We report on the design of polycaprolactone (PCL)-TiO2-collagenase mesh scaffolds by Forcespinning technique. The dependence of the degree of crystallinity in PCL caused by the incorporation of dopants (TiO2-collagenase) and the reduction of dimensionality (1D), during the nanofiber formation, were investigated by x-ray diffraction and differential scanning calorimetry. The tensile strength of the mesh scaffolds (randomly oriented) was determined using uniaxial testing equipment. The permeability was measured by contact angle obtaining an improvement in the hydrophobicity for the PCL-TiO2-collagenase mesh scaffolds. The results reported in this research are of great relevance for tissue engineering applications.