Powder X-ray diffraction patterns for three forms of MIL-53(Al), a metal organic framework (MOF) compound with breathing characteristics, were investigated using the Rietveld refinement method. These three samples are referred to as the MIL-53(Al)as-syn (the as synthesized sample), orthorhombic, Pnma, a = 17.064(2) Å, b = 6.6069(9) Å, c = 12.1636(13) Å, V = 1371.3(2) Å3, Z = 4), MIL-53(Al)LT-H (low-temperature hydrated phase, monoclinic P21/c, a = 19.4993(8) Å, b = 15.2347(6) Å, c = 6.5687(3) Å, β = 104.219(4) °, V = 1891.55(10) Å3, Z = 8), and MIL-53(Al)HT-D (high-temperature dehydrated phase, Imma, a = 6.6324(5) Å, b = 16.736(2) Å, c = 12.840(2), V = 1425.2(2) Å3, Z = 4). The crystal structures of the “as-syn” sample and the HT-D sample are confirmed to be the commonly adopted ones. However, the structure of the MIL-53(Al)LT-H phase is confirmed to be monoclinic with a space group of P21/c instead of the commonly accepted space group Cc, resulting in a cell volume double in size. The structure has two slightly different types of channel. The pore volumes and pore surface area were estimated to be 0.11766 (8) cm3/g and 1461.3(10) m2/g for MIL-53(Al)HT-D (high-temperature dehydrated phase), and 0.08628 (5) cm3/g and 1401.6 (10) m2/g for MIL-53(Al)as-syn phases, respectively. The powder patterns for the MIL-53(Al)as-syn and MIL-53(Al)HT-D phases are reported in this paper.

Global inequity in access to and availability of essential mental health services is well recognized. The mental health treatment gap is approximately 50% in all countries, with up to 90% of people in the lowest-income countries lacking access to required mental health services. Increased investment in global mental health (GMH) has increased innovation in mental health service delivery in LMICs. Situational analyses in areas where mental health services and systems are poorly developed and resourced are essential when planning for research and implementation, however, little guidance is available to inform methodological approaches to conducting these types of studies. This scoping review provides an analysis of methodological approaches to situational analysis in GMH, including an assessment of the extent to which situational analyses include equity in study designs. It is intended as a resource that identifies current gaps and areas for future development in GMH. Formative research, including situational analysis, is an essential first step in conducting robust implementation research, an essential area of study in GMH that will help to promote improved availability of, access to and reach of mental health services for people living with mental illness in low- and middle-income countries (LMICs). While strong leadership in this field exists, there remain significant opportunities for enhanced research representing different LMICs and regions.

Background: Challenges in predicting risk of recurrence for individual patients with meningioma limits appropriate selection of patients who may benefit from adjuvant radiation therapy to delay recurrence. Here, we aimed to develop and validate a combined clinicomolecular predictor of early recurrence for individual patients with meningiomas. Methods: A methylation-based predictor of 5-year recurrence-free-survival (RFS) was developed using DNA-methylation profiles from a training cohort of 228 patients. Model performance was compared to a standard-of-care histological-based model using three independent cohorts (N=54 ;N=140; N=64 patients). Subsequently, a nomogram that integrated the methylome-based predictor with prognostic clinical factors was developed and validated. Results: The methylome-based predictor of 5-year RFS performed favorably compared to a grade-based predictor when tested using the three validation cohorts (ΔAUC=0.10, 95%CI 0.03 – 0.018) and was independently associated with RFS on multivariable Cox regression analysis (HR=3.6, 95%CI 1.8–7.2, P<0.001). A nomogram combining the methylome-predictor with clinical factors demonstrated greater discrimination for recurrence than a nomogram using clinical factors alone (ΔAUC=0.25, 95%CI 0.22–0.27) and resulted in two risk groups with distinct recurrence patterns (HR=7.7, 95%CI 5.3–11.1, P<0.001) and clinical implications. Conclusions: Our validated models provide important novel prognostic information that could be used to individualize decisions regarding post-operative therapeutic interventions in meningioma.

