Technology-enabled approaches to conducting 24-h dietary recalls (24HR) may reduce dietary assessment bottlenecks in low-resource settings. However, few studies have assessed their performance relative to conventional pen-and-paper interview (PAPI) approaches and none have validated performance against a benchmark (e.g. weighed food record (WFR)) in a low- and middle-income country (LMIC). This study assessed relative accuracy and cost-effectiveness of INDDEX24, a technology-enabled approach to conducting 24HR, compared with a PAPI approach and against an observer WFR. Women aged 18–49 years from northern Viet Nam (n 234) were randomly assigned to be interviewed using INDDEX24 or PAPI 24HR following a WFR. The two one-sided t test approach assessed the equivalence of each recall modality to the benchmark. Difference-in-differences analysis compared the recall-benchmark results across modalities. Cost per percentage point of accuracy for INDDEX24 and PAPI was derived from accuracy results and the cost to conduct the 24HR. The PAPI and INDDEX24 24HR were statistically equivalent to the WFR for all nutrients except vitamin A. INDDEX24 diverged significantly less than PAPI from the WFR for Fe (0·9 v. −1·3 mg) and PAPI diverged less for protein (–3·7 v. 7·9 g). At the individual level, 26 % of PAPI and 32 % of INDDEX24 respondents had energy intakes within +/– 10 % of the WFR. INDDEX24 cost $111 004 and the PAPI cost $120 483 (USD 2019), making INDDEX24 more cost-effective across most indicators. INDDEX24 was an accurate and cost-effective method for assessing dietary intake in the study context and represents a preferred alternative to PAPI 24HR in Viet Nam and other LMIC.

The segregation of reactive elements (REs) along thermally grown oxide (TGO) grain boundaries has been associated to slower oxide growth kinetics and improved creep properties. However, the incorporation and diffusion of these elements into the TGO during oxidation of Ni alloys remains an open question. In this work, electron backscatter diffraction in transmission mode (t-EBSD) was used to investigate the microstructure of TGO within the thermal barrier coating on a Ni-based superalloy, and atom probe tomography (APT) was used to quantify the segregation behavior of REs to α-Al2O3 grain boundaries. Integrating the two techniques enables a higher level of site-specific analysis compared to the routine focused ion beam lift-out sample preparation method without t-EBSD. Needle-shaped APT specimens readily meet the thickness criterion for electron diffraction analysis. Transmission EBSD provides an immediate feedback on grain orientation and grain boundary location within the APT specimens to help target grain boundaries in the TGO. Segregation behavior of REs is discussed in terms of the grain boundary character and relative location in TGO.

The INDDEX24 Dietary Assessment Platform (INDDEX24) was developed to facilitate the collection of 24-h dietary recall (24HR) data. Alongside validation studies in Viet Nam and Burkina Faso in 2019–2020, we conducted activity-based costing studies to estimate the cost of conducting a 24HR among women of reproductive age using INDDEX24 compared with the pen-and-paper interview (PAPI) approach. We also modelled alternative scenarios in which: (1) 25–75 % of dietary reference data were borrowed from the INDDEX24 Global Food Matters Database (FMDB); (2) all study personnel were locally based and (3) national-scale surveys. In the primary analysis, in Viet Nam, the 24HR cost US $111 004 ($755/respondent, n 147) using INDDEX24 and $120 483 ($820/respondent, n 147) using PAPI. In Burkina Faso, the 24HR cost $78 105 ($539/respondent, n 145) using INDDEX24 and $79 465 ($544/respondent, n 146) using PAPI. In modelled scenarios, borrowing dietary reference data from the FMDB decreased the cost of INDDEX24 by 17–34 % (Viet Nam) and 5–15 % (Burkina Faso). With all locally based personnel, INDDEX24 cost more than PAPI ($498 v. $448 per respondent in Viet Nam and $456 v. $410 in Burkina Faso). However, at national scales (n 4376, Viet Nam; n 6500, Burkina Faso) using all locally based personnel, INDDEX24 was more cost-efficient ($109 v. $137 per respondent in Viet Nam and $123 v. $148 in Burkina Faso). In two countries and under most circumstances, INDDEX24 was less expensive than PAPI. Higher INDDEX24 survey preparation costs (including purchasing equipment) were more than offset by higher PAPI data entry, cleaning and processing costs. INDDEX24 may facilitate cost-efficient dietary data collection.

