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The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort study of the Canadian Consortium on Neurodegeneration in Aging (CCNA) is a national initiative to catalyze research on dementia, set up to support the research agendas of CCNA teams. This cross-country longitudinal cohort of 2310 deeply phenotyped subjects with various forms of dementia and mild memory loss or concerns, along with cognitively intact elderly subjects, will test hypotheses generated by these teams.
The COMPASS-ND protocol, initial grant proposal for funding, fifth semi-annual CCNA Progress Report submitted to the Canadian Institutes of Health Research December 2017, and other documents supplemented by modifications made and lessons learned after implementation were used by the authors to create the description of the study provided here.
The CCNA COMPASS-ND cohort includes participants from across Canada with various cognitive conditions associated with or at risk of neurodegenerative diseases. They will undergo a wide range of experimental, clinical, imaging, and genetic investigation to specifically address the causes, diagnosis, treatment, and prevention of these conditions in the aging population. Data derived from clinical and cognitive assessments, biospecimens, brain imaging, genetics, and brain donations will be used to test hypotheses generated by CCNA research teams and other Canadian researchers. The study is the most comprehensive and ambitious Canadian study of dementia. Initial data posting occurred in 2018, with the full cohort to be accrued by 2020.
Availability of data from the COMPASS-ND study will provide a major stimulus for dementia research in Canada in the coming years.
Galactic post-AGB stars show a large diversity in chemical compositions as well as in the kinematical and geometrical properties of their circumstellar material. The theoretical interpretation is hampered by the lack of good distances to almost all Galactic objects. We therefore initiated a large project to study systematically post-AGB stars in the Large and Small Magellanic Cloud (LMC, SMC respectively). Here we report on our preliminary results.
The rational design of crystal structures, in particular noncentrosymmetric materials, and how to differentiate polar, polar-chiral, and chiral structures, is an ongoing theme in crystal engineering. In KNaNbOF5, the combination of a second-order Jahn Teller active d0 transition metal oxyfluoride anionic unit and mixed K/Na cation coordination environments are shown to result in a polar structure (space group Pna21). The crystal structure analysis of the Na/K-O/F interactions reveals that the potassium cations form one of the two contacts to the under-bonded oxide ions. These interactions satisfy the expected bond valence sums and Pauling's second crystal rule (PSCR), leading to O/F ordering and acentric packing of the [NbOF5]2− anionic unit.
In a completely between subjects design 80 male and 80 female undergraduates evaluated targets which were male or female and 25, 45, 65, or 85 years old, on the Aging Semantic Differential (ASD; Rosencranz & McNevin, 1969). Findings indicated that older targets were rated less positively than younger targets on two of the three ASD dimensions and that Target Age × Target Sex × Subject Age interactions were significant for two of the dimensions. These results replicate the target age (between subjects) effects reported by O'Connell and Rotter (1979) but not those which involved target sex (within subjects) and subject sex. It was concluded that a) subject sex and target sex affect perceptions of targets of different ages elicited from young subjects and b) between subjects versus within subjects designs produce different characterizations of such targets.
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