To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Congenital lung malformations are a heterogeneous group of abnormalities resulting from defective foregut specification, branching morphogenesis and cell proliferation, survival, and differentiation. Advancements in radiologic imaging and routine investigations in utero have resulted in a shift from postnatal to prenatal diagnoses. Prenatal diagnosis provides an opportunity to follow congenital malformations sequentially to better understand pathophysiological mechanisms. Genetic analysis of patients with hereditary lung malformations has also shed light on the molecular mechanisms underlying aberrant lung organogenesis. In this chapter, an overview of the five stages of lung development is given followed by discussion of the congenital lung malformations that result from defects in early and late lung morphogenesis. The malformations are described followed by a discussion of the associated syndromes, etiology, and pathogenesis with a focus toward the underlying cellular and molecular mechanisms. Clinical presentations, diagnosis, treatments, and outcomes are summarized, including radiographic and pathologic images of the most common malformations. The anomalies are presented in a format designed to provide clinicians caring for fetal and neonatal patients as well as scientists interested in lung development with a concise, up-to-date overview of congenital lung malformations and the deregulated cellular and molecular processes underlying their pathogenesis.
Email your librarian or administrator to recommend adding this to your organisation's collection.