To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
This chapter discusses the pathophysiology, implications, diagnostic signs and diagnostic signs of sepsis and septic shock in pregnancy. In severe sepsis the key pathology is endothelial dysfunction (endothelial apoptosis, increased expression of adhesion molecules and increased capillary permeability) and disordered coagulation homeostasis. It is also important to note that the signs and symptoms of sepsis can be non-specific. The principles of treatment revolve around the basic elements of resuscitation (Airways, Breathing, and Circulation), treatment of the underlying infection including surgical drainage or excision, and organ support until recovery. The use of Modified Early Obstetric Warning System (MEOWS) charts has been shown to minimise risk in the unwell obstetric patient. Prophylactic antibiotic administration is recommended in a number of clinical scenarios to prevent infection in women considered to be at risk. Adjuvant interventions includes surgical removal of infections, use of low-dose steroids and administering activated protein C, an exogenous anticoagulant.