To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Whole-grain cereal breakfast consumption has been associated with beneficial effects on glucose and insulin metabolism as well as satiety. Pearl millet is a popular ancient grain variety that can be grown in hot, dry regions. However, little is known about its health effects. The present study investigated the effect of a pearl millet porridge (PMP) compared with a well-known Scottish oats porridge (SOP) on glycaemic, gastrointestinal, hormonal and appetitive responses. In a randomised, two-way crossover trial, twenty-six healthy participants consumed two isoenergetic/isovolumetric PMP or SOP breakfast meals, served with a drink of water. Blood samples for glucose, insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide (GIP), peptide YY, gastric volumes and appetite ratings were collected 2 h postprandially, followed by an ad libitum meal and food intake records for the remainder of the day. The incremental AUC (iAUC2h) for blood glucose was not significantly different between the porridges (P > 0·05). The iAUC2h for gastric volume was larger for PMP compared with SOP (P = 0·045). The iAUC2h for GIP concentration was significantly lower for PMP compared with SOP (P = 0·001). Other hormones and appetite responses were similar between meals. In conclusion, the present study reports, for the first time, data on glycaemic and physiological responses to a pearl millet breakfast, showing that this ancient grain could represent a sustainable alternative with health-promoting characteristics comparable with oats. GIP is an incretin hormone linked to TAG absorption in adipose tissue; therefore, the lower GIP response for PMP may be an added health benefit.
A 2018 workshop on the White Mountain Apache Tribe lands in Arizona examined ways to enhance investigations into cultural property crime (CPC) through applications of rapidly evolving methods from archaeological science. CPC (also looting, graverobbing) refers to unauthorized damage, removal, or trafficking in materials possessing blends of communal, aesthetic, and scientific values. The Fort Apache workshop integrated four generally partitioned domains of CPC expertise: (1) theories of perpetrators’ motivations and methods; (2) recommended practice in sustaining public and community opposition to CPC; (3) tactics and strategies for documenting, investigating, and prosecuting CPC; and (4) forensic sedimentology—uses of biophysical sciences to link sediments from implicated persons and objects to crime scenes. Forensic sedimentology served as the touchstone for dialogues among experts in criminology, archaeological sciences, law enforcement, and heritage stewardship. Field visits to CPC crime scenes and workshop deliberations identified pathways toward integrating CPC theory and practice with forensic sedimentology’s potent battery of analytic methods.
Although food from grazed animals is increasingly sought by consumers because of perceived animal welfare advantages, grazing systems provide the farmer and the animal with unique challenges. The system is dependent almost daily on the climate for feed supply, with the importation of large amounts of feed from off farm, and associated labour and mechanisation costs, sometimes reducing economic viability. Furthermore, the cow may have to walk long distances and be able to harvest feed efficiently in a highly competitive environment because of the need for high levels of pasture utilisation. She must, also, be: (1) highly fertile, with a requirement for pregnancy within ~80 days post-calving; (2) ‘easy care’, because of the need for the management of large herds with limited labour; (3) able to walk long distances; and (4) robust to changes in feed supply and quality, so that short-term nutritional insults do not unduly influence her production and reproduction cycles. These are very different and are in addition to demands placed on cows in housed systems offered pre-made mixed rations. Furthermore, additional demands in environmental sustainability and animal welfare, in conjunction with the need for greater system-level biological efficiency (i.e. ‘sustainable intensification’), will add to the ‘robustness’ requirements of cows in the future. Increasingly, there is evidence that certain genotypes of cows perform better or worse in grazing systems, indicating a genotype×environment interaction. This has led to the development of tailored breeding objectives within countries for important heritable traits to maximise the profitability and sustainability of their production system. To date, these breeding objectives have focussed on the more easily measured traits and those of highest relative economic importance. In the future, there will be greater emphasis on more difficult to measure traits that are important to the quality of life of the animal in each production system and to reduce the system’s environmental footprint.
The occurrence of secondary flows is investigated for three-dimensional sinusoidal roughness where the wavelength and height of the roughness elements are systematically altered. The flow spanned from the transitionally rough regime up to the fully rough regime and the solidity of the roughness ranged from a wavy, sparse roughness to a dense roughness. Analysing the time-averaged velocity, secondary flows are observed in all of the cases, reflected in the coherent stress profile which is dominant in the vicinity of the roughness elements. The roughness sublayer, defined as the region where the coherent stress is non-zero, scales with the roughness wavelength when the roughness is geometrically scaled (proportional increase in both roughness height and wavelength) and when the wavelength increases at fixed roughness height. Premultiplied energy spectra of the streamwise velocity turbulent fluctuations show that energy is reorganised from the largest streamwise wavelengths to the shorter streamwise wavelengths. The peaks in the premultiplied spectra at the streamwise and spanwise wavelengths are correlated with the roughness wavelength in the fully rough regime. Current simulations show that the spanwise scale of roughness determines the occurrence of large-scale secondary flows.
