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The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural–geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.
We study single-phase and particle-laden turbulent channel flows bounded by two incompressible hyper-elastic walls with different deformability at bulk Reynolds number
. The solid volume fraction of finite-size neutrally buoyant rigid spherical particles considered is
. The elastic walls are assumed to be of a neo-Hookean material. A fully Eulerian formulation is employed to model the elastic walls together with a direct-forcing immersed boundary method for the coupling between the fluid and the particles. The data show a significant drag increase and the enhancement of the turbulence activity with growing wall elasticity for both the single-phase and particle-laden flows when compared with the single-phase flow over rigid walls. Drag reduction and turbulence attenuation is obtained, on the other hand, with highly elastic walls when comparing the particle-laden flow with the single-phase flow for the same wall properties; the opposite effect, drag increase, is observed upon adding particles to the flow over less elastic walls. This is explained by investigating the near-wall turbulence, where the strong asymmetry in the magnitude of the wall-normal velocity fluctuations (favouring positive
), is found to push the particles towards the channel centre. The particle layer close to the wall contributes to turbulence production by increasing the wall-normal velocity fluctuations, so that in the absence of this layer, smaller wall deformations and in turn turbulence attenuation is observed. For a moderate wall elasticity, we increase the particle volume fraction up to
and find that particle migration away from the wall is the cause of turbulence attenuation with respect to the flow over rigid walls. However, for this higher volume fractions, the particle induced stress compensates for the decreasing Reynolds shear stress, resulting in a higher overall drag for the case with elastic walls. The effect of the wall elasticity on the overall drag reduces significantly with increasing particle volume fraction.
We present a study of Lagrangian intermittency and its characteristic time scales. Using the concepts of flying and diving residence times above and below a given threshold in the magnitude of turbulence quantities, we infer the time spectra of the Lagrangian temporal fluctuations of dissipation, acceleration and enstrophy by means of a direct numerical simulation in homogeneous and isotropic turbulence. We then relate these time scales, first, to the presence of extreme events in turbulence and, second, to the local flow characteristics. Analyses confirm the existence in turbulent quantities of holes mirroring bursts, both of which are at the core of what constitutes Lagrangian intermittency. It is shown that holes are associated with quiescent laminar regions of the flow. Moreover, Lagrangian holes occur over few Kolmogorov time scales while Lagrangian bursts happen over longer periods scaling with the global decorrelation time scale, hence showing that loss of the history of the turbulence quantities along particle trajectories in turbulence is not continuous. Such a characteristic partially explains why current Lagrangian stochastic models fail at reproducing our results. More generally, the Lagrangian dataset of residence times shown here represents another manner for qualifying the accuracy of models. We also deliver a theoretical approximation of mean residence times, which highlights the importance of the correlation between turbulence quantities and their time derivatives in setting temporal statistics. Finally, whether in a hole or a burst, the straining structure along particle trajectories always evolves self-similarly (in a statistical sense) from shearless two-dimensional to shear bi-axial configurations. We speculate that this latter configuration represents the optimum manner to dissipate locally the available energy.
