined as individuals employed in healthcare or laboratory settings (including students and trainees), who are infected with HIV.
Review of data reported through December 2001 in the HIV/AIDS Reporting System and the National Surveillance for Occupationally Acquired HIV Infection.
Of 57 healthcare workers with documented occupationally acquired HIV infection, most (86%) were exposed to blood, and most (88%) had percutaneous injuries. The circumstances varied among 51 percutaneous injuries, with the largest proportion (41%) occurring after a procedure, 35% occurring during a procedure, and 20% occurring during disposal of sharp objects. Unexpected circumstances difficult to anticipate during or after procedures accounted for 20% of all injuries. Of 55 known source patients, most (69%) had acquired immunodeficiency syndrome (AIDS) at the time of occupational exposure, but some (11%) had asymptomatic HIV infection. Eight (14%) of the healthcare workers were infected despite receiving postexposure prophylaxis (PEP).
Prevention strategies for occupationally acquired HIV infection should continue to emphasize avoiding blood exposures. Healthcare workers should be educated about both the benefits and the limitations of PEP, which does not always prevent HIV infection following an exposure. Technologic advances (eg, safety-engineered devices) may further enhance safety in the healthcare workplace
Indexed powder diffraction patterns and related crystallographic data are reported for ErNiSb, which is not represented in the X-ray Powder Diffraction File. The compound ErNiSb is cubic [space group F43m, Z=4, a=6.2693(1) Å]. The R=0.067 indicates that experimental intensities agree well with the calculated patterns.
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