The pulsed nature of the irradiation and the high neutron dose are the critical factors in an Inertial Fusion Energy reactor (IFE). The damage that structural materials suffer under these extremes conditions require a careful study and assessment. The goal of our work is to simulate, trough the multiscale modelling approach, the damage accumulation in μ-Fe under conditions relevant to a IFE Reactor. We discuss how the pulse frequency, 1 Hz, 10 Hz, and the dose rate of 10 ⊏2 and 10 ⊏1 dpa/s affect the damage production and accumulation. Results of the damage that this demanding environment can produce on a protected first structural exposed to 150 keV average recoil ion will be presented. A further comparison it has been made with the damage produced by a continuous irradiation at similar average dose.