Finite-size particles modulate wall-bounded turbulence, leading, for the case of spherical particles, to increased drag also owing to the formation of a particle wall layer. Here, we study the effect of particle shape on the turbulence in suspensions of spheroidal particles at volume fraction
and show how the near-wall particle dynamics deeply changes with the particle aspect ratio and how this affects the global suspension behaviour. Direct numerical simulations are performed using a direct-forcing immersed boundary method to account for the dispersed phase, combined with a soft-sphere collision model and lubrication corrections for short-range particle–particle and particle–wall interactions. The turbulence reduces with the aspect ratio of oblate particles, leading to drag reduction with respect to the single-phase flow for particles with aspect ratio
, when the significant reduction in Reynolds shear stress is more than the compensation by the additional stresses, induced by the solid phase. Oblate particles are found to avoid the region close to the wall, travelling parallel to it with small angular velocities, while preferentially sampling high-speed fluid in the wall region. Prolate particles also tend to orient parallel to the wall and avoid its vicinity. Their reluctance to rotate around the spanwise axis reduces the wall-normal velocity fluctuation of the flow and therefore the turbulence Reynolds stress, similar to oblates; however, they undergo rotations in wall-parallel planes which increase the additional solid stresses due to their relatively larger angular velocities compared to the oblates. These larger additional stresses compensate for the reduction in turbulence activity and lead to a wall drag similar to that of single-phase flows. Spheres on the other hand, form a layer close to the wall with large angular velocities in the spanwise direction, which increases the turbulence activity in addition to exerting the largest solid stresses on the suspension, in comparison to the other studied shapes. Spherical particles therefore increase the wall drag with respect to the single-phase flow.
We study heat transfer in plane Couette flow laden with rigid spherical particles by means of direct numerical simulations. In the simulations we use a direct-forcing immersed boundary method to account for the dispersed phase together with a volume-of-fluid approach to solve the temperature field inside and outside the particles. We focus on the variation of the heat transfer with the particle Reynolds number, total volume fraction (number of particles) and the ratio between the particle and fluid thermal diffusivity, quantified in terms of an effective suspension diffusivity. We show that, when inertia at the particle scale is negligible, the heat transfer increases with respect to the unladen case following an empirical correlation recently proposed in the literature. In addition, an average composite diffusivity can be used to approximate the effective diffusivity of the suspension in the inertialess regime when varying the molecular diffusion in the two phases. At finite particle inertia, however, the heat transfer increase is significantly larger, smoothly saturating at higher volume fractions. By phase-ensemble-averaging we identify the different mechanisms contributing to the total heat transfer and show that the increase of the effective conductivity observed at finite inertia is due to the increase of the transport associated with fluid and particle velocity. We also show that the contribution of the heat conduction in the solid phase to the total wall-normal heat flux reduces when increasing the particle Reynolds number, so that particles of low thermal diffusivity weakly alter the total heat flux in the suspension at finite particle Reynolds numbers. On the other hand, a higher particle thermal diffusivity significantly increases the total heat transfer.
Phytoplankton are the foundation of aquatic food webs. Through photosynthesis, phytoplankton draw down
at magnitudes equivalent to forests and other terrestrial plants and convert it to organic material that is then consumed by other planktonic organisms in higher trophic levels. Mechanisms that affect local concentrations and velocities are of primary significance to many encounter-based processes in the plankton, including prey–predator interactions, fertilization and aggregate formation. We report results from simulations of sinking phytoplankton, considered as elongated spheroids, in homogenous isotropic turbulence to answer the question of whether trajectories and velocities of sinking phytoplankton are altered by turbulence. We show in particular that settling spheroids with physical characteristics similar to those of diatoms weakly cluster and preferentially sample regions of downwelling flow, corresponding to an increase of the mean settling speed with respect to the mean settling speed in quiescent fluid. We explain how different parameters can affect the settling speed and what underlying mechanisms might be involved. Interestingly, we observe that the increase in the aspect ratio of the prolate spheroids can affect the clustering and the average settling speed of particles by two mechanisms: first is the effect of aspect ratio on the rotation rate of the particles, which saturates faster than the second mechanism of increasing drag anisotropy.
Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990–1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.
On an 11 m firn/ice core from Kongsvegen, Svalbard, we have used dielectric profiling (DEP) to measure electrical properties, and digital photography to measure a core optical stratigraphy (COS) profile. We also used a neutron-scattering probe (NP) to measure a density profile in the borehole from which the core was extracted. The NP- and DEP-derived density profiles were similar, showing large-scale (>30 cm) variation in the gravimetric densities of each core section. Fine-scale features (<10 cm) are well characterized by the COS record and are seen at a slightly lower resolution in both the DEP and NP records, which show increasing smoothing. A combination of the density accuracy of NP and the spatial resolution of COS provides a useful method of evaluating the shallow-density profile of a glacier, improving paleoclimate interpretation, mass-balance measurement and interpretation of radar returns.