Ten compounds are found in the Ba0-Y203-CuOx system. High temperature (≈950-1000°C) phases identified as Ba4Y2O7 , Ba2Y2O5 , Ba3Y4O9 , BaY2O4 , Y2Cu2O5 , BaCuO2+x, Ba3YCu2OZ BaY2Cu05 and BazYCu306+x are formed in this temperature range. In addition, a new compound with composition of 2BaO:CuO, which possibly has a melting point below 950°C, was prepared at 850°C. A summary o£ the crystallographic data of these 10 phases is given. In particular, results of x-ray studies pertaining to four compounds, BazYCu306+x, which is currently the most promising high To' superconductor material, Ba2Cu03 , BaY2Cu05 , and Ba3YCu20Z are reviewed.

Based on the experimentally determined framework structure of porous MnO2 octahedral molecular sieve (OMS)-5, we used density functional theory-based calculations to evaluate the effect of Na+ cation on pore dimensionality and structural stability, and the interaction between CO2 and OMS-5. We quantified the formation energy of one CO2/unit tunnel and two CO2/unit tunnel, and projected the electronic density of states on the OMS-5 framework, CO2 molecules, and Na+ cations to reveal their individual contributions and bonding nature. Partial charge densities were also calculated to investigate CO2 adsorption behavior in the OMS-5. Our studies predict the initial stage and driving force for the adsorption of CO2 in the OMS-5, guiding the OMS material design for carbon capture and storage applications.

A series of double-perovskite oxides, Sr2RNbO6 (R = Sm, Gd, Dy, Ho, Y, Tm, and Lu) were prepared and their crystal structure and powder diffraction reference patterns were determined using the Rietveld analysis technique. The crystal structure of each of the Sr2RNbO6 phase is reported in this paper. The R = Gd, Ho, and Lu samples were studied using synchrotron radiation, while R = Sm, Dy, Y, and Tm samples were studied using laboratory X-ray diffraction. Members of Sr2RNbO6 are monoclinic with a space group of P21/n and are isostructural with each other. Following the trend of “lanthanide contraction”, from R = Sm to Lu, the lattice parameters “a” of these compounds decreases from 5.84672(10) to 5.78100(3) Å, b from 5.93192(13) to 5.80977(3) Å, c from 8.3142(2) to 8.18957(5) Å, and V decreases from 288.355(11) to 275.057(2) Å3. In this double-perovskite series, the R3+ and Nb5+ ions are structurally ordered. The average Nb–O bond length is nearly constant, while the average R–O bond length decreases with the decreasing ionic radius of R3+. Powder diffraction patterns for these compounds have been submitted to the Powder Diffraction File (PDF).

Pressure-driven laminar and turbulent flow in a horizontal partially filled pipe was investigated using stereoscopic particle imaging velocimetry (S-PIV) in the cross-stream plane. Laminar flow velocity measurements are in excellent agreement with a recent theoretical solution in the literature. For turbulent flow, the flow depth was varied independently of a nominally constant Reynolds number (based on hydraulic diameter, $D_{H}$ ; bulk velocity, $U_{b}$ and kinematic viscosity $\unicode[STIX]{x1D708}$ ) of $Re_{H}=U_{b}D_{H}/\unicode[STIX]{x1D708}\approx 30\,000\pm 5\,\%$ . When running partially full, the inferred friction factor is no longer a simple function of Reynolds number, but also depends on the Froude number $Fr=U_{b}/\sqrt{gD_{m}}$ where $g$ is gravitational acceleration and $D_{m}$ is hydraulic mean depth. S-PIV measurements in turbulent flow reveal the presence of secondary currents which causes the maximum streamwise velocity to occur below the free surface consistent with results reported in the literature for rectangular cross-section open channel flows. Unlike square duct and rectangular open channel flow the mean secondary motion observed here manifests only as a single pair of vortices mirrored about the vertical bisector and these rollers, which fill the half-width of the pipe, remain at a constant distance from the free surface even with decreasing flow depth for the range of depths tested. Spatial distributions of streamwise Reynolds normal stress and turbulent kinetic energy exhibit preferential arrangement rather than having the same profile around the azimuth of the pipe as in a full pipe flow. Instantaneous fields reveal the signatures of elements of canonical wall-bounded turbulent flows near the pipe wall such as large-scale and very-large-scale motions and associated hairpin packets whilst near the free surface, the signatures of free surface turbulence in the absence of imposed mean shear such as ‘upwellings’, ‘downdrafts’ and ‘whirlpools’ are present. Two-point spatio-temporal correlations of streamwise velocity fluctuation suggest that the large-scale coherent motions present in full pipe flow persist in partially filled pipes but are compressed and distorted by the presence of the free surface and mean secondary motion.

