To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The rapid proliferation of interest in adaptive designs, and inconsistent use of terminology, has created confusion about similarities and differences among the various techniques. This chapter focuses on some specific adaptive designs that have received the most attention to date. Although many adaptive designs employ the use of Bayesian statistical techniques, it is important to consider both Bayesian and Frequentist approaches to adaptive designs. Adaptive designs are generally well accepted and encouraged for early phases of drug development. For confirmatory trials, regulatory agencies will accept some adaptive designs but are cautious about others. A number of adaptive designs have been classified as 'generally well understood adaptive designs with valid approaches to implementation' in the FDA guidance document on adaptive designs. The major barriers to the implementation of adaptive designs in future clinical trial protocols are primarily logistical, rather than statistical.