The National Institute of Mental Health's Research Domain Criteria (RDoC) framework has prompted a paradigm shift from categorical psychiatric disorders to considering multiple levels of vulnerability for probabilistic risk of disorder. However, the lack of neurodevelopmentally based tools for clinical decision making has limited the real-world impact of the RDoC. Integration with developmental psychopathology principles and statistical methods actualize the clinical implementation of RDoC to inform neurodevelopmental risk. In this conceptual paper, we introduce the probabilistic mental health risk calculator as an innovation for such translation and lay out a research agenda for generating an RDoC- and developmentally informed paradigm that could be applied to predict a range of developmental psychopathologies from early childhood to young adulthood. We discuss methods that weigh the incremental utility for prediction based on intensity and burden of assessment, the addition of developmental change patterns, considerations for assessing outcomes, and integrative data approaches. Throughout, we illustrate the risk calculator approach with different neurodevelopmental pathways and phenotypes. Finally, we discuss real-world implementation of these methods for improving early identification and prevention of developmental psychopathology. We propose that mental health risk calculators can build a needed bridge between the RDoC multiple units of analysis and developmental science.

Effective nutrition policies require timely, accurate individual dietary consumption data; collection of such information has been hampered by cost and complexity of dietary surveys and lag in producing results. The objective of this work was to assess accuracy and cost-effectiveness of a streamlined, tablet-based dietary data collection platform for 24-hour individual dietary recalls (24HR) administered using INDDEX24 platform v. a pen-and-paper interview(PAPI) questionnaire, with weighed food record (WFR) as a benchmark. This cross-sectional comparative study included women 18–49 years old from rural Burkina Faso (n 116 INDDEX24; n 115 PAPI). A WFR was conducted; the following day, a 24HR was administered by different interviewers. Food consumption data were converted into nutrient intakes. Validity of 24HR estimates of nutrient and food group consumption was based on comparison with WFR using equivalence tests (group level) and percentages of participants within ranges of percentage error (individual level). Both modalities performed comparably estimating consumption of macro- and micronutrients, food groups and quantities (modalities’ divergence from WFR not significantly different). Accuracy of both modalities was acceptable (equivalence to WFR significant at P < 0·05) at group level for macronutrients, less so for micronutrients and individual-level consumption (percentage within ±20 % for WFR, 17–45 % for macronutrients, 5–17 % for micronutrients). INDDEX24 was more cost-effective than PAPI based on superior accuracy of a composite nutrient intake measure (but not gram amount or item count) due to lower time and personnel costs. INDDEX24 for 24HR dietary surveys linked to dietary reference data shows comparable accuracy to PAPI at lower cost.

This work investigated the effects of repeated sweet taste exposure at breakfast on perceptions and intakes of other sweet foods, while also examining the effects due to duration of exposure (1/3 weeks), test context (breakfast/lunch) and associations between taste perceptions and intakes. Using a randomised controlled parallel-group design, participants (n 54, 18 male, mean age: 23·9 (sd 5·8) years, mean BMI: 23·6 (sd 3·5) kg/m2) were randomised to consume either a sweet breakfast (cereal with sucralose) (n 27) or an equienergetic non-sweet breakfast (plain cereal) (n 27) for 3 weeks. On days 0 (baseline), 7 and 21, pleasantness, desire to eat and sweetness were rated for other sweet and non-sweet foods and sweet food consumption was assessed in an ad libitum meal at breakfast and lunch. Using intention-to-treat analyses, no statistically significant effects of exposure were found at breakfast (largest F2,104 = 1·84, P = 0·17, ηp2 = 0·03) or lunch (largest F1,52 = 1·22, P = 0·27, ηp2 = 0·02), and using Bayesian analyses, the evidence for an absence of effect in all rating measures was strong to very strong (smallest BF01 = 297·97 (BF01error = 2·68 %)). Associations between ratings of pleasantness, desire to eat and intake were found (smallest r = 0·137, P < 0·01). Effects over time regardless of exposure were also found: sugars and percentage energy consumed from sweet foods increased throughout the study (smallest (F2,104 = 4·54, P = 0·01, ηp2 = 0·08). These findings demonstrate no effects of sweet taste exposure at breakfast for 1 or 3 weeks on pleasantness, desire for, sweetness or intakes of other sweet foods in either the same (breakfast) or in a different (lunch) meal context.

