Field studies were conducted at Arlington, WI, in 1996 and 1997 and at Georgetown, DE, and LeSueur, MN, in 1997 to determine weed control efficacy, crop injury, and yield response of PAT-transformed sweet corn to glufosinate-based weed management. Sequential applications of glufosinate 10 to 18 d apart at 0.4 and 0.3 kg ai/ha controlled common lambsquarters, common ragweed, velvetleaf, wild-proso millet, and fall panicum 90% or better at all locations. Weed control varied little among 0.3, 0.4, or 0.3 and 0.3 (sequential) kg/ha glufosinate rates. Glufosinate applied alone, with, or following atrazine controlled velvetleaf 90% or greater but was less consistent on common ragweed and common lambsquarters (73 to 100%). Atrazine plus metolachlor applied preemergence (PRE) and glufosinate applied alone postemergence (POST) provided inconsistent wild-proso millet and fall panicum control (43 to 99%). Metolachlor followed by glufosinate improved consistency of grass control (> 76%). Glufosinate followed by cultivation provided 80% or greater control of velvetleaf and wild-proso millet. Glufosinate did not injure or delay maturity of PAT-transformed sweet corn. Sweet corn treated with glufosinate resulted in yields greater than or equal to the sweet corn that was hand-weeded or received a standard herbicide treatment.