Introduction: Understanding the spatial distribution of opioid abuse at the local level may facilitate community intervention strategies. The purpose of this analysis was to apply spatial analytical methods to determine clustering of opioid-related emergency medical services (EMS) responses in the City of Calgary. Methods: Using opioid-related EMS responses in the City of Calgary between January 1st through October 31st, 2017, we estimated the dissemination area (DA) specific spatial randomness effects by incorporating the spatial autocorrelation using intrinsic Gaussian conditional autoregressive model and generalized linear mixed models (GLMM). Global spatial autocorrelation was evaluated by Morans I index. Both Getis-Ord Gi and the LISA function in Geoda were used to estimate the local spatial autocorrelation. Two models were applied: 1) Poisson regression with DA-specific non-spatial random effects; 2) Poisson regression with DA-specific G-side spatial random effects. A pseudolikelihood approach was used for model comparison. Two types of cluster analysis were used to identify the spatial clustering. Results: There were 1488 opioid-related EMS responses available for analysis. Of the responses, 74% of the individuals were males. The median age was 33 years ( IQR: 26-42 years) with 65% of individuals between 20 and 39 years, and 27% between 40 and 64 years. In 62% of EMS responses, poisoning/overdose was the chief complaint. The global Morans Index implied the presence of global spatial autocorrelation. Comparing the two models applied suggested that the spatial model provided a better fit for the adjusted opioid-related EMS response rate. Calgary Center and East were identified as hot spots by both types of cluster analysis. Conclusion: Spatial modeling has a better predictability to assess potential high risk areas and identify locations for community intervention strategies. The clusters identified in Calgarys Center and East may have implications for future response strategies.
Broadleaf species escape current integrated weed management strategies in strawberry [Fragaria×ananassa (Weston) Duchesne ex Rozier (pro sp.) [chiloensis×virginiana]] production. Clopyralid is a registered POST control option, but current application timings provide suppression of only some species. Earlier clopyralid application timings may increase spray coverage to weeds at the planting hole, but strawberry plant tolerance to applications shortly after transplant is unknown. The objectives of the study were to determine the degree of clopyralid tolerance when applied to mature strawberry plants according to current management strategies, whether clopyralid absorption and translocation were involved in the tolerance response demonstrated by mature strawberry plants, and whether clopyralid could be safely applied to immature strawberry plants shortly after transplant. Clopyralid caused no damage when applied to mature strawberry plants and did not affect crop height, number of crowns, flowers, immature berries, or yield. Maximal strawberry absorption of radiolabeled clopyralid was 82% of the recovered radioactivity and reached peak (90%) absorption at 15 h. Maximal total translocation of radioactivity from the treated leaf was 17% and reached peak translocation at 52 h. Translocation was primarily to the new leaves and reproductive structures. In the early-application experiment, damage induced by clopyralid for all application timings reached 0 by 8 wk after treatment. Across all timings, maximal damage at 140 g ha−1 was 17% when applied 14 d after transplant (DATr) and 56% at 28 g ha−1 when applied at 21 DATr. Clopyralid dose did not affect the number of crowns, aboveground biomass, or yield. There was some stunting in plant height (3%) by the high labeled dose of clopyralid. Labeled dose clopyralid applications appear safe for application timings closer to strawberry transplant, though considerations of leaf cupping should be taken under consideration for label changes.
Strawberry is an important horticultural crop in Florida. The long growing season and escapes from fumigation and PRE herbicides necessitate POST weed management to maximize harvest potential and efficiency. Alternatives to hand-weeding are desirable, but clopyralid is the only broadleaf herbicide registered for use. Weed control may be improved by early-season clopyralid applications, but at risk of high temperature and increased strawberry injury. The effect of temperature on clopyralid safety on strawberry is unknown. We undertook a growth chamber experiment using a completely randomized design to determine crop safety under various temperature conditions across acclimation, herbicide application, and post-application periods. There was no effect of clopyralid on the number of strawberry leaves across all temperatures. Damage to the strawberry manifested as leaf malformations. Acclimation temperatures affected clopyralid-associated injury (p=0.0309), with increased leaf malformations at higher temperatures (27 C) compared to lower (18 C) temperatures. Pre-treatment temperatures did not affect clopyralid injury. Post-application temperature also affected clopyralid injury (p=0.0161), with increased leaf malformations at higher temperatures compared to lower ones. Clopyralid application did not reduce flowering or biomass production in the growth chamber. If leaf malformations are to be avoided, consideration to growing conditions prior to application is advisable, especially if applying clopyralid early in the season.