The archaeology of the nineteenth-century Chinese diaspora is a well-developed archaeological subfield, but research on Chinese migrants’ homelands is lacking. Survey of a qiaoxiang (home village) in China's Pearl River Delta provides the first archaeological evidence from a home village of Chinese migrants. Transnational comparative analysis with collections recovered from Chinese diaspora settlements reveals stark differences in the use of China-produced goods between qiaoxiang and Chinese settlements abroad. Qiaoxiang residents primarily used locally produced ceramics, while residents of Chinese diaspora settlements consumed ceramics produced in Gaobei and Jingdezhen, major pottery centers located in northeast Guangdong Province and Jiangxi Province, hundreds of kilometers to the north. Additionally, qiaoxiang residents were engaged in global networks of consumption, using British refined earthenwares and other products produced in Europe and the United States. These findings challenge the common assumption made in diaspora research that artifacts produced in migrants’ homelands are evidence of tradition, while those produced in migrants’ adopted countries are evidence of culture change. Instead, the results of qiaoxiang archaeology indicate the significance of nonstate actors, especially import-export companies, in shaping the material worlds of both homeland and diaspora communities. (Spanish abstract available as Supplemental Text 1.)

The Binary Population and Spectral Synthesis suite of binary stellar evolution models and synthetic stellar populations provides a framework for the physically motivated analysis of both the integrated light from distant stellar populations and the detailed properties of those nearby. We present a new version 2.1 data release of these models, detailing the methodology by which Binary Population and Spectral Synthesis incorporates binary mass transfer and its effect on stellar evolution pathways, as well as the construction of simple stellar populations. We demonstrate key tests of the latest Binary Population and Spectral Synthesis model suite demonstrating its ability to reproduce the colours and derived properties of resolved stellar populations, including well-constrained eclipsing binaries. We consider observational constraints on the ratio of massive star types and the distribution of stellar remnant masses. We describe the identification of supernova progenitors in our models, and demonstrate a good agreement to the properties of observed progenitors. We also test our models against photometric and spectroscopic observations of unresolved stellar populations, both in the local and distant Universe, finding that binary models provide a self-consistent explanation for observed galaxy properties across a broad redshift range. Finally, we carefully describe the limitations of our models, and areas where we expect to see significant improvement in future versions.

Classical theories of channelized subglacial drainage identify a melting vs creep balance at the channel-ice boundary that is crucial in determining its steady flow properties, but this consideration neglects the role of erodible-deformable basal sediments, especially in controlling channel morphology. Here we present a mathematical model for channel/underneath ice sheets, which incorporates the detailed mechanics of sediment transport over a mobile till-bed interface, and which allows a variable, wide channel cross section also. The resulting drainage conditions depend on the sediment flux (q) as well as the water flux (Q) through the channel - these quantities being controlled by the rates at which sediment and meltwater are captured by the flow. An approximate analytical solution indicates a "canal"-type drainage law (Walder and Fowler, 1994) of the form where N2 is thε effective channel pτessUτe, n is the exponent in Glen’s flow law for ice, and Ψ is the imposed hydraulic gradient (due to topography). By solving the downstream problem numerically, the canal characteristic has been confirmed and found to be insensitive to upstream conditions. Thus, low effective pressures can result from high basal water flux or melt rates. This supports the contention that canals may be a central component in fast ice flow over soft beds The proposed model also establishes a fundamental link between the plumbing system of a glacier and its sediment budget.