Winter balance is an important metric for assessing the change on glaciers and ice caps, yet measuring it using ground-based techniques can be challenging. We use the European Space Agency prototype Airborne SAR/Interferometric Radar Altimeter System (ASIRAS) to extract snow depths from the received altimeter waveforms over Austfonna ice cap, Svalbard. Additionally, we attempt to distinguish the long-term firn area from other glacier facies. We validate our results using snow depth and glacier facies characterizations determined from ground-based radar profiles, snow pits and a multi-look satellite synthetic aperture radar image. We show that the depth of the winter snowpack can be extracted from the altimeter data over most of the accumulation zone, comprising wet snow zone and a superimposed ice zone. The method struggles at lower elevations where internal reflections within the winter snowpack are strong and the winter snow depth is less than ∼1 m. We use the abruptness of the reflection from the last summer surface (LSS) to attempt to distinguish glacier facies. While there is a general correlation between LSS abruptness and glacier facies, we do not find a relationship that warrants a distinct classification based on ASIRAS waveforms alone.
We study suspensions of oblate rigid particles in a viscous fluid for different values of the particle volume fractions. Direct numerical simulations have been performed using a direct-forcing immersed boundary method to account for the dispersed phase, combined with a soft-sphere collision model and lubrication corrections for short-range particle–particle and particle–wall interactions. With respect to the single-phase flow, we show that in flows laden with oblate spheroids the drag is reduced and the turbulent fluctuations attenuated. In particular, the turbulence activity decreases to lower values than those obtained by accounting only for the effective suspension viscosity. To explain the observed drag reduction, we consider the particle dynamics and the interactions of the particles with the turbulent velocity field and show that the particle–wall layer, previously observed and found to be responsible for the increased dissipation in suspensions of spheres, disappears in the case of oblate particles. These rotate significantly slower than spheres near the wall and tend to stay with their major axes parallel to the wall, which leads to a decrease of the Reynolds stresses and turbulence production and so to the overall drag reduction.
Childhood trauma increases risk of a range of mental disorders including psychosis. Whereas the mechanisms are unclear, previous evidence has implicated atypical processing of emotions among the core cognitive models, in particular suggesting altered attentional allocation towards negative stimuli and increased negativity bias. Here, we tested the association between childhood trauma and brain activation during emotional face processing in patients diagnosed with psychosis continuum disorders. In particular, we tested if childhood trauma was associated with the differentiation in brain responses between negative and positive face stimuli. We also tested if trauma was associated with emotional ratings of negative and positive faces.
We included 101 patients with a Diagnostic and Statistical Manual of Mental Disorders (DSM) schizophrenia spectrum or bipolar spectrum diagnosis. History of childhood trauma was obtained using the Childhood Trauma Questionnaire. Brain activation was measured with functional magnetic resonance imaging during presentation of faces with negative or positive emotional expressions. After the scanner session, patients performed emotional ratings of the same faces.
Higher levels of total childhood trauma were associated with stronger differentiation in brain responses to negative compared with positive faces in clusters comprising the right angular gyrus, supramarginal gyrus, middle temporal gyrus and the lateral occipital cortex (Cohen's d = 0.72–0.77). In patients with schizophrenia, childhood trauma was associated with reporting negative faces as more negative, and positive faces as less positive (Cohen's d > 0.8).
Along with the observed negativity bias in the assessment of emotional valence of faces, our data suggest stronger differentiation in brain responses between negative and positive faces with higher levels of trauma.
We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.