Strawberries, an important Florida crop, are grown on raised beds covered with plastic mulch. The plastic mulch provides good control of many weeds, but some problem species can emerge from the transplant hole during crop establishment. POST herbicide options for broadleaf weed control within the strawberry bed is limited to clopyralid, which only provides suppression. Strawberry canopy shielding may be responsible for the observed incomplete control with clopyralid application for problematic broadleaf weed species such as black medic and Carolina geranium. Two field experiments were established on mature strawberries to evaluate spray penetration through the canopy. The first examined spray penetration through the canopy of multiple strawberry cultivars at various distances from the crown. The second examined the effects of application volumes and nozzle selection on spray penetration. Cultivar selection had no effect on spray penetration through the canopy. In the first study, when applying at 281 L ha−1, the area around the planting hole (0 to 5 cm from the crown) had 8% coverage below the canopy while the area below the canopy edge (10 to 15 cm from the crown) had 27% coverage. In the second study, increasing the application volume from 187 to 375 L ha−1 increased coverage by 81%. Increasing the application volume from 375 to 740 L ha−1 increased coverage 33% with maximal coverage of 53% at 740 L ha−1. Nozzle type (standard even flat spray tip, Drift Guard, or TwinJet nozzles) did not affect coverage or deposition volume below the canopy. Overall, mature strawberry canopies demonstrated similar spray droplet penetration across cultivars with increased penetration with increased distance from the crown. Penetration increased with increasing application volume, but the nozzle types used in this experiment did not affect penetration. Additional research is needed to better define the effect of application volume on herbicide efficacy.
Strawberries are an important horticultural crop in Florida. Black medic is among the most problematic weeds within the production system. To better coordinate control measures, black medic growth and development while in competition with strawberry was studied. Twelve plants were randomly selected at each of four field sites in Hillsborough County, FL, in 2014. Plants were repeatedly measured over the growing season for stem length and number of primary branches, flower buds, flowers, and seed clusters. Growing degree days (GDD) were calculated (Tbase=0 C) starting from the hole-punch application of the plastic mulch (October 8, 2014, to October 10, 2014) from weather station data generated from the Florida Automated Weather Network. Strawberry height and width increased consistently across all sites, but black medic growth and development varied considerably. Strawberry suppressed black medic growth up to 1,805 cumulative GDD at three of four sites where black medic remained beneath the strawberry canopy. After 1,805 GDD, the black medic stems still remained below but experienced exponential growth for total stem length and, in turn, flower buds, inflorescence, and immature seed clusters. Ideal clopyralid spray timing based on susceptible plant size was 890 to 1,152 GDD. Optimal hand-weeding time frames would likely occur as the plant stems expand beyond the strawberry canopy (to improve visibility) and before flower production to prevent seed return to the seedbank. First seed production was observed at 1,200 GDD at the earliest site and between 1,966 to 2,365 GDD across all the other sites. Overall, consistent trends were observed across sites, but between-site variability was observed that could not be accounted for by differences in temperature.