During the past two decades, it has been amply documented that neuropsychiatric disorders (NPDs) disproportionately account for burden of illness attributable to chronic non-communicable medical disorders globally. It is also likely that human capital costs attributable to NPDs will disproportionately increase as a consequence of population aging and beneficial risk factor modification of other common and chronic medical disorders (e.g., cardiovascular disease). Notwithstanding the availability of multiple modalities of antidepressant treatment, relatively few studies in psychiatry have primarily sought to determine whether improving cognitive function in MDD improves patient reported outcomes (PROs) and/or is cost effective. The mediational relevance of cognition in MDD potentially extrapolates to all NPDs, indicating that screening for, measuring, preventing, and treating cognitive deficits in psychiatry is not only a primary therapeutic target, but also should be conceptualized as a transdiagnostic domain to be considered regardless of patient age and/or differential diagnosis.

Field research was conducted in 2012 and 2013 in Georgia, New York, and North Carolina to evaluate the effect of trifluralin PPI on turnip root production. Treatments included trifluralin PPI at 0, 0.42, 0.56, 0.84, 1.12, 1.68, 2.24, and 3.36 kg ai ha−1. Aboveground injury to turnip varied by location and increased from 0% to 85% as trifluralin rate increased from 0.42 to 3.36 kg ha−1. Trifluralin at 0.42 to 0.84 kg ha−1 caused ≤7% injury, except at Clayton, NC, and Freeville, NY, where injury ≤32%. Trifluralin at 0.42 to 0.84 kg ha−1 reduced turnip root yield ≤11% at all locations, except Clinton, NC, where yield was reduced 29% and 43% by 0.56 and 0.84 kg ha−1, respectively. Turnip roots were not injured internally by trifluralin. Our research results suggest that up to 0.84 kg ha−1 trifluralin PPI is safe to use in turnip roots.

Herbicide systems consisting of PRE, early POST, and late POST options arranged factorially were compared for control of sicklepod in narrow-row soybean with modified acetolactate synthase (ALS) (E.C.4.1.3.18). Other weeds present included common cocklebur and mixed infestations of entireleaf, ivyleaf, pitted, and tall morningglories. PRE options were alachlor or alachlor plus metribuzin plus chlorimuron. Early POST options included chlorimuron, chlorimuron plus thifensulfuron, and no herbicide applied 3 wk after planting. Late POST options were chlorimuron and no herbicide applied 5 wk after planting. POST herbicides were more effective than PRE herbicides on all weeds. Chlorimuron and chlorimuron plus thifensulfuron applied early POST were equally effective on these weeds and usually more effective than chlorimuron applied late POST. There was no advantage of two POST applications compared with a single early POST application. Greatest net returns were obtained in systems using only early POST herbicides. There was no economic advantage from using metribuzin plus chlorimuron PRE in systems that included an early POST herbicide.