To characterize contacts in general wards, a prospective survey of healthcare workers (HCWs), patients and visitors was conducted using self-reported diary, direct observation and telephone interviews. Nurses, doctors and assorted HCWs reported a median of 14, 18 and 15 contact persons over one work shift, respectively. Within 1 h, we observed 3·5 episodes with 25·6 min of cumulative contact time for nurses, 2·9 episodes and 22·1 min for doctors and 5·0 episodes with 44·3 min for assorted-HCWs. In interactions with patients, nurses had multiple brief episodes of contact; doctors had fewer episodes and less cumulative contact time; assorted-HCWs had fewer contact episodes of longer durations (than for nurses and doctors). Assortative mixing occurred amongst HCWs: those of the same HCW type were the next most frequent class of contact after patients. Over 24-h, patients contacted 14 persons with 23 episodes and 314·5 min of contact time. Patient-to-patient contact episodes were rare, but a maximum of five were documented from one patient participant. 22·9% of visitors reported contact with patients other than the one they visited. Our study revealed differences in the characteristics of contacts among different HCW types and potential transmission routes from patients to others within the ward environment.

Bakaninbreen in Svalbard and Trapridge Glacier in Yukon Territory, Canada, are two prominent examples of surging glaciers which are thought to be controlled by their thermal regime. Both glaciers have developed large bulges which have propagated forward as travelling wave fronts, and which are thought to divide relatively stagnant downstream cold-based ice from faster-moving warm-based upstream ice. Additionally, both glaciers are underlain by a wet, metres thick layer of deforming till. We develop a simple model for the cyclic surging behaviour of these glaciers, which interrelates the motion of the ice and till through a description of the subglacial hydrology. We find that oscillations (surges) can occur if the subglacial hydrological transmissivity is sufficiently low and the till layer is sufficiently thin, and we suggest that these oscillations are associated with the development and propagation of a travelling wave front down the glacier. We therefore interpret the travelling wave fronts on both Trapridge Glacier and Bakaninbreen as manifestations of surges. In addition, we find that the violence of the surge in the model is associated with the resistance to ice flow offered by undulations in the bed, and the efficiency with which occasional hydrological events can release water accumulated at the glacier sole.

Previous models of ice–till deformation near subglacial channels or cavities neglect the fact that the motions of the two materials are coupled, and thus the interface between ice and till may not remain stationary. Here, we analyze in succession two models which address the effect of such coupling via specification of appropriate continuity conditions for stress and velocity across the interface. The modelled scenario is that of a shallow channel–cavity, with its long axis parallel to the principal ice-flow direction, overlying actively deforming till sediments. By applying asymptotic techniques, we investigate how the pattern and velocity of the creep flow depend generally on the ratio between the ice and till viscosities, and on the deforming-till thickness. A more sophisticated, non-linear rheology for till sediments is then introduced. It reveals that the two-way interaction between water percolation and deformation in the till will enhance the localization of sediment flow near the channel margins. The length scale over which transition of effective stress in the till takes place — from its relatively high, far-field value to the low, channel value — is found to depend critically on a dimensionless permeability parameter (Λ). In any case, coupled deformation causes sediment (and ice) flow towards the channel, subsidence of the ice–till interface just outside the channel, and extension of the area over which the ice is in contact with till. Apart from having direct implications for subglacial sediment transport, these results indicate that coupled deformation can contribute significantly to the spatial evolution of stress distribution under a glacier, and thus its incorporation into future sliding and drainage theories for a soft bed should be considered essential.