Roughness predominantly alters the near-wall region of turbulent flow while the outer layer remains similar with respect to the wall shear stress. This makes it a prime candidate for the minimal-span channel, which only captures the near-wall flow by restricting the spanwise channel width to be of the order of a few hundred viscous units. Recently, Chung et al. (J. Fluid Mech., vol. 773, 2015, pp. 418–431) showed that a minimal-span channel can accurately characterise the hydraulic behaviour of roughness. Following this, we aim to investigate the fundamental dynamics of the minimal-span channel framework with an eye towards further improving performance. The streamwise domain length of the channel is investigated with the minimum length found to be three times the spanwise width or 1000 viscous units, whichever is longer. The outer layer of the minimal channel is inherently unphysical and as such alterations to it can be performed so long as the near-wall flow, which is the same as in a full-span channel, remains unchanged. Firstly, a half-height (open) channel with slip wall is shown to reproduce the near-wall behaviour seen in a standard channel, but with half the number of grid points. Next, a forcing model is introduced into the outer layer of a half-height channel. This reduces the high streamwise velocity associated with the minimal channel and allows for a larger computational time step. Finally, an investigation is conducted to see if varying the roughness Reynolds number with time is a feasible method for obtaining the full hydraulic behaviour of a rough surface. Currently, multiple steady simulations at fixed roughness Reynolds numbers are needed to obtain this behaviour. The results indicate that the non-dimensional pressure gradient parameter must be kept below 0.03–0.07 to ensure that pressure gradient effects do not lead to an inaccurate roughness function. An empirical costing argument is developed to determine the cost in terms of CPU hours of minimal-span channel simulations a priori. This argument involves counting the number of eddy lifespans in the channel, which is then related to the statistical uncertainty of the streamwise velocity. For a given statistical uncertainty in the roughness function, this can then be used to determine the simulation run time. Following this, a finite-volume code with a body-fitted grid is used to determine the roughness function for square-based pyramids using the above insights. Comparisons to experimental studies for the same roughness geometry are made and good agreement is observed.
Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major aetiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis, irritable bowel syndrome and inflammatory bowel disease. The notion that specific probiotic bacterial strains can affect barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are used to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues and categorises the lines of evidence available in literature for the role of probiotics in epithelial integrity and, consequently, their beneficial effect for the reduction of gastrointestinal disease symptoms.
We investigate rough-wall turbulent flows through direct numerical simulations of flow over three-dimensional transitionally rough sinusoidal surfaces. The roughness Reynolds number is fixed at
is the sinusoidal semi-amplitude, and the sinusoidal wavelength is varied, resulting in the roughness solidity
(frontal area divided by plan area) ranging from 0.05 to 0.54. The high cost of resolving both the flow around the dense roughness elements and the bulk flow is circumvented by the use of the minimal-span channel technique, recently demonstrated by Chung et al. (J. Fluid Mech., vol. 773, 2015, pp. 418–431) to accurately determine the Hama roughness function,
. Good agreement of the second-order statistics in the near-wall roughness-affected region between minimal- and full-span rough-wall channels is observed. In the sparse regime of roughness (
) the roughness function increases with increasing solidity, while in the dense regime the roughness function decreases with increasing solidity. It was found that the dense regime begins when
, in agreement with the literature. A model is proposed for the limit of
, which is a smooth wall located at the crest of the roughness elements. This model assists with interpreting the asymptotic behaviour of the roughness, and the rough-wall data presented in this paper show that the near-wall flow is tending towards this modelled limit. The peak streamwise turbulence intensity, which is associated with the turbulent near-wall cycle, is seen to move further away from the wall with increasing solidity. In the sparse regime, increasing
reduces the streamwise turbulent energy associated with the near-wall cycle, while increasing
in the dense regime increases turbulent energy. An analysis of the difference of the integrated mean momentum balance between smooth- and rough-wall flows reveals that the roughness function decreases in the dense regime due to a reduction in the Reynolds shear stress. This is predominantly due to the near-wall cycle being pushed away from the roughness elements, which leads to a reduction in turbulent energy in the region previously occupied by these events.
Previous neuroimaging studies indicate abnormalities in cortico-limbic circuitry in mood disorder. Here we employ prospective longitudinal voxel-based morphometry to examine the trajectory of these abnormalities during early stages of illness development.
Unaffected individuals (16–25 years) at high and low familial risk of mood disorder underwent structural brain imaging on two occasions 2 years apart. Further clinical assessment was conducted 2 years after the second scan (time 3). Clinical outcome data at time 3 was used to categorize individuals: (i) healthy controls (‘low risk’, n = 48); (ii) high-risk individuals who remained well (HR well, n = 53); and (iii) high-risk individuals who developed a major depressive disorder (HR MDD, n = 30). Groups were compared using longitudinal voxel-based morphometry. We also examined whether progress to illness was associated with changes in other potential risk markers (personality traits, symptoms scores and baseline measures of childhood trauma), and whether any changes in brain structure could be indexed using these measures.
Significant decreases in right amygdala grey matter were found in HR MDD v. controls (p = 0.001) and v. HR well (p = 0.005). This structural change was not related to measures of childhood trauma, symptom severity or measures of sub-diagnostic anxiety, neuroticism or extraversion, although cross-sectionally these measures significantly differentiated the groups at baseline.
