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Leveraging the National COVID-19 Cohort Collaborative (N3C), a nationally sampled electronic health records repository, we explored associations between individual-level social determinants of health (SDoH) and COVID-19-related hospitalizations among racialized minority people with human immunodeficiency virus (HIV) (PWH), who have been historically adversely affected by SDoH.
Methods:
We retrospectively studied PWH and people without HIV (PWoH) using N3C data from January 2020 to November 2023. We evaluated SDoH variables across three domains in the Healthy People 2030 framework: (1) healthcare access, (2) economic stability, and (3) social cohesion with our primary outcome, COVID-19-related hospitalization. We conducted hierarchically nested additive and adjusted mixed-effects logistic regression models, stratifying by HIV status and race/ethnicity groups, accounting for age, sex, comorbidities, and data partners.
Results:
Our analytic sample included 280,441 individuals from 24 data partner sites, where 3,291 (1.17%) were PWH, with racialized minority PWH having higher proportions of adverse SDoH exposures than racialized minority PWoH. COVID-19-related hospitalizations occurred in 11.23% of all individuals (9.17% among PWH, 11.26% among PWoH). In our initial additive modeling, we observed that all three SDoH domains were significantly associated with hospitalizations, even with progressive adjustments (adjusted odds ratios [aOR] range 1.36–1.97). Subsequently, our HIV-stratified analyses indicated economic instability was associated with hospitalization in both PWH and PWoH (aOR range 1.35–1.48). Lastly, our fully adjusted, race/ethnicity-stratified analysis, indicated access to healthcare issues was associated with hospitalization across various racialized groups (aOR range 1.36–2.00).
Conclusion:
Our study underscores the importance of assessing individual-level SDoH variables to unravel the complex interplay of these factors for racialized minority groups.
Some studies found that providing micronutrient powder (MNP) causes adverse health outcomes, but modifying factors are unknown. We aimed to investigate whether Fe status and inherited Hb disorders (IHbD) modify the impact of MNP on growth and diarrhoea among young Lao children. In a double-blind controlled trial, 1704 children of age 6–23 months were randomised to daily MNP (with 6 mg Fe plus fourteen micronutrients) or placebo for about 36 weeks. IHbD, and baseline and final Hb, Fe status and anthropometrics were assessed. Caregivers provided weekly morbidity reports. At enrolment, 55·6 % were anaemic; only 39·3 % had no sign of clinically significant IHbD. MNP had no overall impact on growth and longitudinal diarrhoea prevalence. Baseline Hb modified the effect of MNP on length-for-age (LAZ) (P for interaction = 0·082). Among children who were initially non-anaemic, the final mean LAZ in the MNP group was slightly lower (–1·93 (95 % CI –1·88, –1·97)) v. placebo (–1·88 (95 % CI –1·83, –1·92)), and the opposite occurred among initially anaemic children (final mean LAZ –1·90 (95 % CI –1·86, –1·94) in MNP v. –1·92 (95 % CI –1·88, –1·96) in placebo). IHbD modified the effect on diarrhoea prevalence (P = 0·095). Among children with IHbD, the MNP group had higher diarrhoea prevalence (1·37 (95 % CI 1·17, 1·59) v. 1·21 (95 % CI 1·04, 1·41)), while it was lower among children without IHbD who received MNP (1·15 (95 % CI 0·95, 1·39) v. 1·37 (95 % CI 1·13, 1·64)). In conclusion, there was a small adverse effect of MNP on growth among non-anaemic children and on diarrhoea prevalence among children with IHbD.
Thirty data sets of wavestaff measurements of a solitary feature in the Kelvin wake of the Coast Guard cutter Point Brower are analysed. The average characteristics of the feature between 1 and 4 km aft of the ship are shown to be consistent with those of an oblique nonlinear solitary wave packet. The ship speed is 7.7 m/s (Froude number 0.49) and the waves that comprise the packet have an average frequency of 3.28 rad/s. The ship speed and the wave frequency, together with Kelvin wake kinematics, imply that the feature appears at an average wake half-angle of 10.9°. The packet does not exhibit linear dispersion beyond 1 km aft of the ship and its average width is 8.9 m (measured at e−1 of the peak variance). The average amplitude is 1.1 times the theoretical amplitude of an oblique nonlinear solitary wave packet with the observed width. There is considerable variability from run to run, and there is evidence of dispersive spreading before 1 km aft of the ship. An aerial photograph shows a sinuous fluctuation of the feature; possible explanations for the fluctuation include small variations in initial conditions or a sinuous instability. The solitary feature is a possible explanation for the long bright lines observed in SEASAT SAR images in light to moderate winds and observed in sun glitter photos taken from the space shuttle.
Objective: Research indicates that children benefit from
supportive interventions to help them cope with the loss of a loved one.
The aim of this pilot study was to evaluate children's perceptions of
the effectiveness of a grief camp.
Methods: Semistructured interviews were performed with 18
children who attended a weekend-long grief camp. Children also responded
to follow-up interviews via telephone. Their parents also completed
surveys before camp began and either after camp ended or at a follow-up
evaluation. Data were analyzed using descriptive statistics and content
coding to uncover key themes in the interviews.
Results: Children reported that art activities helped them to
express feelings about their grief and release feelings of sadness and
worry related to the death. Parents and children felt that the camp was a
positive experience and that the children benefited from being in groups
with peers who had also lost family members.
Significance of results: Evaluating the impact of grief
camps, using practical methods such as the ones for this study, is
important, as these camps are becoming more popular interventions.
Children and parents may benefit from contact at specified follow-up
periods after camp to determine if they would benefit from further
therapy. Results also provide evidence of the success of this program,
which supports the need for funding these types of interventions.