A survey questionnaire was sent to cotton consultants of Arkansas and Mississippi through direct mail and Louisiana and Tennessee consultants through on-farm visits in fall of 2011. The survey was returned by a total of 22 Arkansas, 17 Louisiana, 10 Mississippi, and 11 Tennessee cotton consultants, representing 26, 53, 13, and 38% of total cotton planted in these states in 2011, respectively. Collectively, the area planted to glyphosate-resistant (Roundup Ready®, RR) cotton was 97%, glyphosate plus glufosinate-resistant (Widestrike® Flex, WRF) cotton was 30%, and glufosinate-resistant (Liberty Link, LL) cotton was 2.6% of the total cotton surveyed in 2011. Seventy percent of area in all states is still under continuous RR/WRF cotton. Average cost of herbicides in RR systems was $114 ha−1 and in LL systems was $137 ha−1. Across the states, cotton planted under no-tillage, conservation tillage, and conventional tillage was 31, 36, and 33%, respectively, of total scouted cotton. Area under conventional tillage increased and conservation tillage decreased in Arkansas compared with a previous survey conducted in 2006. Palmer amaranth, morningglories, and horseweed in the order of listing were the most problematic weeds of cotton across Arkansas, Mississippi, and Tennessee. In Louisiana, however, morningglories were the most problematic weed followed by Palmer amaranth and common waterhemp. Glyphosate-resistant (GR) Palmer amaranth infested only 13% of scouted cotton area in Louisiana compared with 75% in the remaining three states, and consequently, hand-weeding to control GR Palmer amaranth is practiced on only 2.5% of total scouted area of Louisiana and 49% of the scouted area of the remaining three states. Hand-weeding added an additional $12 to 371 ha−1 to weed-management costs. One-half (50%) of the cotton consultants emphasized the need for more research on residual herbicides that can control GR Palmer amaranth effectively.