These longitudinal findings implicate structural amygdala changes in the neurobiology of mood disorder. They also provide a potential biomarker for risk stratification capturing additional information beyond clinically ascertained measures.
Smutgrass, a native of tropical Asia, is a perennial weed that affects many improved perennial grass pastures in Florida and throughout the southeastern United States. The two varieties of smutgrass predominant in Florida are small smutgrass and giant smutgrass. Three field experiments were conducted from 2008 to 2012 to evaluate the effect of integrated long-term management strategies using both cultural and herbicide inputs for giant smutgrass control in bahiagrass pastures. Burning did not have a significant impact on long-term control. In 2011, no differences were observed when hexazinone was integrated with tillage or hexazinone was combined with supplemental nitrogen compared with sequential or single applications of hexazinone. However, cultural treatments that preceded hexazinone application compared with those that received two sequential applications of hexazinone had lower smutgrass control 36 mo after treatment. Data indicate that a sequential application of hexazinone may be better than implementing tillage. Sequential hexazinone applications, when applied at 0.56 kg ai ha−1 or greater, resulted in similar or increased control as compared with single applications. Collectively, these data suggest that sequential applications of hexazinone may be most effective for smutgrass management, and cultural techniques, including tillage, should be followed by hexazinone application the following year.
We describe a fast direct numerical simulation (DNS) method that promises to directly characterise the hydraulic roughness of any given rough surface, from the hydraulically smooth to the fully rough regime. The method circumvents the unfavourable computational cost associated with simulating high-Reynolds-number flows by employing minimal-span channels (Jiménez & Moin, J. Fluid Mech., vol. 225, 1991, pp. 213–240). Proof-of-concept simulations demonstrate that flows in minimal-span channels are sufficient for capturing the downward velocity shift, that is, the Hama roughness function, predicted by flows in full-span channels. We consider two sets of simulations, first with modelled roughness imposed by body forces, and second with explicit roughness described by roughness-conforming grids. Owing to the minimal cost, we are able to conduct direct numerical simulations with increasing roughness Reynolds numbers while maintaining a fixed blockage ratio, as is typical in full-scale applications. The present method promises a practical, fast and accurate tool for characterising hydraulic resistance directly from profilometry data of rough surfaces.
Direct numerical simulations (DNS) are conducted for turbulent flow through pipes with three-dimensional sinusoidal roughnesses explicitly represented by body-conforming grids. The same viscous-scaled roughness geometry is first simulated at a range of different Reynolds numbers to investigate the effects of low Reynolds numbers and low
is the pipe radius and
is the roughness height. Results for the present class of surfaces show that the Hama roughness function
is only marginally affected by low Reynolds numbers (or low
), and observations of outer-layer similarity (or lack thereof) show no signs of sensitivity to Reynolds number. Then, building on this, a systematic approach is taken to isolate the effects of roughness height
in a turbulent wall-bounded flow in both transitionally rough and fully rough regimes. Current findings show that while the effective slope
(which for the present sinusoidal surfaces is proportional to
) is an important roughness parameter, the roughness function
must also depend on some measure of the viscous roughness height. A simplistic linear–log fit clearly illustrates the strong correlation between
and both the roughness average height
(which is related to
for the surfaces simulated here, consistent with published literature. Various definitions of the virtual origin for rough-wall turbulent pipe flow are investigated and, for the surfaces simulated here, the hydraulic radius of the pipe appears to be the most suitable parameter, and indeed is the only virtual origin that can ever lead to collapse in the total stress. First- and second-order statistics are also analysed and collapses in the outer layer are observed for all cases, including those where the largest roughness height is a substantial proportion of the reference radius (low
). These results provide evidence that turbulent pipe flow over the present sinusoidal surfaces adheres to Townsend’s notion of outer-layer similarity, which pertains to statistics of relative motion.
Background: Controlled qualitative methods complement quantitative treatment outcome research and enable a more thorough understanding of the effects of therapy and the suspected mechanisms of action. Aims: Thematic analyses were used to examine outcomes of cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) in a randomized controlled trial of individuals diagnosed with military-related PTSD (n = 15). Method: After sessions 1 and 11, participants wrote “impact statements” describing their appraisals of their trauma and beliefs potentially impacted by traumatic events. Trained raters coded each of these statements using a thematic coding scheme. Results: An analysis of thematic coding revealed positive changes over the course of therapy in participants’ perspective on their trauma and their future, supporting the purported mechanisms of CPT. Conclusion: Implications of this research for theory and clinical practice are discussed.