In this study, we introduce ‘molecularly imprinted polymer' (MIP) system, which has receptor or binding sites with specific molecular recognitions.
Due to the receptor or binding sites in MIP's systems, it can be used for developing bio- or chemical sensors.
To fabricate bio-sensors, bio-molecules have been incorporated into MIP's systems as template molecules, but some bio-molecules are sensitive thus denatured during engineering processes.
For this reason, bio-sensor fabrications by conventional UV photolithography have shown some limitations.
We demonstrate here a photopatterning process, a micromolding in capillary technique (MIMIC) technique, to photopatterning a MIP's system containing a bio-molecule template.
The MIMIC technique uses the photo-masks for photopolymerizing MIP's monomer solutions.
The photomask is based on silicon rubbers, which are optically transparent and also minimize any damages of sensitive bio-molecules during photo-polymerizations. For visualizing lithographic performances of MIP's systems, we used a fluorescent template molecule to present a comparative result of MIP's photo-cured patterns.
It shows a clear different in MIP's patterns with and without the template.
We also employed a microfluidic approach to produce micro-sized MIP's particles, which contribute to increase the sensitivity of bio-molecule sensors/devices.