Systems consisting of flumetsulam, metribuzin plus chlorimuron, or imazaquin applied PPI with trifluralin or PRE with metolachlor were compared with and without chlorimuron POST for control of sicklepod and entireleaf morningglory in narrow-row soybean at four locations. Control of sicklepod and entireleaf morningglory by soil-applied herbicides was generally inadequate. Control of sicklepod by flumetsulam exceeded control by metribuzin plus chlorimuron or imazaquin at one location. Entireleaf morningglory control by flumetsulam was similar to or less than control by metribuzin plus chlorimuron or imazaquin. Chlorimuron POST was a more important component of management systems for these weeds than was flumetsulam, metribuzin plus chlorimuron, or imazaquin PPI or PRE. Pooled over soil-applied herbicides, chlorimuron POST increased late-season control of sicklepod and entireleaf morningglory 25 to 61% and 22 to 54%, respectively; increased soybean yield 20 to 55%; decreased foreign matter contamination 5 to 13%; and increased net returns $34 to $185/ha. When used in conjunction with chlorimuron POST, flumetsulam, metribuzin plus chlorimuron, and imazaquin applied PPI with trifluralin or PRE with metolachlor increased late-season control of sicklepod and entireleaf morningglory only when control by trifluralin or metolachlor followed by chlorimuron POST was less than 66 and 77%, respectively.

The effect of bromoxynil on large crabgrass control by clethodim, sethoxydim, fluazifop-P, fluazifop-P plus fenoxaprop-P, and quizalofop-P was evaluated in 1996 and 1997 in bromoxynil-tolerant cotton and in fallow areas. Bromoxynil at 560 g ai/ha reduced large crabgrass control 4 weeks after treatment (WAT) when mixed with labeled rates of fluazifop-P, fluazifop-P plus fenoxaprop-P, or quizalofop-P. Control 9 WAT was reduced when bromoxynil was mixed with any of the graminicides. Antagonism with the mixtures was greatest with quizalofop-P, intermediate with fluazifop-P plus fenoxaprop-P and fluazifop-P, and least with clethodim and sethoxydim. Increasing the graminicide rate 50% in mixtures with bromoxynil alleviated antagonism only for clethodim. No antagonism was noted 9 WAT when bromoxynil was applied 3 d before or 3 d after application of clethodim or sethoxydim or when bromoxynil was applied 3 d after fluazifop-P plus fenoxaprop-P. Antagonism was observed when bromoxynil was applied 3 d before fluazifop-P plus fenoxaprop-P or when applied 3 d before or 3 d after fluazifop-P and quizalofop-P. Regardless of bromoxynil application, greatest yields were obtained from cotton treated with clethodim or sethoxydim. Bromoxynil applied 3 d before or 3 d after clethodim, sethoxydim, or fluazifop-P plus fenoxaprop-P did not reduce yield. Yield was reduced when bromoxynil was applied 3 d before or 3 d after application of fluazifop-P or quizalofop-P and when bromoxynil was mixed with any graminicide.

An experiment was conducted at six locations in North Carolina to compare weed-management treatments using glufosinate postemergence (POST) in glufosinate-resistant soybean, glyphosate POST in glyphosate-resistant soybean, and imazaquin plus SAN 582 preemergence (PRE) followed by chlorimuron POST in nontransgenic soybean. Prickly sida and sicklepod were controlled similarly and 84 to 100% by glufosinate and glyphosate. Glyphosate controlled broadleaf signalgrass, fall panicum, goosegrass, rhizomatous johnsongrass, common lambsquarters, and smooth pigweed at least 90%. Control of these weeds by glyphosate often was greater than control by glufosinate. Mixing fomesafen with glufosinate increased control of these species except johnsongrass. Glufosinate often was more effective than glyphosate on entireleaf and tall morningglories. Fomesafen mixed with glyphosate increased morningglory control but reduced smooth pigweed control. Glufosinate or glyphosate applied sequentially or early postemergence (EPOST) following imazaquin plus SAN 582 PRE often were more effective than glufosinate or glyphosate applied only EPOST. Only rhizomatous johnsongrass was controlled more effectively by glufosinate or glyphosate treatments than by imazaquin plus SAN 582 PRE followed by chlorimuron POST. Yields and net returns with soil-applied herbicides only were often lower than total POST herbicide treatments. Sequential POST herbicide applications or soil-applied herbicides followed by POST herbicides were usually more effective economically than single POST herbicide applications.