We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
In patients with schizophrenia in a psychotic episode, intra-striatal intrinsic connectivity is increased in the putamen but not ventral striatum. Furthermore, multimodal changes have been observed in the anterior insula that interact extensively with the putamen.
Aims
We hypothesised that during psychosis, putamen extra-striatal functional connectivity is altered with both the anterior insula and areas normally connected with the ventral striatum (i.e. altered functional connectivity distinctiveness of putamen and ventral striatum).
Method
We acquired resting-state functional magnetic resonance images from 21 patients with schizophrenia in a psychotic episode and 42 controls.
Results
Patients had decreased functional connectivity: the putamen with right anterior insula and dorsal prefrontal cortex, the ventral striatum with left anterior insula. Decreased functional connectivity between putamen and right anterior insula was specifically associated with patients' hallucinations. Functional connectivity distinctiveness was impaired only for the putamen.
Conclusions
Results indicate aberrant extra-striatal connectivity during psychosis and a relationship between reduced putamen–right anterior insula connectivity and hallucinations. Data suggest that altered intrinsic connectivity links striatal and insular pathophysiology in psychosis.
Alterations in the dopaminergic reward system, predominantly the
striatum, constitute core characteristics of schizophrenia.
Aims
Functional connectivity of the dorsal striatum during reward-related
trial-and-error learning was investigated in 17 people with schizophrenia
and 18 healthy volunteers and related to striatal grey matter volume and
psychopathology.
Method
We used voxel-based morphometry and psychophysiological interaction to
examine striatal volume and connectivity.
Results
A reduced functional connectivity between left striatum and
temporo-occipital areas, precuneus and insula could be detected in the
schizophrenia group. The positive correlation between grey matter volume
and functional connectivity of the left striatum yielded significant
results in a very similar network. Connectivity of the left striatum was
negatively correlated with negative symptoms.
Conclusions
Present results suggest a disruption in striatal functional connectivity
that is closely linked to grey matter morphometry of the striatum.
Decreased connectivity between the striatum and psychopathologically
relevant networks may explain the emergence of negative symptoms.
Schizophrenia is associated with often widespread changes in white matter
structure. Most studies have investigated changes in fractional
anisotropy, whereas alterations in radial or axial diffusivity have
barely been investigated until now.
Aims
To investigate radial diffusivity as a potential marker of dysmyelination
in direct relation to abnormalities in neural activation.
Method
Neural activation in association with decision-making under uncertainty
was investigated in 19 people with schizophrenia and 20 healthy controls
and linked to radial diffusivity as measured by diffusion tensor
imaging.
Results
Decision-making under uncertainty was associated with a significantly
decreased activation in a frontostriatocingulate network in the
schizophrenia group. Structurally, they exhibited increased radial
diffusivity in temporal white matter that was negatively correlated with
activation in parts of the frontostriatocingulate network.
Conclusions
Present data indicate that altered diffusivity within relevant white
matter networks may be closely linked to abnormal neural activation in
schizophrenia.
Recommend this
Email your librarian or administrator to recommend adding this to your organisation's collection.