Direct numerical simulations of the fully developed turbulent flow through a porous square duct are performed to study the effect of the permeable wall on the secondary cross-stream flow. The volume-averaged Navier–Stokes equations are used to describe the flow in the porous phase, a packed bed with porosity
. The porous square duct is computed at
and compared with the numerical simulations of a turbulent duct with four solid walls. The two boundary layers on the top wall and porous interface merge close to the centre of the duct, as opposed to the channel, because the sidewall boundary layers inhibit the growth of the shear layer over the porous interface. The most relevant feature in the porous duct is the enhanced magnitude of the secondary flow, which exceeds that of a regular duct by a factor of four. This is related to the increased vertical velocity, and the different interaction between the ejections from the sidewalls and the porous medium. We also report a significant decrease in the streamwise turbulence intensity over the porous wall of the duct (which is also observed in a porous channel), and the appearance of short spanwise rollers in the buffer layer, replacing the streaky structures of wall-bounded turbulence. These spanwise rollers most probably result from a Kelvin–Helmholtz type of instability, and their width is limited by the presence of the sidewalls.
A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
Antarctic and Southern Ocean science is vital to understanding natural variability, the processes that govern global change and the role of humans in the Earth and climate system. The potential for new knowledge to be gained from future Antarctic science is substantial. Therefore, the international Antarctic community came together to ‘scan the horizon’ to identify the highest priority scientific questions that researchers should aspire to answer in the next two decades and beyond. Wide consultation was a fundamental principle for the development of a collective, international view of the most important future directions in Antarctic science. From the many possibilities, the horizon scan identified 80 key scientific questions through structured debate, discussion, revision and voting. Questions were clustered into seven topics: i) Antarctic atmosphere and global connections, ii) Southern Ocean and sea ice in a warming world, iii) ice sheet and sea level, iv) the dynamic Earth, v) life on the precipice, vi) near-Earth space and beyond, and vii) human presence in Antarctica. Answering the questions identified by the horizon scan will require innovative experimental designs, novel applications of technology, invention of next-generation field and laboratory approaches, and expanded observing systems and networks. Unbiased, non-contaminating procedures will be required to retrieve the requisite air, biota, sediment, rock, ice and water samples. Sustained year-round access to Antarctica and the Southern Ocean will be essential to increase winter-time measurements. Improved models are needed that represent Antarctica and the Southern Ocean in the Earth System, and provide predictions at spatial and temporal resolutions useful for decision making. A co-ordinated portfolio of cross-disciplinary science, based on new models of international collaboration, will be essential as no scientist, programme or nation can realize these aspirations alone.
Various candidate waste matrices such as nuclear waste glasses, ceramic waste forms and low-specification “storage” MOX have been considered within the current UK geological disposal program for the immobilization of separated civilian plutonium, in the case this material is declared as waste. A review and evaluation of the long-term performance of potential plutonium waste forms in a deep geological repository showed that (i) the current knowledge base on the behavior and durability of plutonium waste forms under post-closure conditions is relatively limited compared to HLW-glasses from reprocessing and spent nuclear fuels, and (ii) the relevant processes and factors that govern plutonium waste form corrosion, radionuclide release and total systems behavior in the repository environment are not yet fully understood in detail on a molecular level. Bounding values for the corrosion rates of potential plutonium waste forms under repository conditions were derived from available experimental data and analogue evidence, taking into account that the current UK disposal program is in a generic stage, i.e. no preferred host rock type or disposal concept has yet been selected. The derived expected corrosion rates for potential plutonium waste forms under conditions relevant for a UK geological disposal facility are in the range of 10-4 to 10-2 g m-2 d-1 and 10-5 to 10-4 g m-2 d-1 for borosilicate glasses, and generic ceramic waste forms, respectively, and ∼5·10-6 g m-2 d-1 for storage MOX. More realistic assessments of the long-term behavior of the waste forms under post-closure conditions would require additional systematic studies regarding the corrosion and leaching behavior under more realistic post-closure conditions, to explore the safety margins of the various potential waste forms and to build confidence in long-term safety assessments for geological disposal.